Publisher： Bentham Science Publishers
E-ISSN： 1873-4251|7|2|163-168
ISSN： 1570-162X
Source： Current HIV Research, Vol.7, Iss.2, 2009-03, pp. : 163-168
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Abstract
Pre-mRNA splicing is a critical step in gene expression for metazoans. Several viral proteins regulate the splicing of pre-mRNAs through complex interactions with the host cell RNA splicing machinery. Here, we focus on a novel function of HIV-1 Vpr, which selectively inhibits cellular and viral pre-mRNA splicing via interactions with components of the spliceosome complex. This review discusses our current knowledge of how RNA splicing regulation is accomplished by Vpr-host factor interactions.
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