Research Ethics :A Philosophical Guide to the Responsible Conduct of Research

Publication subTitle :A Philosophical Guide to the Responsible Conduct of Research

Author: Gary Comstock  

Publisher: Cambridge University Press‎

Publication year: 2013

E-ISBN: 9781139602679

P-ISBN(Paperback): 9780521187084

Subject: R Medicine and Health

Keyword: 医药、卫生

Language: ENG

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Research Ethics

Description

Education in the responsible conduct of research typically takes the form of online instructions about rules, regulations, and policies. Research Ethics takes a novel approach and emphasizes the art of philosophical decision-making. Part A introduces egoism and explains that it is in the individual's own interest to avoid misconduct, fabrication of data, plagiarism and bias. Part B explains contractualism and covers issues of authorship, peer review and responsible use of statistics. Part C introduces moral rights as the basis of informed consent, the use of humans in research, mentoring, intellectual property and conflicts of interests. Part D uses two-level utilitarianism to explore the possibilities and limits of the experimental use of animals, duties to the environment and future generations, and the social responsibilities of researchers. This book brings a fresh perspective to research ethics and will engage the moral imaginations of graduate students in all disciplines.

Chapter

The plan of this book is to introduce the RCR topics organized as an expanding moral circle

Bibliography

Part A Protect my interests

Graduate students have diverse interests

yet all have a common set of duties

including the duty to avoid research misconduct

Case study: "Can of worms," by John Allen5

Chasing phantoms

Trying to do good

Heroes

and to blow the whistle

But is whistle-blowing really in an egoist' s interests?

Kinds of interests

Rational egoism is the view that one should always act to best satisfy one´s categorical interests

How to proceed as an egoist

Bibliography

Chapter 1 Report misconduct

What is cheating?

1. An act of rule-breaking

2. With the intention not to be caught

3. In a context in which permission to break the rule has not been granted

Is cheating unethical for egoists?

No: egoists have reasons to cheat

Yes: egoists have stronger reasons not to cheat

because they have their own internal filters

and are surrounded by cheater detectors

cheater detectors who disapprove of cheaters

and punish cheaters

and, furthermore, the community requires whistle-blowing

So, in situations of confusion and ambiguity, honesty seems the best policy - even for egoists

1. Excellent researchers are not necessarily ethical researchers

2. Everyone is not doing it

3. Faculty and administrators can do something about it

4. And students can do something about it

Bibliography

Chapter 2 Avoid plagiarism

Protect myself against charges of plagiarism

Can I get away with it?

Key

Why words matter to the egoist

Conclusion

Bibliography

Chapter 3 Beware intuition

Egoists must be conscious of observation bias

wary of misleading heuristics

and on guard against self-misunderstanding

not to mention probability ineptness

To safeguard judgments against prejudice and intuition, engage others

Bibliography

Chapter 4 Justify decisions

Give reasons to justify your decisions

especially in borderline cases

Blots and gels

Gross misrepresentation

More subtle manipulations

Brightness/contrast adjustments

Cleaning up background

Splicing lanes together

Micrographs

Enhancing a specific feature

Linear vs. nonlinear adjustments

Misrepresentation of a microscope field

Resolution

Other data-management issues

Conclusion

Conclusion: some reservations about egoism

Bibliography

Part B Promote our interests

Graduate students sign diverse contracts

Yet all are part of one contractual community

in which giving reasons comes naturally

because we are emotional, social animals

and yet the community is constantly threatened by unreasonable decisions

Reason-giving contractualism is the view that a person should always act in accord with principles that no free and equal person could reasonably reject

How to proceed as a contractualist

Bibliography

Chapter 5 Articulate reasons

Professional codes articulate two types of rules

Common rules that members should internalize

Specific rules that members should examine critically

and be able to justify

Specifying the contents of a code

The Code of Ethics of the ESA

Conclusion

Conclusion

Bibliography

Chapter 6 Write cooperatively

Authorship is complicated

Acknowledging coauthors

Guidelines: "Publication ethics: a common sense guide," by Wesley E. Snyder7

References for Wilson, Balaban and Comstock

Chapter 7 Protect manuscripts

A peer reviewer is an implicit contractor

1. Role of the peer review system

2. Problems with the peer review system

2.1. Nonperformance of editors and reviewers

2.2. Conflicts of interest of reviewers

2.3. Inadequate recognition and encouragement of innovation

2.4. Publication bias

2.5. Variability of reviewers: assassins, demoters, pushovers, and zealots

3. Guidelines for peer review

3.1. Archival journal articles

4.2. Grant proposals

5. Carrots and sticks in the peer review system

6. Conclusions

References for Wilson

How to proceed as a peer reviewer

Chapter 8 Clarify statistics

Collect data responsibly

and guard its confidentiality

Case study: "What educated citizens should know about statistics and probability," by Jessica Utts1

