NEUROBIOLOGY OF MEN'S MENTAL HEALTH

NEUROBIOLOGY OF MEN'S MENTAL HEALTH

Library of Congress Cataloging-in-Publication Data

CONTENTS

PREFACE

SECTION ONE: MEN'S MENTAL HEALTH IN CHILDHOOD, ADOLESCENCE, AND NEURODEVELOPMENT

Chapter 1 TESTOSTERONE AND MALE DEVELOPMENT

ABSTRACT

INTRODUCTION

NORMATIVE PHYSIOLOGY OF TESTOSTERONE

PRELIMINARY EVIDENCE REGARDING THE ROLE OF TESTOSTERONE IN MALE CNS DEVELOPMENT

REFERENCES

Chapter 2 TESTOSTERONE, EMOTION REGULATION, AND ENDOPHENOTYPES

ABSTRACT

INTRODUCTION

EMOTION REGULATION AND THE INDIVIDUAL

ER AND DEVELOPMENT

ER DEFICITS IN THE COMMON PRESENTATIONS OF MALE CHILDREN, ADOLESCENTS, AND ADULTS

SEX HORMONES, ER, AND AN ENDOPHENOTYPE OF MEN'S MENTAL HEALTH

CONCLUSION

REFERENCES

Chapter 3 FUTURE DIRECTIONS CONCERNING THE IMPACT OF CHILDHOOD AND ADOLESCENT ADVERSITIES IN THE FIELD OF MEN’S MENTAL HEALTH: THE NEW YORK DECLARATION

ABSTRACT

1. TARGETS OF ABUSE AND VICTIMS OF TRAUMA

2. NEURAL VULNERABILITY

3. ENDOCRINOLOGICAL VULNERABILITY

4. EXTERNALIZING BEHAVIOR

5. THE JUSTICE SYSTEM

CONFLICT OF INTEREST STATEMENT

REFERENCES

Chapter 4 NEUROBIOLOGICAL BASIS OF ATTENTION DEFICIT HYPERACTIVITY DISORDER (ADHD). ARE MALES DIFFERENT?

ABSTRACT

INTRODUCTION

GENDER DIFFERENCES IN ADHD SYMPTOMS AND COMORBID NEURODEVELOPMENTAL AND OTHER PSYCHIATRIC DISORDERS

PATHOPHYSIOLOGY OF ADHD IN THE CONTEXT OF GENDER DIFFERENCES

Genetic Substrates of ADHD

Neuroimaging Studies of ADHD

CONCLUSION

REFERENCES

Chapter 5 MENTAL HEALTH SERVICE USE BY SUICIDAL BOYS AND GIRLS

ABSTRACT

INTRODUCTION

Terminology

MENTAL HEALTH SERVICE USE AND THE CONTINUUM OF SUICIDAL BEHAVIOR IN BOYS AND GIRLS

Mental Health Service Use and Suicide Attempts in the Community in Boys and Girls

Mental Health Service Use and Hospital Presentations in Boys and Girls

Mental Health Service Use and Suicide in Boys and Girls

CONCLUSION

REFERENCES

Chapter 6 ALL JUST FUN AND GAMES? MEN AND MEDIA VIOLENCE

ABSTRACT

INTRODUCTION

Summary of the Research on the Effects of Violent Video Games

The Male Brain and Aggression

Impact of Gaming on Functioning and Interpersonal Relationships

Video Game Content

CONCLUSION

REFERENCES

Chapter 7 PHYSIOLOGICAL AND PSYCHOLOGICAL ASSOCIATIONS OF TESTOSTERONE IN SPORTS AND EXERCISE WITH DUE REGARD TO ADOLESCENTS

ABSTRACT

INTRODUCTION

Biosynthesis and Regulation of Testosterone

Testosterone Levels and Age

Testosterone and Sports and Exercise

Testosterone and Motor Performance

Testosterone and Acute Bouts of Exercise

Testosterone and Acute Bouts of Endurance Exercise

Testosterone and Acute Bouts of Resistance Exercise

Testosterone and Chronic Exercise/ Training

Testosterone and Endurance Training

Testosterone and Resistance Training

Testosterone and Psychological Associations

Testosterone and Dominance and Aggression

Testosterone, Anxiety, and Depression

Testosterone and Motivation

Testosterone and Cognition

CONCLUSION

REFERENCES

Chapter 8 THE EFFECTS OF HIGH-FAT DIET (WITH AND WITHOUT WEIGHT GAIN) ON TESTOSTERONE LEVELS (PUBERTAL PERSPECTIVE)

REFERENCES

Chapter 9 INTEGRATING CHILD AND ADOLESCENT PSYCHOTHERAPY WITH MALE NEUROBIOLOGY: REGULATION-FOCUSED PSYCHOTHERAPY FOR CHILDREN

