Chapter
b. New Types of Long Strictureplasties
c. Strictureplasty vs. Resection
d. Surgery for Diffuse Jejunoileal Disease
3. Ileocolonic and Ileal Diseases
c. Surgery for Anastomotic Recurrence
c. Total Colectomy and Procotocolectomy
Factors Affecting Postoperative Recurrence
2. Disease Duration before Surgery
3. Indications for Surgery
Prevention of Postoperative Recurrence
2. Prophylactic Medications
Evidence-Based Recommendation
Practical Strategy for Prevention of Recurrence
Chapter 2 Dendritic Cells and Intestinal Epithelial Permeability in Crohn´s Disease
The Concept of DC Maturation
DC Origin and Subsets in Human and Rodents
The Intestinal Epithelial Barrier
Intestinal Barrier Dysfunction in CD
DCs and the Intestinal Epithelial Barrier in CD
Chapter 3 Monitoring Crohn´s Disease (CD)
Hospital Standardization of Clinical Procedures
History of Scales of Clinical Use in CD
Crohn´s Disease Activity Index
Inflammatory Bowel Disease Questionnaire
The Beck Depression Inventory
Standardization of Monitoring Procedures in CD
Factor Analyses of Components Included in Combined Scales Used in CD
Investigation of Components of Error Sources in Establishing Summary Scores
Error Estimation in the Rating of Disease Status
Technical Noise and Errors in Inclusion Rating of Disease Status
Chapter 4 Surgical Intervention for Small Bowel Crohn’s Disease
Pre-Operative Assessment of the Extent of Disease
Radiological Investigations
Intra-Abdominal Abscesses
Failed Medical Therapy / Intractability
Laparoscopic Versus Open Surgery
Principles of Operative Management of CD
Intra-Operative Assessment of Disease
Intra-Operative Decision-Making
Surgical Options [Resection, Strictureplasty, Bypass or Stoma]
Stapled Versus Hand-Sewn Anastomosis
Anastomotic Configuration
Intraoperative Difficulties
Factors Influencing Recurrence
Post Operative Advice / Prophylaxis
Chapter 5 A Rasch Model of the Crohn’s Disease Activity Index (CDAI): Equivalent Levels of Ranked Attribute and Continuous Variable Scales
Crohn’s Disease Activity Index
Partial Credit Rasch Model of the CDAI
Nature of Variable Scales
Attributes of Variable Data Relationships
Origin-Shifted Logarithmic Relationship
Criteria for Equivalency of Variable Scales
Three-Percentile Regression
Proportional-Error Deming Regression
Results: Relation of Rasch Logits to Other CDAI Variables
Ranked Attribute Variables Treated as If Each Attribute Is Continuous and One Unit Wide
Continuous Scale Variables
Chart of CDAI Variable Equivalencies
Traditional vs. CDAI Rasch Models
Appropriateness of Methods Developed Here for Studying Equivalency of Variable Scales
Should Equal Interval Rasch Logits Be Used in Place of CDAI?
Chapter 6 The Utility of Serological Markers in Inflammatory Bowel Diseases: Gadget or Magic?
Serologic Panel for Inflammatory Bowel Disease (IBD)
Anti-Neutrophil Cytoplasmic Antibody (ANCA)
Anti–Saccharomyces Cerevisiae Antibodies (ASCA)
Newly Discovered Serologic Markers
The Diagnostic Value of the Serologic Markers in IBD
Association with Disease Phenotypes and Progression
Serologic Markers in the Follow-Up and Treatment of IBD
Mutations of the Serologic Markers and Receptors Taking Part in Innate Immunity
Chapter 7 Genetics of Crohn’s Disease
Mediterranean Fever Gene (MEVF)
Chapter 8 Recombinant Human Growth Hormone Treatment in Patients with Growth Deficiency and Crohn’s Disease: New Perspectives
I. Growth Disturbances in CD
II. Inflammatory Process and Growth
a) Cytokines and the Somatotropic Axis
b) Cytokines and Growth Plate
III. Chronic Malnutrition and Growth
IV. Glucocorticoids and Growth
V. Anti-Inflammatory Therapy and Growth
VIII. Combined Treatment with rhIGF-I+rhIGFBP3 and rhGH+rhIGFBP3
Crohn's Disease: Etiology, Pathogenesis and Interventions
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