Publisher： John Wiley & Sons Inc
E-ISSN： 1521-3773|54|27|7891-7894
ISSN： 1433-7851
Source： ANGEWANDTE CHEMIE INTERNATIONAL EDITION, Vol.54, Iss.27, 2015-06, pp. : 7891-7894
Disclaimer: Any content in publications that violate the sovereignty, the constitution or regulations of the PRC is not accepted or approved by CNPIEC.
Abstract
AbstractA RhI‐catalyzed three‐component reaction of tert‐propargyl alcohol, diazoester, and alkyl halide has been developed. This reaction can be considered as a carbene‐involving sequential alkyl and alkynyl coupling, in which C(sp)C(sp3) and C(sp3)C(sp3) bonds are built successively on the carbenic carbon atom. The RhI‐carbene migratory insertion of an alkynyl moiety and subsequent alkylation are proposed to account for the two separate CC bond formations. This reaction provides an efficient and tunable method for the construction of all‐carbon quaternary center.
Related content
Access to resources
Recommend
Rhodium(III)‐Catalyzed Amidation of Unactivated C(sp3)H Bonds
ANGEWANDTE CHEMIE INTERNATIONAL EDITION, Vol. 54, Iss. 44, 2015-10 ,pp. :
Rhodium(III)‐Catalyzed Amidation of Unactivated C(sp3)H Bonds
ANGEWANDTE CHEMIE, Vol. 127, Iss. 44, 2015-10 ,pp. :
Development of a Rhodium(II)‐Catalyzed Chemoselective C(sp3)H Oxygenation
CHEMISTRY - A EUROPEAN JOURNAL, Vol. 21, Iss. 42, 2015-10 ,pp. :