Publisher： John Wiley & Sons Inc
E-ISSN： 1476-5381|71|1|75-81
ISSN： 0007-1188
Source： BRITISH JOURNAL OF PHARMACOLOGY (ELECTRONIC), Vol.71, Iss.1, 1980-01, pp. : 75-81
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Abstract
1Effects of prostaglandins E2 and F2α (PGE2 and PGF2α) on vasoconstrictor responses to noradrenaline (NA) and methoxamine in isolated mesenteric arteries of the rat were investigated.2PGE2 and to a lesser extent PGF2α potentiated vasoconstrictor responses to NA and methoxamine.3Prior treatment with reserpine increased, and bretylium reduced, the extent of potentiation significantly.4NA vasoconstriction persisted for 1 h after Ca2+ was removed from the perfusing Krebs solution. Prostaglandin‐induced potentiation was absent in Ca2+‐free Krebs, but increased proportionately with increase in external Ca2+ concentration.5Vasoconstriction induced by high potassium, was not potentiated by PGE2.6It is concluded that PGE2 potentiates NA vasoconstriction by facilitating Ca2+ influx.
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