Chapter
A Look through the Retrospectoscope
Part 1. Retrospective Look at Early Advances
Chapter 1 Molecular Nature, Conjugal Transfer, and Replication of Extrachromosomal Elements, 1961 to 1973
CHOOSING A GRADUATE MENTOR
CHOOSING A POSTDOCTORAL MENTOR
OUT OF SITE, BUT NOT OUT OF MIND, SOME FINAL THOUGHTS FROM AN EARLY GRADUATE STUDENT AND AN EARLY POSTDOC
Chapter 2 R Plasmids and Antibiotic Resistances
H. INFLUENZAE ACQUIRES R PLASMIDS
GONOCOCCI ACQUIRE R PLASMIDS
TOBRAMYCIN RESISTANCE IN A BURN UNIT
A DECADE AND A HALF LATER
Chapter 3 Transposon Tn5, 1973 to 1980
MOLECULAR DISSECTION OF Tn3
Chapter 4 Enterotoxigenic Escherichia coli, 1971 to 1979
CHARACTERIZATION OF ETEC PLASMIDS
Chapter 5 Molecular Epidemiology: Development and Application of Molecular Methods To Solve Infectious Disease Mysteries
Chapter 6 Adherence Mechanisms in Urinary Tract Infections
INVASION OF THE URINARY TRACT
Chapter 7 Escherichia coli Type 1 Pili
ROLE OF TYPE 1 PILI IN INFECTION
GENETICS OF TYPE 1 PILUS EXPRESSION
ROLES OF MINOR PILUS COMPONENTS
A MODEL FOR TYPE 1 PILUS ASSEMBLY
Chapter 8 Mechanisms of Pilus Antigenic Variation in Neisseria gonorrhoeae
PILUS ANTIGENIC VARIATION AND PHASE MUTATION
GENE CONVERSION VERSUS TRANSFORMATION: INSIDE JOB OR EXTERNAL AFFAIR
ANALOGIES IN OTHER PROKARYOTIC SYSTEMS
FACTORS INFLUENCING PILIN GENE RECOMBINATION
Chapter 9 Type 4 Pili in the Families Moraxellaceae and Neisseriaceae
PHENOTYPES OF PILIATED VERSUS NONPILIATED BACTERIA
ROLE OF TYPE 4 PILI IN DISEASE
MOLECULAR GENETICS OF TYPE 4 PILI
Chapter 10 Genes for the Filamentous Hemagglutinin and Fimbriae of Bordetella pertussis: Colocation, Coregulation, and Cooperation?
STRUCTURE OF FHA AND FIMBRIAL PROTEINS
GENE ORGANIZATION AND BIOSYNTHESIS
BEHAVIOR OF MUTANTS IN ANIMAL MODELS
Chapter 11 Early Events in the Pathogenesis of Haemophilus influenzae Disease
H. INFLUENZAE HEMAGGLUTINATING PILI
NONTYPEABLE H. INFLUENZAE HIGH-MOLECULAR-WEIGHT ADHESINS
Chapter 12 Molecular Pathogenesis of Enteropathogenic Escherichia coli
SECRETION OF EPEC PROTEINS
LARGE CHROMOSOMAL REGION ENCODING EPEC VIRULENCE FACTORS
EPITHELIAL CELL RESPONSE TO EPEC INFECTION
THREE-STAGE MODEL OF EPEC PATHOGENESIS
Chapter 13 Murine Colonic Hyperplasia
Part 3. Molecular and Cellular Biology ofIntracellular Bacteria
Chapter 14 Genetic Approaches to Understanding Salmonella Pathogenicity
SCREENING MUTANTS FOR VIRULENCE
IDENTIFICATION OF SALMONELLA-SPECIFIC GENES
ANALYSIS OF SALMONELLA PHENOTYPES THOUGHT TO BE INVOLVED IN VIRULENCE
ANALYSIS OF KNOWN SALMONELLA COMPONENTS AND SYSTEMS FOR THEIR INVOLVEMENT IN VIRULENCE
ANALYSIS OF SALMONELLA GENES ON THE BASIS OF THEIR REGULATION
