One‐Pot Synthesis of Symmetrical 2,6‐Diarylpyridines via Palladium/Copper‐Catalyzed Sequential Decarboxylative and Direct CH Arylation

Publisher: John Wiley & Sons Inc

E-ISSN: 1615-4169|357|6|1143-1148

ISSN: 1615-4150

Source: ADVANCED SYNTHESIS & CATALYSIS, Vol.357, Iss.6, 2015-04, pp. : 1143-1148

Disclaimer: Any content in publications that violate the sovereignty, the constitution or regulations of the PRC is not accepted or approved by CNPIEC.

Previous Menu Next

Abstract

AbstractA palladium(II)/copper oxide (Cu2O)‐catalyzed one‐pot decarboxylative and direct CH arylation of 2‐picolinic acid with aryl bromides has been developed. Various aryl bromides have been shown to be efficient coupling partners in the presence of dimethyl sulfate, furnishing symmetrical 2,6‐diarylpyridines in moderate to good yields.