Description
Developments in radiation oncology have been key to the tremendous progress made in the field in recent years. The combination of optimal systemic treatment and local therapy has resulted in continuing improved outcomes of cancer therapy. This progress forms the basis for current pre-clinical and clinical research which will strengthen the position of radiation oncology as an essential component of oncological care. This book summarizes recent advances in radiotherapy research and clinical patient care. Topics include radiobiology, radiotherapy technology, and particle therapy. Chapters cover a summary and analysis of recent developments in the search for biomarkers for precision radiotherapy, novel imaging possibilities and treatment planning, and advances in understanding the differences between photon and particle radiotherapy. Advances in Radiation Therapy is an invaluable source of information for scientists and clinicians working in the field of radiation oncology. It is also a relevant resource for those interested in the broad topic of radiotherapy in general.
Chapter
Principles and Developments in Cancer Immunotherapy and Approaches for Combination with Tumour Irradiation
Historical Overview of Immunotherapy Development
Cancer Immunotherapy Concepts
Immunological Effects of Radiation, Rationale for Combination Therapies
Combination of Radiotherapy and Immunotherapy in the Clinic
Imageable Biomarkers for Radiotherapy Response
The Future of Biomarker Imaging for Radiotherapy
Targeting Tumor Microenvironment and Metabolism to Overcome Radiation Resistance
Role of the Tumor Microenvironment
Tumor Microenvironment-Related Treatment Resistance
Targeting Microenvironment-Mediated Radioresistance
Imaging for Target Volume Definition and Response Assessment in Lung Cancer
Definition of GTV in Lung Cancer
Definition of the CTV in Lung Cancer
Emerging Applications of Imaging
Advances in Technology and Its Application: Radiotherapy Treatment Planning
Trends in Radiotherapy Treatment Planning
Standardization, Navigation, Automation
Diversification of Dose Prescription
Treatment of Geometrical Uncertainties
Stereotactic Body Radiotherapy
Historical Overview and Definition of Stereotactic Body Radiotherapy
SBRT for Early-Stage NSCLC
SBRT for Oligo-Metastatic Lung Cancer
SBRT for Oligo-Progressive Lung Cancer
Clinical Rationale and Indications for Particle Therapy
Central Nervous System Tumors
Liver and Pancreatic Cancer
Gynecological Malignancies
Advances in Radiation Biology of Particle Irradiation
Hypoxia, Resistance, and New Approaches to Overcome It
Normal Tissue Tolerance and Implications for the RBE
Systemic Immune Response and Combined Treatments
Hypofractionation and SBRT
Preclinical Mouse Models for the Evaluation of Novel Techniques in Particle Therapy
Preclinical Models for Particle Radiotherapy
Preclinical Evaluation for the Optimization of Carbon Ion Radiotherapy
Preclinical Evaluation of Spatial Fractionation for Particle Therapy
Preclinical Evaluation of Laser-Driven Particle Acceleration