Chapter 15 Mechanisms of Yersinia Entry into Mammalian Cells
IDENTIFICATION OF GENES REQUIRED FOR ENTRY OF ENTEROPATHOGENIC YERSINIAE INTO EUKARYOTIC CELLS
ROLES OF THE GENES IN THE INFECTION PROCESS
Chapter 16 Cell Biology of Salmonella Pathogenesis
PENETRATION THROUGH POLARIZED EPITHELIAL MONOLAYERS
THE INTRACELLULAR ENVIRONMENT
INTRACELLULAR REPLICATION
Chapter 17 Intracellular Trafficking of Legionella pneumophila within Phagocytic Cells
PATHOGENESIS AND ECOLOGY OF L. PNEUMOPHILA
MATURATION OF THE L. PNEUMOPHILA PHAGOSOME
BACTERIAL FACTORS INVOLVED IN INTRACELLULAR GROWTH OF L. PNEUMOPHILA
L. PNEUMOPHILA FACTORS INDUCED IN RESPONSE TO INTERNALIZATION BY PHAGOCYTES
IMPLICATIONS FOR INTRACELLULAR GROWTH
Chapter 18 Cellular Biology of Listeria monocytogenes Infection
TISSUE CULTURE MODELS OF INFECTION
GENETIC TOOLS IN L. MONOCYTOGENES
BRIDGING THE CELL BIOLOGY AND IMMUNOLOGY OF L. MONOCYTOGENES INFECTION
Chapter 19 Determinants of Chlamydial Pathogenesis and Immunity
DETERMINANTS OF CHLAMYDIAL ADHERENCE TO EUKARYOTIC CELLS
IMMUNITY, IMMUNOPATHOLOGY, AND THE CONTINUING SEARCH FOR A CHLAMYDIA VACCINE
Part 4. Extracellular Structures andProducts
Chapter 20 Genetic Analysis of the Escherichia coli K1 Capsule Gene Cluster
THE POLYSIALIC CAPSULE OF E. COLI K1
BIOSYNTHESIS AND GENETICS OF THE K1 CAPSULE
STRUCTURE AND FUNCTION OF THE KpsMT TRANSPORTER
Chapter 21 Type III Capsular Polysaccharide of Group B Streptococci: Role in Virulence and the Molecular Basis of Capsule Expression
CAPSULAR POLYSACCHARIDES OF GBS
SIALIC ACID IS CRITICAL TO VIRULENCE FUNCTION OF TYPE III CAPSULE
EFFECT OF CAPSULE MUTATIONS ON VIRULENCE IN VIVO
GENETICS OF TYPE III CAPSULE BIOSYNTHESIS
Chapter 22 Unorthodox Secretion by Gram-Negative Bacteria
GRAM-NEGATIVE BACTERIAL CELL STRUCTURE AND FUNCTION
SECRETION OF PERTUSSIS TOXIN
Chapter 23 Holistic Perspective on the Escherichia coli Hemolysin
WHAT IS THE E. COLI HEMOLYSIN?
HOW IS THE HEMOLYSIN TOXIC TO CELLS?
Chapter 24 Yops of the Pathogenic Yersinia spp.
YERSINIA VIRULENCE PLASMIDS
DISCOVERY AND CHARACTERIZATION OF Yops, A HISTORICAL PERSPECTIVE
ROLE OF Yops IN YERSINIA PATHOGENESIS
Chapter 25 Role of Flagella in Campylobacter Pathogenesis
PHASE AND ANTIGENIC VARIATION
ANALYSIS OF FLAGELLIN MUTANTS IN IN VIVO AND IN VITRO MODELS
Chapter 26 Molecular Biology and Role in Disease of the Verotoxins (Shiga-Like Toxins) of Escherichia coli
GENERAL FEATURES OF THE FAMILY
SHIGA TOXIN FAMILY INACTIVATES RIBOSOMES BY AN N-GLYCOSIDASE ACTIVITY
MODELS OF THE N-GLYCOSIDASE REACTION
INTERACTION OF A AND B SUBUNITS
PUTATIVE RECEPTOR-BINDING POCKET OF THE B SUBUNIT
RECEPTOR BINDING OF THE B SUBUNIT
IS Gb3 THE PHYSIOLOGICAL RECEPTOR?
