Publisher： Bentham Science Publishers
E-ISSN： 1875-628x|5|1|15-24
ISSN： 1570-1808
Source： Letters in Drug Design & Discovery, Vol.5, Iss.1, 2008-01, pp. : 15-24
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Abstract
Fifteen new hydrazones were synthesized as derivatives of 1H-1-pyrrolylcarbohydrazides. Six products exhibited 73-98% inhibition against Mycobacterium tuberculosis H37Rv at 6.25 μg/mL using Microplate Alamar Blue Assay, the most active evaluated at HTS Level 2 with IC50=0.966 and IC90=3.236. The activities correlate with molecular volumes in simplified second order QSAR model.
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