Chapter
2 Genetic Approaches for Signaling Pathway sand Proteins
SENSORY SIGNALING IN BACTERIA
GENETIC ANALYSIS OF SIGNALING PATHWAYS
DOMAIN INTERACTIONS IN SIGNALING PROTEINS
STRUCTURE-FUNCTION STUDIES OF COMMUNICATION MODULES
3 Two-Component Signal Transduction Systems: Structure-Function Relationships and Mechanisms of Catalysis
HISTIDINE PROTEIN KINASES
4 Structural and Functional Conservation in Response Regulators
TWO-COMPONENT SYSTEMS AND THEIR RESPONSE REGULATORS
MOLECULAR STRUCTURE OF CheY: A USER'S GUIDE
STRUCTURAL AND FUNCTIONAL SIGNIFICANCE OF CONSERVED RESIDUES
CONCLUSIONS AND PERSPECTIVES
5 Control of Nitrogen Assimilation by the NRI-NRII Two-Component System of Enteric Bacteria
NITROGEN REGULATION IN THE ABSENCE OF NR,,
STRUCTURE-FUNCTION ANALYSIS OF NRII
PURIFICATION AND CRYSTALLIZATION OF Pn AND RECONSTITUTION OF THE NRII-PII REGULATED PHOSPHATASE
RECONSTITUTION OF THE SENSORY APPARATUS
EVIDENCE THAT THE UTase/UR AND PII ARE REDUNDANT
6 Chemotactic Signal Transduction in Escherichia coli and Salmonella typhimurium
MOTILITY AND EXPRESSION OF THE FLAGELLAR REGULON
CHEMOTACTIC SIGNAL PATHWAY
7 Porin Regulon of Escherichia coli
OTHER FACTORS AFFECTING PORIN EXPRESSION
WHY GO TO ALL THE TROUBLE?
8 Control of Cellular Development in Sporulating Bacteria by the Phosphorelay Two-Component Signal Transduction System
TRANSCRIPTIONAL REGULATION OF THE PHOSPHORELAYCOMPONENTS
SIGNAL INPUT INTO THE PHOSPHORELAY
ENZYMATIC ACTIVITIES OF PHOSPHORELAY PROTEINS
QUATERNARY STRUCTURE OF PHOSPHORELAY COMPONENTS
MODULATION OF PHOSPHATE FLOW BY PHOSPHATASES
KINASE - PHOSPHATASE ANTAGONISM
REPRESSOR - ACTIVATOR ANTAGONISM
III RESPONSE REGULATOR FUNCTIONS
9 Mechanism of Transcriptional Activation by NtrC
EXPERIMENTAL OBSERVATIONS
10 Transcription Regulation by the Bacillus subtilis Response Regulator Spo0A
DNA BINDING SITES FOR Spo0A: 0A BOXES
IN VITRO TRANSCRIPTION REGULATION BY Spo0A
Spo0A AS A MODEL FOR TRANSCRIPTION RESPONSE REGULATORS
COMPONENTS OF THE FLAGELLAR SWITCH
BIOCHEMICAL PROPERTIES OF THE SWITCH PROTEINS
LOCATION OF THE Mot PROTEINS
STOICHIOMETRIC COMPOSITION OF THE MOTOR/SWITCH
ROTOR VERSUS STATOR OF THE MOTOR/SWITCH
FUNCTIONAL ANALYSIS OF THE SWITCH
CheY, CheZ, AND THE SWITCH
OTHER FACTORS AFFECTING SWITCHING
INTERACTION AMONG SWITCHES ON A MULTIFLAGELLATE CELL
12 Signal Transduction and Cross Regulation in the Escherichia coli Phosphate Regulon by PhoR, CreC, and Acetyl Phosphate
SIGNAL TRANSDUCTION PATHWAYS OF THE Pho REGULON
DESCRIPTION OF Pi REPRESSION COMPLEXES
MECHANISMS FOR DETECTION OF ENVIRONMENTAL Pi
MECHANISMS FOR INTERCONVERSION OF PhoRR AND PhoRA
CROSS REGULATION OF THE Pho REGULON
13 Signal Transduction in the Arc System for Control of Operons Encoding Aerobic Respiratory Enzymes
