Publisher： Bentham Science Publishers
E-ISSN： 1873-5592|9|8|674-682
ISSN： 1389-4501
Source： Current Drug Targets, Vol.9, Iss.8, 2008-08, pp. : 674-682
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Abstract
Ceramide kinase (CERK) was discovered more than a decade ago. Since then, numerous reports have been published demonstrating a role for CERK in various signal transduction pathways involved in inflammation, immunity or cancer. In this review, the biosynthesis of ceramide-1-phosphate (C1P) and the various roles of CERK and C1P in biological mechanisms will be overviewed. We will focus on the role of C1P in eicosanoid synthesis, more specifically, in the activation and translocation of cPLA2. Furthermore, the possible therapeutic relevance of inhibitors of these mechanisms is discussed.
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