Advances in Radiation Therapy ( Progress in Tumor Research )

Publication series : Progress in Tumor Research

Author: Guckenberger M.; Combs S.E.; Zips D.  

Publisher: S. Karger AG‎

Publication year: 2018

E-ISBN: 9783318063622

P-ISBN(Paperback): 9783318063615

Subject: R730.55 radiotherapy

Keyword: 放射医学,肿瘤学

Language: ENG

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Description

Developments in radiation oncology have been key to the tremendous progress made in the field in recent years. The combination of optimal systemic treatment and local therapy has resulted in continuing improved outcomes of cancer therapy. This progress forms the basis for current pre-clinical and clinical research which will strengthen the position of radiation oncology as an essential component of oncological care. This book summarizes recent advances in radiotherapy research and clinical patient care. Topics include radiobiology, radiotherapy technology, and particle therapy. Chapters cover a summary and analysis of recent developments in the search for biomarkers for precision radiotherapy, novel imaging possibilities and treatment planning, and advances in understanding the differences between photon and particle radiotherapy. Advances in Radiation Therapy is an invaluable source of information for scientists and clinicians working in the field of radiation oncology. It is also a relevant resource for those interested in the broad topic of radiotherapy in general.

Chapter

Preface

References

Principles and Developments in Cancer Immunotherapy and Approaches for Combination with Tumour Irradiation

Abstract

Historical Overview of Immunotherapy Development

Cancer Immunotherapy Concepts

Immunological Effects of Radiation, Rationale for Combination Therapies

Combination Concepts

Combination of Radiotherapy and Immunotherapy in the Clinic

Conclusion

References

Imageable Biomarkers for Radiotherapy Response

Abstract

PET Imaging

Imageable Biomarkers

Imaging of Proliferation

The Future of Biomarker Imaging for Radiotherapy

References

Targeting Tumor Microenvironment and Metabolism to Overcome Radiation Resistance

Abstract

Role of the Tumor Microenvironment

Tumor Microenvironment-Related Treatment Resistance

Targeting Microenvironment-Mediated Radioresistance

References

Imaging for Target Volume Definition and Response Assessment in Lung Cancer

Abstract

Definition of GTV in Lung Cancer

Definition of the CTV in Lung Cancer

Emerging Applications of Imaging

Response Assessment

Conclusions

References

Advances in Technology and Its Application: Radiotherapy Treatment Planning

Abstract

Trends in Radiotherapy Treatment Planning

Standardization, Navigation, Automation

Diversification of Dose Prescription

Treatment of Geometrical Uncertainties

Conclusion

References

Stereotactic Body Radiotherapy

Historical Overview and Definition of Stereotactic Body Radiotherapy

SBRT for Early-Stage NSCLC

SBRT for Oligo-Metastatic Lung Cancer

SBRT for Oligo-Progressive Lung Cancer

Conclusion

References

Clinical Rationale and Indications for Particle Therapy

Abstract

Central Nervous System Tumors

Sarcoma

Head and Neck Cancer

Lung Cancer

Liver and Pancreatic Cancer

Gastrointestinal Cancer

Prostate Cancer

Gynecological Malignancies

Pediatric Cancer

Conclusion

References

Advances in Radiation Biology of Particle Irradiation

Abstract

DNA Damage and Repair

Hypoxia, Resistance, and New Approaches to Overcome It

Normal Tissue Tolerance and Implications for the RBE

Radiogenomics

Late Adverse Effects

Systemic Immune Response and Combined Treatments

Hypofractionation and SBRT

Conclusion

References

Preclinical Mouse Models for the Evaluation of Novel Techniques in Particle Therapy

Abstract

Preclinical Models for Particle Radiotherapy

Preclinical Evaluation for the Optimization of Carbon Ion Radiotherapy

Preclinical Evaluation of Spatial Fractionation for Particle Therapy

Preclinical Evaluation of Laser-Driven Particle Acceleration

References

Author Index

Subject Index

Cover

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