Contents

Contributors

Preface

I: Hazard Identification

1 Microbial Flora of Humans and Microbial Virulence Factors

2 Indigenous and Pathogenic Agents of Research Animals

3 Laboratory, Growth Chamber, and Greenhouse Microbial Safety: Plant Pathogens and Plant-Associated Microorganisms of Significance to Human Health

4 Epidemiology of Laboratory-Associated Infections

II: Hazard Assessment

5 Risk Assessment of Biological Hazards

6 Bacterial Pathogens

7 Protozoa and Helminths

8 Mycotic Agents of Human Disease

9 Viral Agents of Human Disease: Biosafety Concerns

10 Biosafety for Microorganisms Transmitted Primarily by the Airborne Route

11 Cell Lines: Applications and Biosafety

12 Allergens of Animal and Biological Systems

13 Biological Toxins: Safety and Science

III: Hazard Control

14 Design of Biomedical Laboratory Facilities

15 Primary Barriers and Equipment-Associated Hazards

16 Primary Barriers: Biological Safety Cabinets, Fume Hoods, and Glove Boxes

17 Personal Respiratory Protection

18 Standard (Universal) Precautions for Handling Human Specimens

19 Prudent Biosafety Practices

20 Decontamination and Disinfection

21 Packing and Shipping Biological Materials

IV: Administrative Controls

22 Biological Safety Program Management

23 Biosafety Compliance: a Global Perspective

24 Occupational Medicine in a Biomedical Research Setting

25 Measuring Biosafety Program Effectiveness

V: Special Considerations for Biosafety

26 Biosafety of Prion Diseases

27 Safety Considerations in the BSL-4 Maximum-Containment Laboratory

28 Biosafety and Viral Gene Transfer Vectors

29 Biosafety in the Teaching Laboratory

30 Biosafety in the Pharmaceutical Industry

31 Large-Scale Production of Microorganisms

32 Special Considerations for Agriculture Pathogen Biosafety

33 Biosafety and Biosecurity: Regulatory Impact

Index

A

B

C

D

E

F

G

H

I

J

K

L

M

N

O

P

Q

R

S

T

U

V

W

X

Y

Z