ABSTRACT

INTRODUCTION

IMPLICIT AND EXPLICIT ER

THERAPEUTIC RELEVANCE FOR MEN'S MENTAL HEALTH

REGULATION FOCUSED PSYCHOTHERAPY FOR CHILDREN

VIGNETTE

CONCLUSION

REFERENCES

Chapter 10 REGULATION-FOCUSED PSYCHOTHERAPY FOR CHILDREN IN MEDICAL EDUCATION: AN ACCOUNT FROM THE PERSPECTIVE OF MEN'S MENTAL HEALTH

ABSTRACT

INTRODUCTION

THE PROBLEM OF MEDICAL STUDENT RECRUITMENT INTO CHILD AND ADOLESCENT PSYCHIATRY

MEDICAL STUDENT PERSPECTIVES AND ATTEMPTED INTERVENTIONS TO IMPROVE RECRUITMENT

EXAMPLE OF RFP-C APPLICATION IN STUDENT TEACHING

PSYCHOANALYSIS AND ITS RELEVANCE IN MEDICAL STUDENT EDUCATION

CONCLUSION

REFERENCES

Chapter 11 REGULATION-FOCUSED PSYCHOTHERAPY FOR CHILDREN IN GENERAL PSYCHIATRIC EDUCATION: AN ACCOUNT FROM THE PERSPECTIVE OF MEN'S MENTAL HEALTH

ABSTRACT

INTRODUCTION

Proposal

Disclaimer

Background

Methods

RESULTS

DISCUSSION

Psychoanalytic Considerations

CONCLUSION AND SUMMARY

REFERENCES

SECTION TWO: SUICIDE AND HOMICIDE IN MEN

Chapter 12 SEX DIFFERENCES IN SUICIDE RATES FROM THE PERSPECTIVE OF PSYCHIATRIC CARE TAILORED TO MEN

ABSTRACT

INTRODUCTION

SEX DIFFERENCES IN SUICIDALITY

NEUROTRANSMITTER AND SUICIDALITY

SEX HORMONE AND SUICIDALITY

PREVENTION OF MALE SUICIDE

CONCLUSION

REFERENCES

Chapter 13 MALE SUICIDAL BEHAVIOR

ABSTRACT

INTRODUCTION

The Gender Paradox

Risk Factors

Mental Disorders

Alcoholism

Depression

Personality Disorders

PSYCHOLOGICAL DIMENSIONS

Aggression and Impulsivity

SOCIOECONOMIC FEATURES AND STRESSFUL EVENTS

Sexual Abuse

Work-Related Factors

Widowhood

Divorce or Separation

Old Age

FEATURES OF MALE SUICIDE

Method of Suicide

Previous Suicide Attempts

Level of Suicidal Intent

TREATMENT SEEKING AND STIGMA

DISCUSSION

CONCLUSION

REFERENCES

Chapter 14 PLASMA TESTOSTERONE DIFFERENCES BETWEEN SUICIDE ATTEMPTERS AND COMMUNITY CONTROLS IN BOTH MEN AND WOMEN OF CHINA

