Potential Efficacy of Low Metal Diets and Dental Metal Elimination in the Management of Atopic Dermatitis: An Open Clinical Study

Publisher: John Wiley & Sons Inc

E-ISSN: 1346-8138|24|1|12-19

ISSN: 0385-2407

Source: THE JOURNAL OF DERMATOLOGY, Vol.24, Iss.1, 1997-01, pp. : 12-19

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Abstract

AbstractWe performed an open clinical study on the effects of low metal diets and/or dental metal elimination on 27 patients with moderate to severe atopic dermatitis (AD), who showed positive patch tests for metal allergens and/or clinical exacerbation by oral provocation tests with metal salts. All the patients were recommended to ingest low metal diets for 3 months and/or undergo dental metal elimination. Marked or moderate improvement was noted in 18 patients (67%); 7 patients (26%) showed marked improvement and 11 patients (41%), moderate improvement. Nine patients (33%) showed minimal improvement or no change. In the patients who showed marked or moderate improvement, we observed statistically significant decreases (p<0.05) in both peripheral blood eosinophil counts and serum LDH levels after 3 months of treatment. The present study suggests that restriction of ingested metal allergens to which patients have positive patch tests and/or oral challenge tests may be useful in the management of some patients with AD who have metal sensitivity.

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