Publisher： John Wiley & Sons Inc
E-ISSN： 1439-7633|16|7|1115-1119
ISSN： 1439-4227
Source： CHEMBIOCHEM, Vol.16, Iss.7, 2015-05, pp. : 1115-1119
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Abstract
AbstractExchange of the native promoter to the arabinose‐inducible promoter PBAD was established in entomopathogenic bacteria to silence and/or activate gene clusters involved in natural product biosynthesis. This allowed the “on‐demand” production of GameXPeptides, xenoamicins, and the blue pigment indigoidine. The gene clusters for the novel “mevalagmapeptides” and the highly toxic xenorhabdins were identified by this approach.
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