Publisher： John Wiley & Sons Inc
E-ISSN： 1346-8138|12|2|138-142
ISSN： 0385-2407
Source： THE JOURNAL OF DERMATOLOGY, Vol.12, Iss.2, 1985-04, pp. : 138-142
Disclaimer: Any content in publications that violate the sovereignty, the constitution or regulations of the PRC is not accepted or approved by CNPIEC.
Abstract
ABSTRACTCells of B16‐conv line isolated from a cultured B16 mouse melanoma cell strain are spindle‐shaped cells (S type) with tyrosinase activity under usual culture conditions. When the cells were seeded for colony formation on plastic substratum in Eagle's MEM containing cepharanthine (0.8–1.0 µM), cell‐type conversion occurred from the spindle‐shaped to DOPA‐negative fibroblast‐like cell (F type) with a significant frequency.
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