Publisher: John Wiley & Sons Inc
E-ISSN: 1365-2141|94|2|379-382
ISSN: 0007-1048
Source: BRITISH JOURNAL OF HAEMATOLOGY, Vol.94, Iss.2, 1996-08, pp. : 379-382
Disclaimer: Any content in publications that violate the sovereignty, the constitution or regulations of the PRC is not accepted or approved by CNPIEC.
Abstract
Fas ligand (FasL), either in the membrane bound form or soluble form, has cytotoxic activity against Fas‐expressing cells. We report a case of nasal lymphoma accompanied by liver damage and pancytopenia. The serum level of soluble FasL (sFasL) was very high on admission, but rapidly decreased to normal levels after chemotherapy for lymphoma. Liver damage and pancytopenia also improved with the decrease in serum sFasL. Since Fas is expressed on both hepatocytes and haemopoietic cells, these facts suggest that FasL was expressed on lymphoma cells and directly associated with pathogenesis of liver damage and pancytopenia through its cytotoxic activity.
Related content
An aggressive nasal lymphoma accompanied by high levels of soluble Fas ligand
BRITISH JOURNAL OF HAEMATOLOGY, Vol. 7-1048, Iss. 2, 1996-08 ,pp. :
Acta Haematologica, Vol. 103, Iss. 3, 2000-08 ,pp. :