Cover

Cover

Cover

Half Title

Half Title

Half Title

Title

Title

Title

Copyright

Copyright

Copyright

Dedication

Dedication

Dedication

Contents

Contents

Contents

Preface

Preface

Preface

1 Principles and Approaches

1 Principles and Approaches

1 Principles and Approaches

Introduction

Introduction

Introduction

Definitions

Definitions

Definitions

Differentiating Molecular Epidemiology from Taxonomy and Phylogeny

Differentiating Molecular Epidemiology from Taxonomy and Phylogeny

Differentiating Molecular Epidemiology from Taxonomy and Phylogeny

Epidemiologic Problems Addressed by Molecular Strain-Typing Techniques

Epidemiologic Problems Addressed by Molecular Strain-Typing Techniques

Epidemiologic Problems Addressed by Molecular Strain-Typing Techniques

Application to Epidemiology of Molecular Strain-Typing Methods

Application to Epidemiology of Molecular Strain-Typing Methods

Application to Epidemiology of Molecular Strain-Typing Methods

Concluding Remarks

Concluding Remarks

Concluding Remarks

2 Laboratory Methods Used for Strain Typing of Pathogens: Conventional and Molecular Techniques

2 Laboratory Methods Used for Strain Typing of Pathogens: Conventional and Molecular Techniques

2 Laboratory Methods Used for Strain Typing of Pathogens: Conventional and Molecular Techniques

Introduction

Introduction

Introduction

Phenotypic Strain-Typing Methods

Phenotypic Strain-Typing Methods

Phenotypic Strain-Typing Methods

Genotypic Strain-Typing Methods

Genotypic Strain-Typing Methods

Genotypic Strain-Typing Methods

Concluding Remarks

Concluding Remarks

Concluding Remarks

3 Laboratory Methods Used for Strain Typing of Pathogens: PCR-Based Strain-Typing Methods

3 Laboratory Methods Used for Strain Typing of Pathogens: PCR-Based Strain-Typing Methods

3 Laboratory Methods Used for Strain Typing of Pathogens: PCR-Based Strain-Typing Methods

Introduction

Introduction

Introduction

Epidemiologic Application of PCR-Based Strain-Typing Methods

Epidemiologic Application of PCR-Based Strain-Typing Methods

Epidemiologic Application of PCR-Based Strain-Typing Methods

Strain-Typing Methods Based on PCR Assays

Strain-Typing Methods Based on PCR Assays

Strain-Typing Methods Based on PCR Assays

Concluding Remarks

Concluding Remarks

Concluding Remarks

4 Analysis of Similarity and Relatedness in Molecular Epidemiology

4 Analysis of Similarity and Relatedness in Molecular Epidemiology

4 Analysis of Similarity and Relatedness in Molecular Epidemiology

Introduction

Introduction

Introduction

Methods of Classification

Methods of Classification

Methods of Classification

Assessing Validity and Reliability of Relationship Measures

Assessing Validity and Reliability of Relationship Measures

Assessing Validity and Reliability of Relationship Measures

Computer-Assisted Analyses of Pathogen Relationships

Computer-Assisted Analyses of Pathogen Relationships

Computer-Assisted Analyses of Pathogen Relationships

Concluding Remarks

Concluding Remarks

Concluding Remarks

5 Distinguishing between Epidemic and Endemic Occurrences of Infectious Diseases

5 Distinguishing between Epidemic and Endemic Occurrences of Infectious Diseases

5 Distinguishing between Epidemic and Endemic Occurrences of Infectious Diseases

Introduction

Introduction

Introduction

Endemic versus Epidemic Occurrences of Infectious Disease

Endemic versus Epidemic Occurrences of Infectious Disease

Endemic versus Epidemic Occurrences of Infectious Disease

Epidemiology of Antimicrobial Drug-Resistant Pathogens

Epidemiology of Antimicrobial Drug-Resistant Pathogens

Epidemiology of Antimicrobial Drug-Resistant Pathogens

Epidemiology of Drug-Susceptible Infectious Diseases

Epidemiology of Drug-Susceptible Infectious Diseases

Epidemiology of Drug-Susceptible Infectious Diseases

Concluding Remarks

Concluding Remarks

Concluding Remarks

6 Stratification and Refinement of Data in Epidemiologic Investigations

6 Stratification and Refinement of Data in Epidemiologic Investigations

6 Stratification and Refinement of Data in Epidemiologic Investigations

Introduction

Introduction

Introduction

Characterizing Dynamics of Infectious Disease Transmission in Community Settings

Characterizing Dynamics of Infectious Disease Transmission in Community Settings

Characterizing Dynamics of Infectious Disease Transmission in Community Settings

Determining Attributable Risks in Community- or Institution-Acquired Infections

Determining Attributable Risks in Community- or Institution-Acquired Infections

Determining Attributable Risks in Community- or Institution-Acquired Infections

Refining Analytical Epidemiologic Study Designs

Refining Analytical Epidemiologic Study Designs

Refining Analytical Epidemiologic Study Designs

Concluding Remarks

Concluding Remarks

Concluding Remarks

7 Distinguishing Pathovars from Nonpathovars: Escherichia coli

7 Distinguishing Pathovars from Nonpathovars: Escherichia coli