ABSTRACT

INTRODUCTION

METHODS

Study Population and Procedure

Testosterone Measurement

Social Psychological and Demographic Measures

Statistical Procedures

Ethical Issues

RESULTS

DISCUSSION

REFERENCES

Chapter 15 MALE SUICIDALITY ACROSS THE LIFESPAN

ABSTRACT

INTRODUCTION AND EPIDEMIOLOGY

FROM CHILDHOOD TO PUBERTY

STRESS

DEPRESSION

SOCIAL RELATIONSHIPS

AVAILABILITY

PSYCHOLOGICAL EXPLANATION

GERIATRICS

CONCLUSION

REFERENCES

Chapter 16 TESTOSTERONE AND HOMICIDE AMONG YOUNG MEN

ABSTRACT

INTRODUCTION

DISTINGUISHING DOMINANCE FROM AGGRESSION

TESTOSTERONE WORKS DIFFERENTLY IN UTERO, PUBERTY, AND ADULTHOOD

RECIPROCAL CAUSATION

DOMINANCE CONTESTS

MURDER

CONCLUSION

REFERENCES

Chapter 17 SUICIDAL TERRORISM: PSYCHIATRIC ASPECTS

ABSTRACT

INTRODUCTION

SUICIDE TERRORISM

PSYCHIATRIC ASPECTS

Education and Training

Suicide Terrorists are Mentally Stable

Suicide Terrorists Have Psychiatric Problems

CONCLUSION

REFERENCES

Chapter 18 HOMICIDAL TERRORISM: PSYCHIATRIC ASPECTS

ABSTRACT

INTRODUCTION

METHODS

FINDINGS

PROMISE VS. REALITY

PSYCHOPATHOLGY

RESEARCH SUGGESTIONS

CONCLUSION

REFERENCES

SECTION THREE: MAJOR MENTAL ILLNESS IN MEN

Chapter 19 POSTTRAUMATIC STRESS DISORDER IN MEN: PSYCHOSOCIAL, CULTURAL AND NEUROBIOLOGICAL FACTORS

ABSTRACT

INTRODUCTION

DEFINING POSTTRAUMATIC STRESS DISORDER

NEUROBIOLOGICAL FACTORS

OTHER PSYCHOSOCIAL AND CULTURAL FACTORS

COMORBIDITY

EXPOSURE TO TRAUMATIC EVENTS

TYPE OF TRAUMA EXPOSURE

PREVALENCE IN THE GENERAL POPULATION

POPULATIONS EXPOSED TO MASS CONFLICT

NATURAL OR MAN-MADE DISASTERS

MILITARY PERSONNEL

MILITARY SEXUAL TRAUMA

FIRST RESPONDERS AND RESCUE WORKERS

CONCLUSION

REFERENCES

Chapter 20 TRAUMATIC BRAIN INJURY

ABSTRACT

I. EPIDEMOLOGY/ETIOLOGY

II. PATHOPHYSIOLOGY

III. COURSE OF ILLNESS

IV. NEUROPSYCHIATRIC SEQUELAE

Cognitive

Motivation

Depression

Mania, Hypomania, and Mixed Disorder

Psychosis

Anxiety Disorders

Aggressive Disorders

Substance Use Disorders

CONCLUSION

REFERENCES

Chapter 21 SUICIDAL BEHAVIOR IN MEN WITH COMORBID DEPRESSION AND SUBSTANCE USE DISORDERS: ROLES OF ACTIVE SUBSTANCE USE, EXPOSURE TO COMBAT IN THE MILITARY, AND ALTERATIONS IN TESTOSTERONE LEVELS

ABSTRACT

INTRODUCTION

Case #1 – A Young Military Veteran

Case #2 – A Former Nurse Practitioner

Discussion and Conclusions

REFERENCES

SECTION FOUR: MEN’S HEALTH: MEDICAL ISSUES AND FUTURE DIRECTIONS

Chapter 22 TESTOSTERONE AND MALE REPRODUCTIVE HEALTH

ABSTRACT

LIST OF ABBREVIATIONS

1. INTRODUCTION

2. SYNTHESIS AND KINETICS OF TESTOSTERONE

3. HYPOTHALAMIC-PITUATARY-GONADAL AXIS

4. TESTOSTERONE AND SPERMATOGENESIS

5. HYPOGONADISM

5.1. Hypogonadotropic Hypogonadism

5.2. Congenital Adrenal Hyperplasia

5.3. Hypogonadism Secondary to Congenital Abnormalities

5.3.1. Prader-Willi Syndrome

5.3.2. Klinefelter’s Syndrome

5.4. Exogenous Testosterone-associated Infertility

CONCLUSION

REFERENCES

Chapter 23 TESTOSTERONE AND MALE CARDIOVASCULAR HEALTH

ABSTRACT

1. INTRODUCTION

2. TESTOSTERONE AND CARDIOVASCULAR DISEASE

2.1. Testosterone and Coronary Heart Disease

2.2. Testosterone and Cerebrovascular Disease: Stroke and Transient Ischemic Attack

2.3. Testosterone, Aortic Atherosclerosis/Aneurysm, and Peripheral Vascular Disease

3. TESTOSTERONE AND METABOLIC SYNDROME

4. TESTOSTERONE SUPPLEMENTATION THERAPY

4.1. Effect of Testosterone Supplemetation on ST Depression/Ischemia

4.2. Effect of Testosterone Supplementation on CHF Exercise Tolerance

5. RISKS OF TESTOSTERONE THERAPY

6. MECHANISTIC EFFECT OF TESTOSTERONE ON CARDIOVASCULAR SYSTEM

6.1. Endothelial Dysfunction

6.2. Inflammation

6.3. Clotting

7. SUMMARY OF THE EFFECT OF TESTOSTERONE ON CARDIOVASCULAR DISEASE

CONCLUSION

REFERENCES

Chapter 24 STEROID SECRETION AND PSYCHOLOGICAL WELL-BEING IN MEN 40+

ABSTRACT

INTRODUCTION

HORMONAL CHANGES IN MEN AGED OVER 40 YEARS

BIOLOGICAL MECHANISMS UNDERLYING AGE-RELATED HORMONAL ALTERATIONS

CONSEQUENCES OF AGE-RELATED HORMONAL CHANGES

Psychological Consequences: Well-being and Depression

Sexual Consequences: Erectile Function and Sexual Desire

Cognitive Consequences: Cognition and Dementia

PHYSICAL CONSEQUENCES: BODY COMPOSITION AND FRAILTY

CLINICAL IMPLICATIONS

Hormone Replacement

GENERAL HEALTH AND SUCCESSFUL AGING

CONCLUSION

REFERENCES

Chapter 25 FUTURE RESEARCH AND CLINICAL DIRECTIONS IN THE FIELD OF MEN'S MENTAL HEALTH: THE MADRID DECLARATION

ABSTRACT

INTRODUCTION

HELP-SEEKING BEHAVIOR

IMPULSIVITY

ALCOHOL AND DRUG ABUSE IN MEN

WORK RELATED STRESS

BEREAVEMENT

HORMONES

PHARMACOKINETICS

SOCIAL AWARENESS

CONFLICT OF INTEREST STATEMENT

REFERENCES

INDEX