Melatonin, Sleep and Insomnia ( Endocrinology Research and Clinical Developments )

Publication series :Endocrinology Research and Clinical Developments

Author: Yolanda E. Soriento  

Publisher: Nova Science Publishers, Inc.‎

Publication year: 2016

E-ISBN: 9781611228342

P-ISBN(Paperback): 9781607418597

Subject: L No classification

Keyword: 暂无分类

Language: ENG

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Melatonin, Sleep and Insomnia

Chapter

Chapter II Neuropathology of Insomnia in the Adult: Still an Enigma!

Abstract

Introduction

1. The Biological Clock

2. The Structures Inhibiting Waking Systems

3. The Structures Carrying on Sleep

3.1 Slow Wave Sleep

3.2 REM Sleep

4. The Structures Responsible for Waking State

4.1 The Structures Responsible for “Need for Sleep”

5. General Influences (« Allostatic »)

Discussion and Conclusion

References

Chapter III Non-Pharmacological Alternatives for the Treatment of Insomnia – Instrumental EEG Conditioning, a New Alternative?

1. Abstract

2. Introduction

3. Diagnosis and Classification of Insomnia

4. Pathophysiology of Primary Insomnia

5. Treatment

5.1 Pharmacological Treatment

5.2 Non-Pharmacological Treatment of Insomnia

5.3 Cognitive Behavioral Therapy (CBT)

5.4 Biofeedback

5.5 Instrumental EEG Conditioning (IEC)

5.5.1 Instrumental SMR Conditioning (ISC) and its Impact on Sleep Quality and Declarative Learning

6. Prospects: ISC as Treatment for Primary Insomnia?

References

Chapter IV A Novel Disease Condition Presenting with Insomnia and Hypersomnia Asynchronization

Abstract

1. Introduction

2. Insomnia and Hypersomnia Among Japan Youth

2.1. Recent Statistics of Bedtime and Sleep Duration

2.2. Complaints of Young People with Nocturnal Lifestyle

3. Nocturnal Lifestyles and Behaviors

3.1. Adults and Older Children

3.2. Studies on Preschoolers

4. Nocturnal Lifestyle and Neurological Systems

4.1. Biological Clock

4.2. Melatonergic System

4.3. Serotonergic System

4.4. Reported Disease Conditions Associated with Circadian Disruption

5. Asynchronization

5.1. Presumable Pathophysiology

5.2. Potential Therapeutic Approaches

5.2.1. Basic Principles

5.2.2. Conventional Approaches

5.2.2.1. Light therapy

5.2.2.2. Medications

5.2.2.2.1. Hypnotics

5.2.2.2.2. Antidepressants

5.2.2.2.3. Melatonin and its Agonists

5.2.2.2.4. Vitamin B12

5.2.2.3. Physical activity

5.2.2.4. Chronotherapy

5.2.3. Alternative Approaches

5.2.3.1. Kampo

5.2.3.2. Rhythmic Movements

5.2.3.3. Direct Contact

5.2.3.4. Control of the Autonomic Nervous System

5.2.3.5. Pulse Light

6. Conclusion

Acknowledgment

References

Chapter V Aggression in Older Adult Populations

Abstract

I. Introduction and Background

II. Aggression in Elderly Patients with Medical Conditions

A. Delirium and Toxic States

Management of Delirium

B. Drug-Drug Interactions

III. Aggression in Elderly Patients with Dementia

Management of Behavioral Symptoms of Dementia

IV. Aggression in Elderly Patients with Mood, Anxiety and Primary Psychotic Disorders

Geriatric Mood, Anxiety and Primary Psychotic Disorder: Prevalence and Symptoms

Depression

Bipolar Disorders

Anxiety Disorders

Schizophrenia

Treatment of Elderly Populations with Mood, Anxiety and Primary Psychotic Disorders

Bipolar Disorders

Schizophrenia

Anxiety Disorders

Non-Pharmacological Interventions

V. Future Outlook and Needed Research

VI: Final Commentary

References

Chapter VI The Impact of Cultural Changes on the Relationship between Senior Sleep Disturbance and Body Mass Index among Older Adults in Two Asian Societies

Abstract

Selected Abbreviations ad Acronyms

Introduction

A Strong Contrast of the Elderly Populations Exists Between Two Societies

The Necessity of a Cross-Cultural Evaluation

Materials and Methods

Data

Control Subjects

The Taiwanese Census Data

The Filipinos Census Data

Clinical Research Materials used in this Article for Comparison

The Classification of Obstructive Sleep Apnea Syndrome

Criteria Commonly used in Applying Apnea-Hypopnea-Index (AHI)

Results

Sleeping Apnea in a Taiwanese Sleep Study

Obstructive Sleep Apnea (OSA)

AHI: Decile and the Quartile Distributions

1]. Decile Distributions

2]. Quartile Distribution

A Novel Finding Of AHI: A Quantile-Quantile Plots (Q-Q Plots)

AHI and BMI

The Effect of BMI Grouping on the Frequency of Snoring in a Taiwanese Study

Discussion

Asian OSA Prevalence

Snoring

BMI and Environment

The Comparison of BMI among Three Sleep Studies between Two Societies

The Significance of Marginally Not Significant (P Value = 0.069, Instead Of 0.05) in Measurement (Table 3)

