Chapter
Section I: Molecular Identification of Natural & Synthetic Compounds
Application of NMR Spectroscopy for Structural Characterization of Bioactive Peptides Derived from Food Protein
1.2. A Review of Techniques Available for Structural Studies of Bioactive Peptides
2. PRINCIPLES OF NMR SPECTROSCOPY
2.1. General Principles of NMR Spectroscopy
2.2. Interaction of Nuclear Spins with Static Magnetic Field
2.3. The Phenomenon of Nuclear Magnetic Resonance
2.4. Sensitivity and the Boltzmann Equation
2.5. Chemical Shift and Scalar Spin-Spin Couplings
2.6. Rotating Frame of Reference in NMR
2.7. Radiofrequency (RF) Pulses and Vector Model
2.8. Pulse Sequences and the Pulsed Techniques Employed in Modern NMR Spectroscopy
2.8.1. Representation of a Single Pulse Sequence
2.8.2. Representation of a Two Pulse Spin-Echo Sequence
3. APPLICATION OF NMR SPECTROSCOPY TO STUDY THE STRUCTURES OF BIOACTIVE PEPTIDES
3.1. Choice of NMR Techniques for Structural Characterization of Bioactive Peptides
3.2. One Dimensional Proton (1H) NMR Experiments
3.3. 2D-NMR methods to Assign Backbone and Side Chain Proton Resonances in Bioactive Peptides
3.4. Chemical Shift Index (CSI] Based Method for Secondary Structure Determination of Bioactive Peptides
3.5. Computational Methods for Obtaining NMR Based Structures for Peptides and Proteins
3.5.1. Obtaining Distance Restraints from 2D-NOESY
3.5.2. Obtaining Information on the Dihedral Angels
3.5.3. Structure Calculation Procedures
4. STRUCTURE-ACTIVITY RELATIONSHIP AND MECHANISM OF ACTION OF BIOACTIVE PEPTIDES
4.1. Antimicrobial Peptides
4.1.1. Mechanisms of Action of AMPs
4.1.2. Structure-Activity Relationship of AMPs
4.2. ACE-Inhibitory and Antihypertensive Peptides
4.3. Antioxidative Peptides
4.4. Other Functional Peptides
Determination of GABA, Glutamate and Choline in the Auditory Pathway of Animals with Tinnitus, Using High Resolution Proton Magnetic Resonance Spectroscopy (1H-MRS)
MAGNETIC RESONANCE SPECTROSCOPY (MRS)
AN EXPERIMENTAL HYPOTHESIS
TINNITUS ASSESSSMENT IN ANIMALS
CONSIDERATIONS WHEN USING VOLUME-LOCALIZED 1H-MRS IN HIGH MAGNETIC FIELDS†
CALIBRATION, PREPARATION AND DATA ACQUISITION
REGIONAL LEVELS OF GABA, GLU, AND CHO
NMR Spectroscopy for the Characterization of Polymers
‘NMR’ SPECTROSCOPY FOR POLYMERS
POLYMERS AND POLYMER STRUCTURES
CHARACTERIZATION OF MONOMERS AND POLYMERS
Determination of Monomer Conversion Using NMR
NMR Analysis of a Vinyl Monomer and its Polymer
NMR Analysis of a Synthesized Difunctional Silane Monomer
DETERMINATION OF POLYMER TACTICITY
Determination of Tacticity of Polyacrylonitrile
NMR Analysis of Different Tactic Structures of Polypropylene
CHARACTERIZATION OF GEOMETRICAL ISOMERISM
ELUCIDATION OF COPOLYMER STRUCTURES
Determination of Copolymer Composition
Determination of Composition of SAN Copolymer
Determination of Composition of Copolymers of R-NPEMAM and HEMA
Determination of Monomer Reactivity Ratios
Determination of Monomer Sequence Distribution in a Copolymer Chain
ELUCIDATION OF POLYMER CHAIN BRANCHING
DETERMINATION OF MOLECULAR WEIGHTS OF POLYMERS
Determination of of Poly(ethylene terephphalate)
Determination of of Aromatic Poly(ether sulphone)
Determination of of a Block Copolymer
DETERMINATION OF AND MOLECULAR WEIGHT DISTRI-BUTION (MWD)
DETERMINATION OF CRYSTALLINITY IN POLYMERS
CHARACTERIZATION OF CARBON NANOMATERIALS CONTAINING POLYMERS
NMR Characterization of Fullerene (C60) Containing Polymers
NMR Characterization of Fullerene Containing Vinyl Polymers
NMR Characterization of Functionalized Carbon Nanotubes (CNTs)
Structure and Intramolecular Dynamics of Biologically Active Compounds: Analysis of NMR Spectra Transformed by Spin Labels
NMR IN PARAMAGNETC SYSTEMS
METHOD OF PARAMAGNETC ADDITIVES
NMR OF HETEROSPIN COMPLEXES
VINYL DERIVATIVES OF IMIDAZOLE AND PYRAZOLE
NMR SPECTRA OF 1-VINYLIMIDAZOLE
NMR SPECTRA OF 1-VINYLPYRAZOLE
Section II: Medical Diagnosis
NMR Spectroscopy in Brain Gliomas: Technique, Diagnosis, Grading and Follow-up after Therapy
Single-Voxel Spectroscopy (SVS)
Multivoxel Magnetic Resonance Spectroscopy Imaging (MRSI)
Differences with Nuclear Medicine
Role in the Identification of Radionecrosis
Role in the Identification Tumor Progression and Response
Section III: Food Sciences
Solid State NMR of Food and Biopolymers
2. SOLID STATE 13C NMR OF WHOLE FOODS
3. SOLID STATE 13C NMR OF WHEAT PROTEINS
4. SOLID STATE 13C NMR OF FAT AND FATTY ACIDS
5. SOLID STATE 13C NMR OF FOOD HYDROCOLLOIDS
6. STARCH SOLID STATE NMR
6.1. Role of Starches in Food
6.2. Solid State NMR of Starch