Synthesis of 2‐[18F]Fluoro‐2‐deoxyisosorbide 5‐mononitrate and Assessment of Its in vivo Biodistribution as Determined by Dynamic Positron Emission Tomography (PET)

Publisher： John Wiley & Sons Inc

E-ISSN： 1860-7187|1860-7179|10|1724-1732

ISSN： 1860-7179

Source： CHEMMEDCHEM, Vol.1860-7179, Iss.10, 2015-10, pp. : 1724-1732

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Abstract

AbstractHerein we disclose the synthesis of 2‐fluoro‐2‐deoxyisosorbide 5‐mononitrate (2F‐IS‐5MN), a fluorinated analogue of the commonly prescribed vasodilator isosorbide 5‐mononitrate (IS‐5MN). X‐ray structural data for IS‐5MN and its C2‐epimeric congener IM‐5MN are presented together with structural data for 2F‐IS‐5MN. Radioisotope labeling of 2F‐IS‐5MN has, for the first time, allowed observation of the in vivo biodistribution of this organic nitrate by means of dynamic positron emission tomography (PET) in wild‐type mice.

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