Chapter
One - Dental and craniofacial reconstructions using biomaterials
1 - Clinical presentation: reconstruction using composite materials
1.1 Historical overview of composite resins and resin components in dentistry
1.2 Bonding substrates: enamel and dentin
1.3 Clinical performance of resin restorations
1.5 Tooth preparation, form, and function
1.6 Restoration placement techniques
1.7 Clinical challenges and composite restoration failures
1.8 Effects of function, fatigue, and degradation
2 - Reconstructions using alloys and ceramics
2.2 Overview of materials used in prosthetic restorations
2.2.1.1 Nickel–chromium (Ni-Cr)
2.2.1.2 Cobalt–chromium (Cr-Co)
2.2.2.1 Gold-platinum-palladium (Au-Pt-Pd)
2.2.2.2 Gold-palladium-silver (Au-Pd-Ag)
2.2.2.3 Gold-palladium (Au-Pd)
2.2.2.4 Silver-palladium (Ag-Pd)
2.2.3.2 Feldspathic with lithium disilicate
2.2.3.3 Aluminized ceramics
2.2.3.5 Yttria-stabilized zirconia
2.2.4.3 Resin-modified glass ionomer
2.3 Clinical indications: philosophical context
2.3.2 Metal and ceramic indirect restorations
2.4 Implant-supported restorations
2.4.1 Implant indications: complete edentulous patients
2.4.2 Partially edentulous patients
2.4.6 Implant maintenance
2.5 Dental preparation, adaptation, and cementation of indirect restorations
2.6 Shape and function of indirect restorations
2.6.2 Implant-supported prosthesis
2.6.2.1 Biomechanical considerations
2.6.2.2 Immediate versus late loading
2.6.2.3 Cemented prosthesis versus screwed prostheses
2.6.2.4 Advantages and disadvantages: passive adaptation
2.7 Clinical challenges and failures
2.7.1 Clinical challenges in dental prosthesis
2.7.2 Selecting materials and techniques
2.7.3 Marginal adaptation
2.7.4 Load to fracture, hardness, soft tissue relationships, biocompatibility
3 - Interfaces in fixed dental prostheses: challenges and opportunities
3.2.1 Fabrication of surface glass-infiltrated zirconia
3.2.2 Determination of the veneer/core interfacial fracture resistance
3.2.3 Determination of the zirconia–resin interfacial fracture resistance
3.2.4 Statistical analysis
3.3.1 The veneer/core interface
3.3.1.1 Porcelain-veneered zirconia
3.3.1.2 Glass-infiltrated zirconia
3.3.2 The ceramic/cement interface
3.4.1 Fracture resistance of veneer/core diffusion bonding
3.4.2 Fracture resistance of ceramic/resin adhesive bonding
Two - Fundamental structure/property characteristics
4 - Fundamentals of the material-tissue interface in dental reconstructions: structure/property relationships and characterization
4.1 Human teeth and the dentinoenamel junction
4.1.1 Dentinoenamel junction: mechanical properties
4.1.2 Dentinoenamel junction: morphologic characteristics
4.2 Materials and systems: natural versus synthetic
4.3 Interfacial engineering and composite restorations
4.3.1 Restorative dentistry: composites and adhesives
4.4 In situ structure/property characterization of the adhesive/dentin interface
4.5.1 Raman and adhesive/dentin interface characterization
4.6 Scanning acoustic microscopy
4.6.1 Scanning acoustic microscopy and adhesive/dentin interface characterization
4.7 Fourier transform infrared chemical imaging
4.7.1 Fourier transform infrared imaging and adhesive/dentin interface characterization
5 - Understanding the mechanical behavior of the material–tissue and material–material interface in dental reconstructions
5.2 The material–tooth interface
5.2.1 The interface of resin and adhesive with dentin and enamel
5.2.2 Interfacial testing methods
5.2.2.1 Tensile and shear
5.2.2.3 Fracture mechanics
5.3 The resin–ceramic interface—cementation
5.3.1 Resin strengthening of predominantly glassy ceramics
5.3.2 Resin cementation of zirconia polycrystalline ceramics
5.3.3 Adhesion test methods for the resin cement–ceramic interface
5.4 Sintered and soldered joints–bilayer interfaces in dentistry
5.4.1 Internal residual stresses
5.4.2 The zirconia–veneer interface
5.4.3 Mechanical properties of bilayer interfaces
5.4.4 Clinical findings on veneered zirconia restorations
5.4.5 Measurement of residual stresses
5.4.6 Future perspectives
6 - Understanding the chemistry and improving the durability of dental resin–dentin bonded interface
6.2 Mechanisms of dentin–resin bonding
6.3 Factors that compromise the durability of dentin–resin bond
6.4 Strategies to improve the dentin–resin bond durability
6.4.1 Modification of hybrid layer with antibacterial bonding system
6.4.1.1 Antibacterial effects
6.4.1.2 The antibacterial mechanism of quaternary ammonium methacrylates
6.4.1.3 Cytotoxicity of quaternary ammonium methacrylates
6.4.1.4 Nanoparticles for antibacterial activity
