STUDIES OF COMMON BALDNESS IN THE STUMP‐TAILED MACAQUE

Publisher: John Wiley & Sons Inc

E-ISSN: 1346-8138|1|1|14-21

ISSN: 0385-2407

Source: THE JOURNAL OF DERMATOLOGY, Vol.1, Iss.1, 1974-03, pp. : 14-21

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Abstract

ABSTRACTSkin slices containing various types of hair follicles were obtained from both the bald and hairy regions of the scalp and from the chin and the back of adult stump‐tailed macaques and from the scalp of preadolescent and infant animals. These were incubated in TC 199 containing tritiated testosterone. Testosterone and its six metabolites were extracted and isolated by thin‐layer chromatography. The amounts extracted from anagen hair sheath, anagen hair bulb, and telogen hair sheath of both terminal and vellus hair were compared.No statistically significant differences were obtained from the comparison of the means of each sample group. But the amount of 5α‐dihydrotestosterone (5‐DHT) was comparatively higher than testosterone and androstenedione in the frontal area indifferent on age differences whereas the amount of 5‐DHT was lower in the occipital and back area.These data suggest the existence of regional differences in testosterone metabolism in the scalp skin. No clue was provided to make clear the genesis of male‐pattern baldness in the stump‐tailed macaque.