1. Cause and effect

2. Statistical significance and practical importance

3. Low power versus no effect

4. Biases in surveys

5. Probable coincidences

6. Confusion of the inverse

7. Average versus normal

Conclusion: some reservations about contractualism

Bibliography

Part C Respect strangers’ rights

Graduate students have various legal rights

Yet all have the same moral rights

Moral rights theories are views that hold that one should always respect the dignity of others

Case study: human pesticide toxicity testing

Bibliography

Chapter 9 Inform subjects

Introduction

What informed consent is

Why it' s complicated

Why it' s hard to get

Why it matters

Background essay: "Informed consent and the construction of values," by Douglas MacLean 2

The value of consent in promoting well-being and in promoting freedom

Informed consent in the physician-patient relationship

A challenge to the assumption of existing preferences

Framing effects and methods for eliciting preferences

How to get experimental subjects' informed consent: sample form

Bibliography

Chapter 10 Mentor inclusively

A mentor is a counselor

Background essay: "Mentoring," by Ellen Hyman-Browne (Deceased), Michael Kalichman and Daniel Vasgird1

I. Mentoring and its importance in the education and training of science professionals

II. Description of mentoring: the complexity of the role and the many forms it takes

III. Roles, activities, and functions

IV. Mentoring on ethics and responsible conduct of research

V. The ethics of mentoring

VI. The responsibility to mentor minorities and women

VII. Responsibilities of trainees

1. Identify career plans

2. Locate prospective mentors

3. Distinguish between supervisors and mentors

4. Be clear about needs and expectations

5. Keep learning about effective mentoring

VIII. Responsibilities of mentors

1. Be available

2. Allow for differences in personalities

3. Let trainees make their own decisions

4. Teach by words and example

5. Keep learning about effective mentoring

IX. Dealing with problems in the mentor-trainee relationship

X. Award/rewards

Exercise: "Interview your mentor," by Gary Comstock and Charlotte Bronson3

A. Authorship practices

B. Intellectual property

C. Education in research ethics

D. Progress to degree

Case study: "Why 'female' science professor?" by Female Science Professor 4

Case study: "NIH uncovers racial disparity in grant awards," by Jocelyn Kaiser 5

Conclusion

Chapter 11 Recognize property

Introduction

Who owns your data?

Background essay: "Intellectual property," by Adam Cureton, Douglas MacLean, Jami Taylor and Henry Schaffer 1

Introduction: property rights

Types of intellectual property

Types of intellectual property law

1. Copyright

2. Patents

3. Trademarks

4. Trade secrets

Violations of intellectual property law

The justification of intellectual property rights

Summary

Case study: "DNA patents and human dignity," by David B. Resnik 22

Do DNA patents violate human dignity?

DNA patents and slavery

DNA patents and commodification

Do DNA patents threaten human dignity?

Conclusion

Acknowledgments

Conclusion

Bibliography

Chapter 12 Reveal conflicts

Introduction

Background essay: "Shared responsibility, individual integrity: scientists addressing conflicts of interest in biomedical research," Federation of American Societies for Experimental Biology 2

Scope and types of academia-industry relationships in science

Benefits of academia-industry relationships

Challenges of academia-industry relationships and conflicts of interest

Ongoing challenges for academic investigators

Challenges and guiding principles: how do investigators protect against research bias in industry relationships?

Guiding principles

Conclusion

Conclusion: some reservations about rights

Bibliography

Part D Honor all interests

Research aims at a variety of good consequences

Naive utilitarianism requires maximizing good consequences

while assigning all like interests an equal weight

But not all good consequences are acceptable

Two-level utilitarianism is the view that one should habitually act to respect rights but when thinking critically should maximize good consequences

including good consequences for sentient animals

Conclusion: how to proceed as a utilitarian

Bibliography

Chapter 13 Treat humanely

Everyday rules for treating animals humanely in research

Critical thinking about using animals in research

Policy:

Background essay: "The case for the use of animals in biomedical research," by Carl Cohen2

Why animals have no rights

In defense of "speciesism"

Concluding remarks

Substitution

Reduction

Consistency

Background essay: "Util-izing animals" by Hugh LaFollette and Niall Shanks (Deceased)3

The moral worth of animals

Three moral asymmetries

a) Acts vrs. omissions

b) Definite harms vrs. possible benefits

c) The creatures which suffer vrs. the creatures which benefit

Consequences of rejecting these asymmetries

What really goes on the scales?

Difficulties of calculation

Conclusion

Conclusion

Bibliography

Chapter 14 Preserve environments

Ecosystems have utility for future people and animals

Background essay: "The ethics of climate change", by John Broome1

Ethics of costs and benefits

The richer future

Temporal distance

Market discount rates?

Conclusion

Bibliography

Chapter 15 Cultivate responsibility

Background essay: "Wingspread declaration on renewing the civic mission of the American research university," by Harry Boyte and Elizabeth Hollander1

The civic responsibilities of research universities2

The challenge

Making democracy come alive

Conclusion: some reservations about two-level utilitarianism

Bibliography

Conclusion

Bibliography

Index

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