Publisher: John Wiley & Sons Inc
E-ISSN: 1365-2672|1364-5072|4|1127-1137
ISSN: 1364-5072
Source: JOURNAL OF APPLIED MICROBIOLOGY, Vol.1364-5072, Iss.4, 2015-10, pp. : 1127-1137
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Abstract
AbstractAimsThis study was designed to demonstrate the protective effects of Bifidobacterium longum BBMN68‐specific modulated dendritic cells (DCs) on allergic inflammation in β‐lactoglobulin (BLG)‐sensitized mice.Methods and ResultsBALB/c mice were sensitized to BLG in accordance with a model of food allergy protocol and given oral BBMN68 daily. BBMN68 was found to significantly reduce BLG‐specific hypersensitivity reactions by suppressing the aberrant balance of Th1/Th2 responses with increasing the number of CD4+CD25+Foxp3+ Treg cells in mesenteric lymph nodes (MLN) by 48·1%. The level of CD103+DCs was up‐regulated by 136·7 and 56·2% in payer's patches and MLN, respectively, in response to the lower expression levels of cell‐surface molecules (CD86 and MHC‐II) induced by BBMN68 supplementation. The CD11c+DCs isolated from BBMN68 mice showed 45·6% more Foxp3+ expression in vitro.ConclusionsThese data suggest that BBMN68‐specific induction of CD11c+CD103+DCs and semi‐mature DCs reduce BLG allergic reactions.Significance and Impact of the StudyThese data confirm that BBMN68 may be a suitable therapeutic approach to the alleviation of food allergies, and BBMN68‐specific induction of CD11c+CD103+DCs and semi‐mature DCs are associated with this protection.
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