Bacterial Ion Channels and Their Eukaryotic Homologs

Author: Kubalski   Martinac  

Publisher: American Society for Microbiology‎

Publication year: 2005

E-ISBN: 9781555816452

P-ISBN(Hardback):  9781555813284

Subject: Q24 cell morphology

Language: ENG

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Chapter

Chapter 1. K+ Channels: a Survey and a Case Study of Kch of Escherichia coli

THE INVISIBLE BIOLOGICAL WORLD

THE IMPORTANCE OF K+

A MENAGERIE OF K+ CHANNELS

TECHNICAL CHALLENGES

Kch, THE K+ CHANNEL OF E. COLI

PERSPECTIVE

Chapter 2. The Ktn Domain and Its Role as a Channel and Transporter Regulator

STRUCTURE OF THE Ktn DOMAIN

ROLE OF Ktn DOMAINS IN REGULATION OF TRANSPORT

Chapter 3. Deciphering Streptomyces lividans KcsA as a K Channel Model

GENERAL FEATURES OF STREPTOMYCETES

IDENTIFICATION OF KcsA

CHANNEL ACTIVITY WITHIN GIANT PROTOPLAST VESICLES

HIGH SYNTHESIS LEVELS AND PURIFICATION OF KcsA

FUNCTIONAL RECONSTITUTION IN A BILAYER

OLIGOMERIZATION OF KcsA

GENERAL FEATURES OF THE RECONSTITUTED FUNCTIONAL KcsA CHANNEL

CHANNEL OPENING AND CATION SELECTIVITY AT LOW pH

EFFECTS OF ELECTROCHEMICAL GRADIENT, pH, AND TEMPERATURE ON OPENING AND SELECTIVITY

AMINO ACIDS AFFECTING ASSEMBLY AND ACTIVITY

DYNAMIC CHANGES WITHIN THE PERMEATION PATHWAY

INTERACTION OF KcsA WITH PHOSPHOLIPIDS

ASSEMBLY OF KcsA WITHIN THE INNER MEMBRANE OF AN E. COLI HOST

INTERACTION OF KcsA WITH NONPROTEIN MOLECULES FROM AN E. COLI HOST

MODULE SHUFFLING AMONG KcsA AND EUKARYOTIC CHANNEL PROTEINS

CLOSE AND DISTANT RELATIVES OF KcsA

THE CRYSTAL STRUCTURE OF KcsA: AN OPEN OR CLOSED CHANNEL?

VIRAL Kcv CHANNELS ARE SMALLER THAN KcsA

Chapter 4. The Molecular Basis of K+ Channel Gating

CORE CHANNEL DOMAIN STRUCTURE

KcsA CHANNEL GATING

K+ CHANNEL OPEN STRUCTURES

RCK DOMAIN-CONTAINING CHANNELS

CONFORMATIONAL MOVEMENT OF RCK DOMAINS AND GATING

Chapter 5. Glutamate-Activated Channels

ANIMAL GLUTAMATE RECEPTORS

PROKARYOTIC GLUTAMATE RECEPTORS

PLANT GLUTAMATE RECEPTORS

EVOLUTIONARY RELATIONSHIP

Chapter 6. Voltage-Gated K+ Channels

KvAP CRYSTAL STRUCTURE

TRANSMEMBRANE TOPOLOGY

CREVASSE MODELS OF ACTIVATION GATING

MODELS BASED ON THE CRYSTAL STRUCTURE OF THE ISOLATED VOLTAGE-SENSING DOMAIN OF KvAP

OTHER TYPES OF PROKARYOTIC Kv CHANNELS

Chapter 7. Inward Rectifier K+ Channels

MOLECULAR DIVERSITY

MOLECULAR STRUCTURE

MOLECULAR EVOLUTION

Chapter 8. From Prokaryotes to Eukaryotes: Molecular Modeling and Simulation Studies of Ion Channels

POTASSIUM CHANNELS

GLUTAMATE RECEPTORS

Chapter 9. Towards an Understanding of Membrane Channels

METHODS

PERMEATION AND SELECTIVITY IN AQUAPORIN WATER CHANNELS

ION AND WATER PERMEATION IN ALPHA-HEMOLYSIN

PERMEATION AND GATING OF MECHANOSENSITIVE CHANNELS

Chapter 10. Bacterial Na Channels: Progenitors, Progeny, or Parallel Evolution?

A FAMILY OF VOLTAGE-GATED BACTERIAL SODIUM CHANNELS

NaChBac OR CaChBac? FROM SEQUENCE TO FUNCTION

PROSPECTS FOR THE FUTURE: A NEW BIOPHYSICAL MODEL

Chapter 11. The CLC Family of Proteins: Chloride Transporters and Channels

SOME GENERAL CHARACTERISTICS OF THIS FAMILY

EVOLUTIONARY RELATIONSHIPS

ACTION POTENTIALS

THE MUSCLE-TYPE CLC CHANNELS (ClC-0 AND ClC-1)

PEPTIDE MOTIFS IN ClC-Hs1

NONVERTEBRATE CLC PROTEINS

ROLE OF CLC CHLORIDE CHANNELS IN DISEASE

THERAPY AND CLC CHANNELS

Chapter 12. The Bacterial Mechanosensitive Channel MscS and Its Extended Family

THE DISCOVERY OF MscS

CHARACTERIZING MscS ACTIVITY

UNEARTHING THE mscS GENE

REVEALING STRUCTURAL FEATURES OF THE MscS PROTEIN

MODELS FOR GATING AND MODULATING MscS ACTIVITY

THE MscS EXTENDED FAMILY: SPECULATION OF FUNCTION AND FORM

Chapter 13. MscL, a Bacterial Mechanosensitive Channel

BACTERIAL MECHANOSENSITIVE CHANNELS AS MODEL SYSTEMS

PREPARATIONS FOR BACTERIAL CHANNEL RECORDING

IDENTIFICATION OF MscL

MscL PROTEIN

HOMOLOGS OF MscL

STRUCTURE OF TbMscL

MscL ACTIVITIES IN NATIVE MEMBRANES AND LIPOSOMES

PROBING THE STRUCTURE

MODELS OF THE GATING

EXPERIMENTS VERSUS MODELS

CURRENT TRENDS AND PERSPECTIVES

Chapter 14. The Role of Bacterial Channels in Cell Physiology

POTENTIAL ROLES OF BACTERIAL ION CHANNELS

ESTABLISHED FUNCTIONS OF ION CHANNELS IN BACTERIAL PHYSIOLOGY

MS CHANNELS

CHLORIDE CHANNELS

GLUTATHIONE-GATED K+ EFFLUX SYSTEMS

SOLUTE-SPECIFIC (GATED) PORES

Index

Color Plates

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