6.4.2 Improvement of esterase resistance and infiltration of adhesive
6.4.2.1 Development of water-compatible, esterase-resistant adhesives
6.4.2.2 Ethanol-wet bonding technique
6.4.3 Endogenous protease inhibition and collagen biomineralization
6.4.3.1 Inhibition of endogenous proteases
6.4.3.2 Protein cross-linker agents
6.4.3.3 Biomineralization of nude collagen fibrils
7 - Biology of the oral environment and its impact on the stability of dental and craniofacial reconstructions
7.2 Overview of salivary proteins
7.5 Biofilm–bacteria interaction
7.5.1 Influence on the stability of dental and craniofacial reconstructions
7.6 Biofilm and dental devices
7.7 Introduction to factors known to impact salivary protein–bacteria interactions with reconstructions
Three - Characterization of material-tissue interfaces in dental and craniofacial reconstructions
8 - Morphologic and structural analysis of material-tissue interfaces relevant to dental reconstruction
8.2 Structure of enamel and effect on adhesive bonding
8.3 Structure of dentin and effect on adhesive bonding
8.4 Generations of dentin adhesives
8.5 Bonding to cavity walls
8.5.1 Dentin tubule orientation
8.5.2 Regional bond strength to cavity walls
8.7 Regional bond strength differences in dentin
9 - Analyses of material-tissue interfaces by Fourier transform infrared, Raman spectroscopy, and chemometrics
9.1 Brief introduction to vibrational spectroscopic techniques
9.1.1 Infrared spectroscopy
9.2 Case study 1: in situ monitoring of photopolymerization kinetics using ATR/FTIR spectroscopy
9.3 Case study 2: evaluation of the adhesive/dentin interface under aging using Raman microscopy
9.4 Case study 3: compare and contrast FTIR and Raman imaging analysis
9.4.1 Raman microspectroscopic imaging
9.5 Case study 4: multivariate analysis of spectroscopic data to confirm phase partitioning in methacrylate-based dentin adhesiv...
10 - Material-tissue interfacial phenomena: challenges in mathematical modeling
10.2 Macro- and microscale stress analysis of d-a interface
10.2.1 Macroscale behavior
10.2.2 Microscale behavior
10.3 Rate-dependent microscale stress analysis of d-a interface
Four - Lessons learned: next generation reconstructionsand future opportunities
11 - Dentinoenamel junction: motif for interfacial mechanics of dissimilar materials
11.2 DEJ literature review
11.2.1 Mechanical properties: indentation and fracture
11.2.2 Morphology and composition
11.3 Homotopic experimental characterization of DEJ
11.3.1 Sample preparation
11.4 FE modeling of the DEJ region
11.5 Discussion and conclusion
12 - Chimeric biomolecules: biomolecular recognition–based self-organization at the bio-material interfaces
12.2 Controlled hierarchical interface of mineralized hard tissues
12.3 Functional integration of titanium-based implant materials
12.4 Osteointegration of biofunctionalized implant materials
12.5 Solid-binding peptides as molecular building blocks to control specific interactions at the materials interfaces
12.6 Biofunctionalization of titanium dental implants materials using solid-binding peptides
12.7 Self-organized chimeric peptides toward creating controllable biomaterial interfaces
12.8 Calcium phosphate coating of titanium implants to increase biocompatibility
12.9 Peptides to tune calcium phosphate recognition and mineralization
12.10 Chimeric genetically fused protein as a modular biomolecular device at the interface: from monitoring to biomolecular medi...
13 - Stem cells and dental tissue reconstruction
13.2.1 Key properties of stem cells
13.2.2 Embryonic, induced pluripotent, and multipotent stem cells
13.2.2.1 Human embryonic stem cells
13.2.2.2 Induced pluripotent stem cells
13.2.2.3 Multipotent stem cells
13.2.3 Stem cells in pulp and apical papilla
13.2.3.1 Dental pulp stem cells
13.2.3.2 Stem cells from apical papilla
13.2.3.3 Stem cells from human exfoliated deciduous teeth
13.2.4 Stem cells in periodontal ligament
13.2.4.1 Periodontal ligament stem cells
13.2.5 Stem cells in dental follicle
13.2.5.1 Dental follicle stem/precursor cells
13.2.5.2 Periapical follicle stem cells
13.2.6 Stem cells in inflamed dental tissues
13.2.6.1 Dental pulp stem cells from inflamed pulp
13.2.6.2 Periodontal ligament stem cells from inflamed periodontal ligament
13.2.6.3 Inflamed periapical progenitor cells
13.3 Dental tissue regeneration
13.3.1 Dentin-pulp regeneration
13.3.2 Periodontal tissue regeneration
13.3.3 Whole tooth regeneration
13.3.3.1 Tooth regeneration using tooth germ cells
13.3.3.2 Bioroot engineering
13.3.3.3 Regeneration of root by dental follicle stem cells
13.4 Conclusions and prospects