ALTERED BINDING RELATED TO CARBOHYDRATE SPECIFICITY
ROLE OF CERAMIDE IN TOXIN BINDING
HEMOLYTIC UREMIC SYNDROME
Part 5. Virulence Gene Regulation
Chapter 27 Coordinate Regulation of Virulence in Bordetella pertussis Mediated by the vir (bvg) Locus
BEGINNING OF THE MOLECULAR GENETIC ERA AND DISCOVERY OF THE vir (bvg) LOCUS
MECHANISMS OF BvgAS ACTION
cis-ACTING SEQUENCES IMPLICATED IN bvg-RESPONSIVE REGULATION
Chapter 28 Methylation-Dependent and Lrp-Dependent Fimbrial Gene Regulation in Escherichia coli
REGULATION OF FIMBRIA-ADHESIN GENE EXPRESSION
PHASE VARIATION REGULATORY MECHANISMS
Lrp AND DNA METHYLATION CONTROL OTHER FIMBRIAL SWITCHES IN E. COLI AND S. TYPHIMURIUM
Chapter 29 The Tao of Urease
UREASE AS A VIRULENCE FACTOR IN URINARY TRACT INFECTIONS
UREASE AS A FACTOR IN DEVELOPMENT OF CHRONIC GASTRITIS AND PEPTIC ULCERS
OTHER EXAMPLES OF UREASE-PRODUCING PATHOGENS
HETEROMERIC SUBUNIT STRUCTURE OF BACTERIAL UREASES
UREASE GENE CLUSTERS OF THE FAMILY ENTEROBACTERIACEAE
UREASE GENE CLUSTER OF H. PYLORI
UREASE GENES OF GRAM-POSITIVE ORGANISMS
UREA-INDUCIBLE UREASE GENE EXPRESSION: POSITIVE REGULATION BY UreR
NITROGEN-REGULATED UREASE GENE EXPRESSION: POSITIVE REGULATION BY Nac
CONSTITUTIVE EXPRESSION OF UREASE GENES
Chapter 30 pJM1 Plasmid-Mediated Iron Transport-Virulence System of Vibrio anguillarum
BIOSYNTHESIS OF ANGUIBACTIN
REPRESSION BY IRON OF THE EXPRESSION OF THE GENE FOR THE FatA OUTER MEMBRANE PROTEIN, THE RECEPTOR FOR FERRIC ANGUIBACTIN IN V. ANGUILLARUM
POSITIVE REGULATION OF ANGUIBACTIN PRODUCTION IN V. ANGUILLARUM
Part 6. Other Aspects of Bacterial Pathogenesis
Chapter 31 Role of Sucrose Metabolism in the Cariogenicity of the Mutans Streptococci
MECHANISMS OF SUCROSE METABOLISM BY MS
HIGH-AFFINITY SUCROSE-SPECIFIC PTS OF MS
NEW TOOLS AND FUTURE PROSPECTS
Chapter 32 How Many Bacteria Does It Take To CauseDiarrhea and Why?
ENTERIC PATHOGENS CAPABLE OF PRODUCING DISEASE WITH A LOW INFECTIVE DOSE
ENTERIC PATHOGENS THAT REQUIRE A HIGH INFECTIVE DOSE TO PRODUCE DISEASE
ENTERIC PATHOGENS CHARACTERIZED BY AN INTERMEDIATE INFECTIVE DOSE TO PRODUCE DISEASE
DETERMINANTS OF INFECTIVE DOSE: ROLE OF THE GASTRIC BARRIER
GENETIC DETERMINANTS OF ACID RESISTANCE IN SHIGELLA SPECIES
OTHER POTENTIAL DETERMINANTS OF INFECTIVE DOSE
Chapter 33 Genetics as a Route toward Mucosal Vaccine Development
PROPERTIES OF MUCOSAL IMMUNOGENS
MUCOSAL VACCINES BASED ON LIVE ORGANISMS: GENERAL CONSIDERATIONS
LIVE BACTERIAL VACCINES: APPLICATION OF GENETICS
LIVE VACCINES AS CARRIERS OF HETEROLOGOUS ANTIGENS
NONLIVING MUCOSAL ANTIGENS
Chapter 34 Phylogenetic Diversity of Microbial Pathogens
INFERENCE OF ORGANISMAL EVOLUTIONARY RELATIONSHIPS FROM rRNA SEQUENCES
AN APPROACH FOR IDENTIFICATION OF MICROORGANISMS DIRECTLY FROM HOST TISSUE
BACILLARY ANGIOMATOSIS AND THE ALPHA-PROTEOBACTERIA
WHIPPLE'S DISEASE AND THE ACTINOMYCETES
CHARACTERIZATION OF MICROBIAL COMMUNITIES
Molecular Genetics of Bacterial Pathogenesis
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