7 Distinguishing Pathovars from Nonpathovars: Escherichia coli

Introduction

Introduction

Introduction

E. coli Classifications

E. coli Classifications

E. coli Classifications

E. coli Associated with Intestinal Diseases

E. coli Associated with Intestinal Diseases

E. coli Associated with Intestinal Diseases

Extraintestinal E. coli Infections

Extraintestinal E. coli Infections

Extraintestinal E. coli Infections

Concluding Remarks

Concluding Remarks

Concluding Remarks

8 Distinguishing Pathovars from Nonpathovars: Streptococcus pneumoniae

8 Distinguishing Pathovars from Nonpathovars: Streptococcus pneumoniae

8 Distinguishing Pathovars from Nonpathovars: Streptococcus pneumoniae

Introduction

Introduction

Introduction

S. pneumoniae (the Pneumococcus)

S. pneumoniae (the Pneumococcus)

S. pneumoniae (the Pneumococcus)

Application of Strain-Typing Methods to Epidemiologic Investigation of Pneumococcal Infections

Application of Strain-Typing Methods to Epidemiologic Investigation of Pneumococcal Infections

Application of Strain-Typing Methods to Epidemiologic Investigation of Pneumococcal Infections

Concluding Remarks

Concluding Remarks

Concluding Remarks

9 Distinguishing Pathovars from Nonpathovars: Helicobacter pylori

9 Distinguishing Pathovars from Nonpathovars: Helicobacter pylori

9 Distinguishing Pathovars from Nonpathovars: Helicobacter pylori

Introduction

Introduction

Introduction

H. pylori

H. pylori

H. pylori

Application of Strain-Typing Methods to Epidemiologic Investigation of H. pylori Infections

Application of Strain-Typing Methods to Epidemiologic Investigation of H. pylori Infections

Application of Strain-Typing Methods to Epidemiologic Investigation of H. pylori Infections

Concluding Remarks

Concluding Remarks

Concluding Remarks

10 Hospital Infections: Staphylococcus aureus

10 Hospital Infections: Staphylococcus aureus

10 Hospital Infections: Staphylococcus aureus

Introduction

Introduction

Introduction

Overview of Clinical and Epidemiologic Issues Related to Bacterial Nosocomial Infections

Overview of Clinical and Epidemiologic Issues Related to Bacterial Nosocomial Infections

Overview of Clinical and Epidemiologic Issues Related to Bacterial Nosocomial Infections

Staphylococcal Nosocomial Infections

Staphylococcal Nosocomial Infections

Staphylococcal Nosocomial Infections

Strain-Typing Methods for S. aureus

Strain-Typing Methods for S. aureus

Strain-Typing Methods for S. aureus

Application of Strain-Typing Methods to Epidemiologic Investigation of Nosocomial S. aureus Infections

Application of Strain-Typing Methods to Epidemiologic Investigation of Nosocomial S. aureus Infections

Application of Strain-Typing Methods to Epidemiologic Investigation of Nosocomial S. aureus Infections

Concluding Remarks

Concluding Remarks

Concluding Remarks

11 Hospital Infections: Gram-Negative Bacteria

11 Hospital Infections: Gram-Negative Bacteria

11 Hospital Infections: Gram-Negative Bacteria

Introduction

Introduction

Introduction

Clinical Spectrum and Epidemiology of Infections Caused by Gram-Negative Bacteria

Clinical Spectrum and Epidemiology of Infections Caused by Gram-Negative Bacteria

Clinical Spectrum and Epidemiology of Infections Caused by Gram-Negative Bacteria

Antimicrobial Drug Resistance in Gram-Negative Bacilli

Antimicrobial Drug Resistance in Gram-Negative Bacilli

Antimicrobial Drug Resistance in Gram-Negative Bacilli

Strain-Typing Methods for Gram-Negative Bacterial Organisms

Strain-Typing Methods for Gram-Negative Bacterial Organisms

Strain-Typing Methods for Gram-Negative Bacterial Organisms

Application of Strain-Typing Methods to Epidemiologic Investigation of Nosocomial Infections Caused by Gram-Negative Bacteria

Application of Strain-Typing Methods to Epidemiologic Investigation of Nosocomial Infections Caused by Gram-Negative Bacteria

Application of Strain-Typing Methods to Epidemiologic Investigation of Nosocomial Infections Caused by Gram-Negative Bacteria

Concluding Remarks

Concluding Remarks

Concluding Remarks

12 Identifying a Pathogen's Biological Determinants of Disease Transmission

12 Identifying a Pathogen's Biological Determinants of Disease Transmission

12 Identifying a Pathogen's Biological Determinants of Disease Transmission

Introduction

Introduction

Introduction

Modes of Disease Transmission

Modes of Disease Transmission

Modes of Disease Transmission

Identifying Genetic Determinants of Disease Transmission

Identifying Genetic Determinants of Disease Transmission

Identifying Genetic Determinants of Disease Transmission

Concluding Remarks

Concluding Remarks

Concluding Remarks

Glossary

Glossary

Glossary

Annotated Websites of Databases Useful for Molecular Epidemiologic Investigations

Annotated Websites of Databases Useful for Molecular Epidemiologic Investigations

Annotated Websites of Databases Useful for Molecular Epidemiologic Investigations

Index

Index

Index