Design and Cytotoxicity Analysis of a Conjugate Containing the New DGalactose- Binding Lectin SELld and the Non-Toxic Type 2 Ribosome- Inactivating Protein Nigrin b

Publisher： Bentham Science Publishers

E-ISSN： 1875-628x|1|4|361-367

ISSN： 1570-1808

Source： Letters in Drug Design & Discovery, Vol.1, Iss.4, 2004-10, pp. : 361-367

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Abstract

Conjugates containing nigrin b (two-chain RIP) linked to a new lectin (SELld) from Sambucus ebulus L. have been designed. They retain the anti-ribosomal inhibitory activity of nigrin b but, in contrast to nigrin b, they exerted strong cytotoxicity on COLO 320 and HeLa cells, which ran in parallel with DNA fragmentation.

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