Contents

Preface

Chapter 1

Structural Basis of Protein Kinase C and the Interactions with Modulators

Abstract

Introduction

Structure Analysis of PKC( C1B Protein

MD Simulations Revealed Distinct Characteristics between the Free Protein and the Activator-Binding Complexes

Root Mean-Square Fluctuations (RMSF) of Protein Backbone Atoms Revealed Intriguing Modes of Binding

Hydrogen Bonding Networks in the PKC(-Activator Complexes

The Validity of the H-Bond Formations within the PKC(-Bryostatin Complex

The Role of Trp252 in the Activator Binding

Conclusion

Acknowledgments

References

Chapter 2

Protein Kinase Cα as a Therapeutic Target in Cancer

Abstract

1. Introduction

2. Structure of PKCα and Substrates for PKCα

3. PKCα and Cancer Cell Survival and Proliferation

4. PKCα and Cancer Cell Apoptosis

5. PKCα and Cancer Cell Migration and Invasion

6. PKCα and Multidrug Resistance (MDR)

7. PKCα-Targeted Therapeutic Molecules

Conclusion

Acknowledgments

References

Chapter 3

Tumor Suppressive Functions of Protein Kinase C( in DNA Damage Response

Abstract

Introduction

Feature of PKC(

PKC( Regulation of p53

Control at the Transcription

Control at the Post-Translation

PKC( Regulation on the Upstream of p53

Transcriptional Regulation of PKC( by p53

Future Perspective

Acknowledgments

References

Bibliography

Related Nova Publications

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Index

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