The Importance of Gender Factor

The Importance of Who was Doing Measurement of Height and Weight

The Significance of Asian BMI

Underweight

Underweight and Overweight

Cigarette Smoking

Latent Clinical Factors for the Elderly People

Health Insurance Coverage and its Effect on Sleep Education and Sleep Studies

The Poor Elderly Get Less Sleep

Poverty and Obesity

National Health Insurance

Limitations of Cross-Cultural Sleep Studies

Conclusion

References

Chapter VII A Novel Model Using Generalized Regression Neural Network (GRNN) for Estimating Sleep Apnea Index in the Elderly Suffering from Sleep Disturbance

Abstract

Abbreviations

Introduction

Clinical Subjects and Materials

Nocturnal in-Laboratory Polysomnography

Clinical Classification of Obstructive Sleep Apnea Syndrome

Methods

Results

GRNN Performance

Comparison with the Results of other Regression Models

Comparison with Results of other Studies

Comments on Sensitivity and Specificity

Discussion

The Reason Why We Selected AHI Cut Off of 13 Events per Hours is as Follows

Cost Effectiveness Assessment of our Model

Limitations of Study

Conclusions

References

Chapter VIII Hormones and Insomnia

Abstract

Introduction

Sleep-Endocrine Changes in Patients with Insomnia

Hypothalamo-Pituitary-Adrenocortical (HPA) System

Hypothalamo-Pituitary-Somatotrophic (HPS) System

Gonadal Hormones

Other Peptides

Conclusions

References

Chapter IX Insomnia Among Suicidal Adolescents and Young Adults: A Modifiable Risk Factor of Suicidal Behaviour and A Warning Sign of Suicide?

Abstract

1. Introduction

2. Insomnia and Suicidality Among Adults and Adolescents

2.1. Epidemiological Studies

2.1.1. Insomnia and Impact on Health Among Ordinary Adults and Adolescents

2.1.2. Insomnia Among Suicidal Adults and Adolescents

2.2. Clinical Studies

2.2.1. Insomnia Among Adults: Attempted Suicide and Related Suicidal Phenomena

2.2.2. Insomnia Among Adolescents: Attempted Suicide and Related Suicidal Phenomena

2.2.3. Insomnia Among Suicidal Adolescents: Post Traumatic Stress Disorder (PTSD)

2.2.4. Insomnia Among Adults and Adolescents: Suicide

2.3. Reviews: Adults and Adolescents

3. Conclusion

References

Chapter X Melatonin and Nocturia

Abstract

What is Nocturia?

The Causes of Nocturia in the Elderly

The Causes of Nocturnal Polyuria

The Causes of Diminished Nocturnal Bladder Capacity

Why Nocturia is Troublesome?

Can Melatonin Improve Nocturia?

Melatonin for Treatment of Nocturia

Conclusion

References

Chapter XI Melatonin and Other Sleep-Promoting Melatoninergic Drugs Under the Aspects of Binding Properties and Metabolism

Abstract

Introduction

Binding Sites, Receptor Affinity and Half-Life

Profound Differences in Metabolism and Their Consequences

Versatility Versus Selectivity: Advantage or Disadvantage?

Conclusion

References

Chapter XII Melatonin for Medical Treatment of Childhood Insomnias

Introduction

Physiology and Pathophysiologiy of Melaton in Secretion

Melatonin in the Treatment of Sleep Disorders

Effect Profile and Side Effects

Discussion

References

Chapter XIII Melatonin: Its Significance with Special Reference to Sedation and Anesthesia

Abstract

1. Introduction

2. Effect of Melatonin on Anesthesia

2a. Relief of Preoperative Stress - Premedication

2b. Melatonin and General Anesthesia

2c. Effect of Melatonin on Postoperative Outcome

3. Effect of Anesthesia and Traditional Sedative Techniques on Melatonin

4. Conclusion

References

Chapter XIV Sleep Disturbance in Obsessive-Compulsive Disorder

Abstract

Introduction

Methods

Subjects

Diagnostic and Symptomatological Evaluation

Statistical Analysis

Results

Conclusion

References

Chapter XV Effects of Sunbathing on Insomnia, Behavioural Disturbance and Serum Melatonin Level

Abstract

Introduction

Case

Clinical History

Treatment Schedule

Results

Serum Levels of Melatonin and Cortisol

Effect of Sunbathing

Effects of Melatonin on Insomnia and Behavioural Disturbance

Mental Retardation

The Elderly and Persons with Dementia

Conclusions

References

Chapter XVI Neuroimaging Insights into Insomnia

Abstract

1. Introduction

2. Structural and Functional Imaging in Insomnia

3. Functional Imaging of Hypnotic Drugs Response in Healthy Individuals

4. Daytime Functioning Impairments

5. Hyperarousal Hypothesis in Insomnia

5.1. Insomnia and Hyperarousal

5.2. Locus Coeruleus and Arousal

6. Insomnia and Depression

6.1. Hyperarousal Hypothesis in Depression

7. Neuroimaging of Sleep in Depression

8. Summary

Acknowledgments

References

Chapter XVII Neuroimaging Insights into the Dreaming Brain

Abstract

Introduction

Modern History of Dream Research

Functions of Dreaming

Neuroimaging View in REM Sleep Physiology

Distribution of Brain Activity during REM Sleep

Transient Activations during REM Sleep

Integration of Brain Mapping with Dreaming Data

Dream, REM Sleep and Psychiatric Illnesses

Conclusions

Acknowledgments

References

Index

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