New Non-opioid Analgesics: Understanding Molecular Mechanisms on the Basis of Patch-clamp and Quantum-chemical Studies ( Frontiers in Pain Science )

Publication series ： Frontiers in Pain Science

Author： Boris V. Krylov Ilia V. Rogachevskii Tatiana N. Shelykh Vera B. Plakhova  

Publisher： Bentham Science Publishers‎

Publication year： 2017

E-ISBN: 9781608059300

P-ISBN(Hardback):  9781608059317

Subject： Q189 Neurobiology

Keyword： 神经科学

Language： ENG

Access to resources Favorite

Disclaimer: Any content in publications that violate the sovereignty, the constitution or regulations of the PRC is not accepted or approved by CNPIEC.

New Non-opioid Analgesics: Understanding Molecular Mechanisms on the Basis of Patch-clamp and Quantum-chemical Studies

Description

The monograph is a summary of methods used to study pain receptors and the results obtained in some experiments designed to study the effect of non-opioid analgesics. The molecular mechanisms of nociceptive information control in primary sensory nocicepti

Chapter

CONTENTS

PREFACE

Introduction and Methodology

PHYSIOLOGY OF PRIMARY SENSORY CODING

ROLE OF ION CHANNELS IN PRIMARY SENSORY CODING

Selectivity Filter

Inactivation Gating Device

Activation Gating Device

LIMITING SLOPE PROCEDURE

Mathematical Modeling of Zeff Evaluation by the Limiting Logarithmic Voltage Sensitivity Method

m-model

m3-model

m3h_s-model

m3h_f-model

PROBABLE ROLE OF EFFECTIVE CHARGE TRANSFER IN NOCICEPTIVE INFORMATION CODING

PATCH-CLAMP RESULTS OF ZEFF EVALUATION BY THE LIMITING LOGARITHMIC VOLTAGE SENSITIVITY METHOD

CONCLUSION

CONFLICT OF INTEREST

ACKNOWLEDGEMENTS

REFERENCES

Possible Mechanisms of Binding of Gamma-Pyrones to the Opioid-Like Receptor

PATCH-CLAMP INVESTIGATION OF GAMMA-PYRONES

QUANTUM-CHEMICAL STUDY OF GAMMA-PYRONES

Free Acids

Acid Anions

Sodium and Calcium Salts

Complexes with Ca2+

Sodium and Calcium Salts of Ca2+ Complexes

Energy Effects of Salt Formation and Ca2+ Chelation

CONCLUSION

CONFLICT OF INTEREST

ACKNOWLEDGEMENTS

REFERENCES

Possible Mechanisms of Binding of Gamma-Pyridones to the Opioid-Like Receptor

PATCH-CLAMP INVESTIGATION OF GAMMA-PYRIDONES

QUANTUM-CHEMICAL STUDY OF GAMMA-PYRIDONES

Free Acids

Complexes with Ca2+

Acid Anions

Calcium Salts

Сalcium Salts of Ca2+ Complexes

Energy Effects of Salt Formation and Ca2+ Chelation

Structure of Molecule F (5-hydroxy-2-hydroxymethyl-gamma-pyridone)

CONCLUSION

CONFLICT OF INTEREST

ACKNOWLEDGEMENTS

REFERENCES

Possible Mechanisms of Ligand-Receptor Binding of Cardiotonic Steroids

PATCH-CLAMP INVESTIGATION OF CARDIOTONIC STEROIDS

QUANTUM-CHEMICAL STUDY OF CARDIOTONIC STEROIDS

Ouabain and Ouabagenin

Ouabain–Ca2+ Chelate Complexes

Ouabagenin–Ca2+ Chelate Complexes

Marinobufagenin

CONCLUSION

CONFLICT OF INTEREST

ACKNOWLEDGEMENTS

REFERENCES

Concluding Remarks

OPIOID-LIKE RECEPTOR-COUPLED MECHANISM OF NAV1.8 CHANNELS MODULATION

TRANSDUCER-COUPLED MECHANISM OF NAV1.8 CHANNELS MODULATION

MODULATED RECEPTOR MECHANISM OF NAV1.8 CHANNELS CONTROL

CONFLICT OF INTEREST

ACKNOWLEDGEMENTS

GLOSSARY

REFERENCES

SUBJECT INDEX

The users who browse this book also browse


No browse record.