PRIMARY STRUCTURES OFArcB AND ArcA
AUTOPHOSPHORYLATION OF ArcB
PHOSPHORYLATION OF ArcA BY ArcB-P
COMPOUNDS CONTROLLING THE ACTIVITY OF ArcB
CONTROL OF Φ(sdh-lac) EXPRESSION
STUDIES OF OTHER TRANSCRIPTIONAL CONTROLS
WORKING MODEL FOR SIGNAL TRANSMISSION BY THE Arc SYSTEM
14 Dual Sensors and Dual Response Regulators Interact to Control Nitrate- and Nitrite-Responsive Gene Expression in Escherichia coli
DUAL TWO-COMPONENT REGULATORY SYSTEMS
INTERACTIONS BETWEEN THE NarX AND NarL PROTEINS
TARGET OPERON CONTROL REGIONS
15 Regulation of Capsule Synthesis: Modification of the Two-Component Paradigm by an Accessory Unstable Regulator
GENERAL DESCRIPTION OF THE Res REGULATORY NETWORK
END PRODUCT: FUNCTION OF COLANIC ACID CAPSULE
RcsB EFFECTOR IS ESSENTIAL FOR CAPSULE SYNTHESIS
PATHWAY I FOR CAPSULE ACTIVATION: INCREASED PHOSPHORYLATION OF RcsB
PATHWAY H FOR STIMULATION OF RcsB ACTIVITY:RcsA ACCUMULATION
ADDITIONAL LEVELS OF CONTROL: REGULATION OF REGULATOR SYNTHESIS
16 Expression of the Uhp Sugar-Phosphate Transport System of Escherichia coli
SIGNAL TRANSDUCERS: UhpBC
SIGNAL TRANSDUCTION COMPLEX
COMPLEXITY OF SIGNAL TRANSDUCTION
INTRACELLULAR SIGNAL: UhpA
17 Symbiotic Expression of Rhizobium meliloti Nitrogen Fixation Genes Is Regulated by Oxygen
REGULATION OF SYMBIOTIC NITROGEN FIXATION GENES IN R. MELILOTI
FixJ, THE RESPONSE REGULATOR
CONCLUSION AND PERSPECTIVES
18 Complex Phosphate Regulation by Sequential Switches in Bacillus subtilis
ALKALINE PHOSPHATASE GENE FAMILY AS REPORTERS OF THE Pho REGULON
PhoP (RESPONSE REGULATOR) AND PhoR (SENSOR KINASE): THE PRIMARY Pho REGULON SIGNAL TRANSDUCTION SYSTEM
Pho REGULON IS CONTROLLED BY A REGULATORY NETWORK COMPOSED OF THREE TWO-COMPONENT SIGNAL TRANSDUCTION SYSTEMS
DO THE PhoP-PhoR TWO-COMPONENT REGULATORS HAVE A DEVELOPMENTAL SIGNAL TRANSDUCTION ROLE DURING SPORULATION?
ANALYSIS OF PUTATIVE SPORULATION APase (sap) REGULATORY MUTANTS REVEALS NEW INSIGHT INTO REGULATION OF THE phoPR OPERON AND ACTIVATION OF PhoP
19 Two-Component Signal Transduction and Its Role in the Expression of Bacterial Virulence Factors
20 Regulation of Salmonella Virulence by Two-Component Regulatory Systems
BIOLOGY OF SALMONELLA PATHOGENESIS
TWO-COMPONENT SYSTEMS AND THE CONTROL OF SALMONELLA VIRULENCE
ROLE OF THE PhoP/PhoQ SYSTEM IN SALMONELLA PATHOGENESIS
CONCLUSIONS AND PERSPECTIVE
21 Bordetella pertussis BvgAS Virulence Control System
bvg VIRULENCE CONTROL SYSTEM
DOMAIN ORGANIZATION OF BvgA AND BvgS
TRANSCRIPTIONAL REGULATION OF THE bvg OPERON
GENETIC ANALYSIS OF BvgAS
BIOCHEMISTRY OF BvgAS SIGNAL TRANSDUCTION
22 Three-Component Regulatory System Controlling Virulence in Vibrio cholerae
OVERVIEW OF PATHOGENICITY OF VIBRIO CHOLERAE
