Regenerative Medicine and Cell Therapy ( Biomedical and Health Research )

Publication series : Biomedical and Health Research

Author: Stoltz J.-F.  

Publisher: Ios Press‎

Publication year: 2012

E-ISBN: 9781614990765

P-ISBN(Paperback): 9781614990758

Subject: R457.7 Bone Marrow Transplantation

Keyword: 生物化学

Language: ENG

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Description

Most human tissues do not regenerate spontaneously. Cell therapy and tissue engineering, which involve collecting cells from either the patient or a donor and introducing them into injured tissues or organs, sometimes after modifying their properties, offer promising solutions for regenerative medicine. Indeed, so promising are these therapies that current research has shifted from organ growth to cell therapy. The range of therapeutic applications is wide, including cardiac insufficiency, atherosclerosis, cartilage defects, bone repair, burns, diabetes and liver or bladder regeneration. This book, whilst not covering all aspects of regenerative medicine or cell therapy, offers a current overview of this emerging multidisciplinary field, which has been described as "the way to improve the health and quality of life by restoring, maintaining, or enhancing tissue and organ functions". It explores some of the problems and challenges encountered, such as the need to overcome risks of teratogenic effects and/or immune reactions, and deals with the legal issues involved in national regulations. The first 11 chapters of the book are devoted to basic knowledge of stem cells and the remaining 20 chapters deal with potential clinical applications: hematology, cardiac, vascular, osteoarticular, liver, skin, etc. - although of course it is impossible to envisage all of the applications which will undoubtedly be developed in the next decade or so. The book will be of interest to all res

Chapter

Mesenchymal Stem Cells in Regenerative Medicine

Umbilical Cord Mesenchymal Stem Cells: Biology and Clinical Application

Umbilical Cord Blood: From Current Use to Future Applications

Adipose Stem Cells: Identification, Properties and Interest for Clinical Applications

Circulating Stem Cells Including Endothelial Progenitor Cells

Cancer Stem Cells: The Example of Leukemic Stem Cells

Influence of Mechanical Forces on Cells and Tissues

Myofibroblasts: Origins and Regulation of Phenotype by Mechanical Signaling

Part II. Applications

Cell Therapy in Hematology: Hematopoietic Stem Cell Transplantations in 2012

Interaction Between Mesenchymal Stromal Cells and Acute Leukemia

Anti-Viral Immunotherapy After Allogeneic Hematopoietic Stem Cell Transplantation

Adipose Stromal/Stem Cell and Cardiovascular Repair

Bone Marrow-Derived Mesenchymal Stem Cells and Ischemic Cardiomyopathy

Heart Development and Cardiac Stem Cells

Cell Therapy for Muscular Dystrophies

Gene Therapy for the Treatment of Genetic Muscle Disease

Anti-Thrombogenic Strategies Toward Vascular Grafts Development

Neural Tissue Engineering Strategies

Chondrocytes and Mechanical Forces

Articular Cartilage Engineering

Chondrogenic Differentiation of Human Bone Marrow-Derived Mesenchymal Stem Cells

Mesenchymal Stem Cells in the Treatment of Cartilage Lesions

Subchondral Bone Alterations Associated with Marrow Stimulation for Articular Cartilage Repair - Experimental Data and Clinical Implications

Gene Therapy of Osteochondral Defects

Stem and Progenitor Cells for Liver Regenerative Medicine

Cell Therapy of Burns

Bioengineered Corneas: From Epithelial Cells Culture to 3D Models

Alternatives to Allogeneic Red Blood Cells Transfusion - In vitro Maturated Red Blood Cells a New Step in Cell Therapy

European Regulations of MSC for Clinical Uses

Author Index

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