Contents

Contributors

Preface

I. Second Messengers: an Overview

1. Introduction to Second Messengers: Lessons from Cyclic AMP

II. General Principles: the Core

2. Moshe Benziman and the Discovery of Cyclic Di-GMP

3. Ubiquity of Cyclic Di-GMP Pathways: a Bioinformatic Analysis

4. The Core Pathway: Diguanylate Cyclases, Cyclic Di-GMP-Specific Phosphodiesterases, and Cyclic Di-GMP-Binding Proteins

5. The HD-GYP Domain and Cyclic Di-GMP Signaling

6. Methods for Cyclic Di-GMP Detection

7. Making, Breaking, and Sensing of Cyclic Di-GMP: Structural, Thermodynamic, and Evolutionary Principles

III. Cyclic Di-GMP and Lifestyle Choices

8. Choosing the Right Lifestyle: Regulation of Developmental Pathways by Cyclic Di-GMP

9. Role of Cyclic Di-GMP in Caulobacter crescentus Development and Cell Cycle Control

10. Hierarchical Control of rdar Morphotype Development of Salmonella enterica by Cyclic Di-GMP

11. Role of Cyclic Di-GMP in Pseudomonas aeruginosa Biofilm Development

12. The Scr Circuit in Vibrio parahaemolyticus Modulates Swarming and Sticking

13. Roles of Diguanylate Cyclases and Phosphodiesterases in Motility and Biofilm Formation in Vibrio fischeri

14. Csr (Rsm) System and Its Overlap and Interplay with Cyclic Di-GMP Regulatory Systems

15. Riboswitches That Sense Cyclic Di-GMP

16. Role of Cyclic Di-GMP in the Regulatory Networks of Escherichia coli

17. Cyclic Di-GMP Signaling in Vibrio cholerae

18. Role of Cyclic Di-GMP in Biofilm Development and Signaling in Yersinia pestis

19. Environmental Control of Cyclic Di-GMP Signaling in Pseudomonas fluorescens: from Signal to Output

IV. Cyclic Di-GMP, Pathogenesis, and Host Immunity

20. Role of Cyclic Di-GMP in Vibrio cholerae Virulence

21. Cyclic Di-GMP Signaling and Host Immunity

22. Bis-(3',5')-Cyclic Di-GMP: Promising Adjuvant for Vaccine Design

V. Conclusions

23. Cyclic Di-GMP: Using the Past To Peer into the Future

Index

A

B

C

D

E

F

G

H

I

K

L

M

N

O

P

Q

R

S

T

U

V

W

X

Y