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Mesoporous Silica-based Nanomaterials and Biomedical Applications, Part A

Copyright

Contents

Contributors

Preface

Chapter One: Overview of Studies Regarding Mesoporous Silica Nanomaterials and Their Biomedical Application

1. Dramatic Increase in the Number of Publication Regarding Mesoporous Silica Nanomaterials

2. Synthesis of Mesoporous Silica Materials: Initial Discovery

3. Functionalization

4. Nanomachines and Controlled Drug Release

5. Biomedical Applications

6. Other Silica-Based Materials

Acknowledgments

References

Chapter Two: Structure Characterization of Mesoporous Materials by Electron Microscopy

1. Introduction

2. Basic Process for Obtaining Structure of SMCs

3. 2d-SMCs

4. 3d-SMCs

5. Cage-Type SMCs

6. Hyperbolic Surface Type

Acknowledgments

References

Chapter Three: Stimuli-Responsive Nanomachines and Caps for Drug Delivery

1. Introduction and Background

2. Internal/Autonomous Stimuli-Responsive Drug Delivery

2.1. pH-Sensitive Nano-Carriers

2.1.1. Reusable Valve

2.1.2. Reversible Valves

2.1.3. Swinging Gates

2.1.4. Molecular Recognition Based Gates

2.1.5. Nano Pistons

2.1.6. Megagates

2.1.7. Polymer-Based Gates

2.2. Redox-Sensitive Nano-Carriers

2.2.1. Rotaxane Based Redox-Nanovalves

2.2.2. Disulfide Based Redox-Nanovalves

2.2.3. Ferrocene-Based Redox-Nanovalves

2.3. Enzyme Triggered Delivery System

2.3.1. Snap-top Systems

2.3.2. Polymer-Based Systems

2.4. Antigen-Antibody Competitive Binding Delivery System

3. External Stimuli-Responsive Drug Delivery

3.1. Light-Activated Nanomachines

3.1.1. Impellers

3.1.2. Azobenzene/Cyclodextrin Valves

3.1.3. Photo-Cleavage

3.1.4. Plasmonic Heating

3.1.5. Transduced Photo-activation

3.1.6. Photoacid Transducers

3.1.7. Photo-redox Transducers

3.1.8. Energy Transfer (FRET) Transducers

3.2. Magnetic Field-Activated Nanomachines

3.2.1. Nanovalve Activation

3.2.2. Chemical Bond Breaking: Thermolysis

3.2.3. DNA Dehybridization

3.2.4. Phase-Changing Polymers

4. Future Directions

Acknowledgments

References

Chapter Four: Mesoporous Silica-Based Nanoparticles for Light-Actuated Biomedical Applications via Near-Infrared Two-Phot ...

1. Introduction

1.1. Benefits of Near-Infrared Absorption

1.2. Benefits of Two-Photon Absorption

2. Configuring Nanoparticles for Two-Photon-Actuated Therapy

2.1. Materials Design Strategies for Drug Delivery

2.2. Materials Design Strategies for Photodynamic Therapy

3. Two-Photon-Excited Drug Delivery

3.1. Silica-Coumarin Nanocomposites

3.2. Silica-Diphenyl-Butadiene Nanocomposites

3.3. Silica-Fluorophore-Azobenzene Nanocomposites

4. Two-Photon-Excited Photodynamic Therapy

4.1. Silica-Photosensitizer-Nanocomposites

4.2. Silica-Flurophore-Photosensitizer-Nanocomposites

4.3. Silica-Gold-Photosensitizer Nanocomposites

4.4. Silica-Diamond Nanocomposites

5. Two-Photon-Excited Multi-Therapy

5.1. Combining Drug Delivery and Photodynamic Therapy

5.2. Combining Photodynamic and Gene Silencing Therapy

6. Outlook

Acknowledgments

References

Chapter Five: Controlled Release With Emphasis on Ultrasound-Induced Release

1. Introduction

2. Ultrasound-Induced Release

2.1. General Aspects of Ultrasound

2.2. US-Responsive Materials

2.3. US-Responsive MSNs

3. Mesoporous Silica Nanoparticles With Light-Responsive Behavior

4. Mesoporous Silica Nanoparticles With Magnetic-Responsive Drug Release

5. Conclusions

Acknowledgments

References

Chapter Six: The Bioimaging Applications of Mesoporous Silica Nanoparticles

1. Introduction

2. Preparation of Fluorescence Dyes Functionalized MSNs

2.1. General Synthesis of Mesoporous Silica Nanoparticles

2.1.1. Ordered Mesoporous Silica (OMS)

2.1.2. Hollow/Rattle-Type Mesoporous Silica Nanoparticles

2.1.3. Core/Shell Type Mesoporous Silica Nanoparticles

2.2. Incorporated the Fluorescence Dyes With MSNs

3. FMSNs for Imaging at Cellular Levels

3.1. A Self-probe to Investigate the Cellular Interactions of MSNs

3.2. FMSNs for Labeling the Cell Surface Receptors

3.3. FMSNs for Intracellular Labeling, Tracking, and Sensing

3.4. FMSNs for Monitoring Control Release Process

4. Biodistribution and Fate of Functionalized MSNs

5. FMSNs as a Probe for In Vivo Cell Tracker

6. FMSNs for Tumor Imaging and the Theranostics Applications

7. Conclusions and Future Perspective

References

Chapter Seven: Biodistribution and Excretion of Intravenously Injected Mesoporous Silica Nanoparticles: Implications for ...

1. Introduction

2. Radiolabeling of MSNs

3. Biodistribution of MSNs

3.1. Overall Biodistribution of MSNs: Spherical Particles

3.2. Overall Biodistribution of MSNs: Influence of Particle Shape

3.3. Passive Versus Active Targeting of MSNs in Connection to Circulation Time

4. Excretion of MSNs

5. Conclusions and Outlook

References

Chapter Eight: Biodegradable Silica-Based Nanoparticles: Dissolution Kinetics and Selective Bond Cleavage

1. Introduction: From Silica to Silicas

1.1. From Silica to Silicas

1.2. Biodegradability in Context

2. Distinguishing Features of Silicas

2.1. Silica Nanoparticles

2.2. Silsesquioxane Nanoparticles

2.3. Silica Hybrid Nanoparticles

3. Biodegradable Silica: A Question of Kinetics

3.1. A Perspective From Nature

3.2. Tuning the Dissolution Kinetics

4. Biodegradable Silica Hybrids: Using Selective Bond Cleavage

4.1. Redox-Mediated Lysis

4.2. pH-Mediated Lysis

4.3. Enzymatic Mediated Lysis

4.4. Biochelation-Mediated Lysis

5. Outlook

Acknowledgments

References

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