Description

An overview of the current systems biology-based knowledge and the experimental approaches for deciphering the biological basis of cancer. Cancer is a complex group of diseases with many possible causes. Bringing together the state-of-the-art contributions of international experts, Systems Biology of Cancer proposes an ultimate goal for the whole scientific community: exploiting systems biology to generate in-depth knowledge based on blueprints that are unique to each type of cancer. Cancer is a complex group of diseases with many possible causes. Bringing together the state-of-the-art contributions of international experts, Systems Biology of Cancer proposes an ultimate goal for the whole scientific community: exploiting systems biology to generate in-depth knowledge based on blueprints that are unique to each type of cancer. With over 200 types of cancer diagnosed to date, researchers the world over have been forced to rapidly update their understanding of the biology of cancer. In fact, only the study of the basic cellular processes, and how these are altered in cancer cells, can ultimately provide a background for rational therapies. Bringing together the state-of-the-art contributions of international experts, Systems Biology of Cancer proposes an ultimate research goal for the whole scientific community: exploiting systems biology to generate in-depth knowledge based on blueprints that are unique to each type of cancer. Readers are provided with a realistic view of what is known and what is yet to be uncovered on the aberrations in the fundamental biological processes, deregulation of major signaling networks, alterations in major cancers and the strategies for using the scientific knowledge for effective diagnosis, prognosis and drug discovery to improve public health. Contributors; Preface; Part I. Introduction to Modular Organization of the Networks of Gene Functions and Cancer: 1. Systems biology of cancer progression Sam Thiagalingam; 2. Lessons from cancer genome sequencing Antoine Ho and Jeremy S. Edwards; 3. Application of bioinformatics to analyze the expression of tissue-specific and housekeeping genes in cancer Xijin Ge; Part II. Alterations in the Regulatory Networks of Fundamental Cellular and Molecular Events in Cancer: 4. Events at DNA replication origins and genome stability Kathleen R. Nevis, Kimberly L. Raiford, Cyrus Vaziri and Jeanette Gowen Cook; 5. Systems biology approaches bring new insights in the understanding of global gene regulatory mechanisms and their deregulation in cancer Arnaud Krebs and László Tora; 6. Regulation and dysregulation of protein synthesis in cancer cells Michael J. Clemens, Androulla Elia and Simon J. Morley; Part III. Networks of Events Responsible for the Manifestation of Aberrant Genetic and Epigenetic Codes in Cancer: 7. Genomic instability and carcinogenesis Mark E. Burkard and Prasad V. Jallepalli; 8. Epigenomic code José Ignacio Martín-Subero and Manel Esteller; 9. MicroRNA epigenetic systems and cancer Holly Lewis and Aurora Esquela-Kerscher; 10. Dietary and environmental influences on the genomic and epigenomic codes in cancer Hamid Abdolmaleky and Jin-Rong Zhou; Part IV. Functional Networks of Events that Modulate Phenotypic Manifestation of Cancer: 11. Regulatory signaling networks in cell transformation and cancer Yashaswi Shrestha and William C. Hahn; 12. RAS signaling networks Douglas Faller; 13. The PI3K pathway in cancer Amancio Carnero; 14. TGFβ and BMP signaling in