Chapter
1.4. Emergence of materiomics
1.5 Conclusion and book outline
2 Physico-chemical material properties and analysis techniques relevant in high-throughput biomaterials research
2.1 Basic principles: physical and chemical properties of polymeric biomaterials
2.1.1 Bulk characteristics
2.1.2 Surface characteristics
Surface chemistry has an important effect on cell behaviour
2.2 Relation to materiomics: techniques that allow high-throughput material characterization
2.2.1 Bulk characterization in high throughput
High-throughput bulk analysis of chemical properties
Fourier transform infrared (FTIR)/Raman spectroscopy
High-throughput bulk analysis of mechanical properties
2.2.2 Surface characterization in high throughput
High-throughput surface analysis of chemical properties
X-ray photoelectron spectroscopy
Time-of-flight secondary ion mass spectrometry
High-throughput surface analysis of physical properties
3 Materiomics using synthetic materials: metals, cements, covalent polymers and supramolecular systems
3.2 Basic principles of different synthetic materials
3.2.2 Synthetic covalent polymers
3.2.3 Supramolecular chemistry and (bio)materials
3.3 Materiomics using synthetic materials
3.3.1 Screening of metals and cements
3.3.2 Arrays of synthetic covalent polymers
Variations in monomer composition
Tyrosine-derived polymers
3.3.3 Screening of supramolecular biomaterials
Examples of supramolecular systems
Perspective on supramolecular chemistry in materiomics
4 Microfabrication techniques in materiomics
4.1 Basic principles of microfabrication
4.1.2 Materiomics and µTAS
4.1.3 Microfabrication techniques and processes
Exposure and post-exposure treatment
Development, descumming and post-baking
Direct writing techniques
Electron beam, focused ion beam and laser-based techniques
Techniques based on atomic force microscopy
Polymer micromoulding techniques
4.2 The application of microfabrication in materiomics
4.2.1 Microfabrication as tool in high-throughput screening of material libraries
4.2.2 Microfabrication techniques for scaffold fabrication
5.1 Basic principles of assay development
5.2 Relation to materiomics
6.1 Origins of high-content imaging
6.2 High-content imaging techniques
6.3 The image analysis pipeline
6.5 High-content imaging in materiomics
7 Computational analysis of high-throughput material screens
7.1 Basic principles of data analysis
7.1.1 Statistical inference: y
Testing for material effects
Material ranking and selection
Multiple material performances
Exploring material responses
7.1.2 Model learning: f(x)
Role of material descriptors
7.1.3 Experimental design: x
Sequential designs and optimization algorithms
Exchange of experimental results
7.2 Computational analysis in materiomics research
7.2.1 Spectroscopy descriptors: descriptor reduction and interpretation
7.2.2 Molecular descriptors: towards hybrid surrogate-theoretical models
7.2.3 Morphological descriptors: describing the local cell environment
7.2.4 Describing dynamic behaviour
8 Upscaling of high-throughput material platforms in two and three dimensions
8.1 Basic upscaling principles
8.1.1 Basic processes for the generation of chemical libraries
8.1.2 Basic processes for the generation of micro- and nanotopographical patterns
8.1.3 Translation to three dimensions
8.2 Upscaling and materiomics
8.2.1 Upscaling of chemical libraries
8.2.2 Upscaling of topographical libraries
8.2.3 Translation to three-dimensional constructs
9 Development of materials for regenerative medicine: from clinical need to clinical application
9.1 Basic principles: development of materials for regenerative medicine
9.1.1 The changing role of materials in medicine
9.1.2 Classic approach to materials development
Material choice and implant design
Biological assessment of biomaterials
From R&D results to clinical application
9.2 Relation to materiomics: from high-throughput screening to large animal studies and beyond
9.2.1 Application of high-throughput combinatorial polyurethane libraries for isolation of MSCs
9.2.2 Application of high-throughput polymer blend libraries for augmentation of MSC growth and differentiation
9.2.3 Identification, fabrication and testing of candidate polymers for large animal studies
9.2.4 Identification of the appropriate large animal model
9.2.5 Experimental and surgical technique using the candidate polymer
10 Non-biomedical applications of materiomics
10.1 Tutorial on basic principles
10.1.1 Materials complexity
10.1.2 Materials properties
Microstructure and phase behaviour
Electronic and optical properties
Transport, sorption and adsorption properties
10.1.3 Combinatorial synthesis and high-throughput methods
10.2 Relation to materiomics
10.2.1 Library preparation
10.2.2 Electronic and electrochemical properties
10.2.3 Mechanical properties
10.2.4 Spectroscopic properties
10.2.5 Transport and adsorption properties
10.2.6 Informatic approaches
Materiomics
：High-Throughput Screening of Biomaterial Properties
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