TRANSMEMBRANE NATURE OF ToxR
TRANSCRIPTIONAL ACTIVATION AS A CONSEQUENCE OF ToxR/ToxS PERIPLASMIC INTERACTION
ANALYZING THE DIMERIZATION MODEL OF ToxR FUNCTION
DNA BINDING BY ToxR AT THE ctx PROMOT ER
ANALYZING THE ToxR DNA BINDING DOMAIN BY MUTAGENESIS
EFFECT OF ToxS ON DNA BINDING BY ToxR
COORDINATE GENE EXPRESSION CONTROLLED BY ToxR AND ToxT
ToxR-DEPENDENT EXPRESSION OF toxT
23 Ti Plasmid and Chromosomally Encoded Two-Component Systems Important in Plant Cell Transformation by Agrobacterium Species
OVERALL FEATURES OF AGROBACTERIUM-MEDIATED PLANT CELL TRANSFORMATION
TWO-COMPONENT REGULATORY SYSTEM ON THE Ti PLASMID: VirA/VirG
SENSING OF PHENOLIC COMPOUNDS
MONOSACCHARIDES IN vir GENE INDUCTION
REGULATION OF chvE EXPRESSION
PREDICTIONS OF THE VirA/VirG-ChvE MODEL
TWO-COMPONENT REGULATORY SYSTEM ON THE CHROMOSOME: ChvG/ChvI
24 Regulation of Glycopeptide Resistance Genes of Enterococcal Transposon Tn1546 by the VanR-VanS Two-Component Regulatory System
SEQUENCE ANALYSIS OF VanR AND VanS
PHOSPHOTRANSFER REACTIONS
IDENTIFICATION OF THE TARGET PROMOTER
PROMOTER ACTIVATION BY VanR
MODULATION BY VanS OF VanR ACTIVITY
25 Tetracycline Regulation of Conjugal Transfer Genes
CONJUGATIVE TRANSPOSONS: A NOVEL TYPE OF INTEGRATEDGENE TRANSFER ELEMENT
TETRACYCLINE-REGULATED ACTIVITIES OF THE BACTEROIDES CONJUGATIVE TRANSPOSONS
TWO-COMPONENT REGULATORY SYSTEM: RteA AND RteB
VI CELLULAR COMMUNICATION AND DEVELOPMENT
26 Switches and Signal Transduction Networks in the Caulobacter crescentus Cell Cycle
CELL DIVISION CYCLE CHECKPOINTS AND THE REGULATION OF DEVELOPMENT
ROLE OF FlbD AS A SWITCH PROTEIN IN FLAGELLAR GENE TRANSCRIPTION
27 The frz Signal Transduction System Controls Multicellular Behavior in Myxococcus xanthus
ISOLATION AND CHARACTERIZATION OF THE frz MUTANTS
frz GENES ARE CHEMOTAXIS GENES IN M. XANTHUS
BIOCHEMICAL ANALYSIS OF THE frz GENE PRODUCTS SHOWS THAT TWO ARE MEMBERS OF THE FAMILY OF TWO-COMPONENT SYSTEMS
THE frz SENSORY SYSTEM IS REQUIRED FOR THE SOCIAL BEHAVIORS OF M. XANTHUS
28 Intercellular Communication in Marine Vibrio Species: Density-Dependent Regulation of the Expression of Bioluminescence
BIOLUMLNESCENT MARINE BACTERIA
DENSITY-DEPENDENT REGULATION OF LIGHT PRODUCTION: AUTOLNDUCTION
REGULATION OF lux EXPRESSION IN V.FISCHERI: QUORUM SENSING
REGULATION IN V.HARVEYI: A MULTICHANNEL SENSOR CIRCUIT
TWO-COMPONENT SIGNAL RELAY
SIGNAL INTEGRATION: THE LuxO PROTEIN
DISCUSSION: SENSORY CHANNELS AND CONNECTIONS
29 A Signal Transduction Network in Bacillus subtilis Includes the DegS/DegU and ComP/ComA Two-Component Systems
TWO-COMPONENT REGULATORY SYSTEMS OF BACILLUS SUBTILIS FORM A SIGNAL TRANSDUCTION NETWORK
DEGRADATIVE ENZYME SYNTHESIS
COMPETENCE GENE EXPRESSION
SIGNAL TRANSDUCTION NETWORK