Structural Approach for COX-2 Inhibition

Publisher： Bentham Science Publishers

E-ISSN： 1875-5607|4|6|603-615

ISSN： 1389-5575

Source： Mini Reviews in Medicinal Chemistry, Vol.4, Iss.6, 2004-08, pp. : 603-615

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Abstract

The design of selective COX-2 inhibitors is a new approach to obtain potent, anti-inflammatory drugs but with less side effects. Several families of such inhibitors were reported in literature. In this review, the drug design processes used to understand their binding mode and the origin of selectivity of these compounds are described.

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