Chapter
Chapter 1 Bioactive Glass Containing Coatings by Electrophoretic Deposition: Development and Applications
1.2 Electrophoretic Deposition
1.3 Bioactive Glass Coatings
1.4 Polymer/BG Composite Coatings
1.4.2 Degradable Polymer-BG Coatings
1.5 Incorporation of Drugs
1.6 Characterization of Coatings
Chapter 2 Multifunctional Bioactive Glasses and Glass-Ceramics: Beyond ‘Traditional’ Bioactivity
2.3 Antibacterial Properties
2.4 Promotion of Angiogenesis
2.5 Applications in Contact With Soft Tissues
2.6 Antioxidant Properties
2.7 Bone Cancer Treatment
2.8 Applications for Clinical Imaging and Biolabeling
Chapter 3 Synthesis and Characterization of Doped Bioactive Glasses
3.1 Bioactive Glasses Obtained by Melting at High Temperature—The Beginning
3.1.2 The SiO2-CaO-Na2O System
3.1.2.2 Selection of Compositions
3.1.2.3 Bioactivity of the SiO2-CaO-Na2O System
3.1.2.3.1 Bioactivity in Terms of HCA Nucleation Time
3.1.2.3.2 Bioactivity in Terms of Thickness
3.2 Doping of Glasses of the SiO2-CaO-Na2O System by P2O5 (Lebecq et al., 2007; Lebecq, 2002)
3.2.2 Selection of Compositions
3.2.3 Bioactivity of SiO2-CaO-Na2O-P2O5 System
3.2.3.1 Bioactivity in Terms of Time of HCA Layer’s Nucleation
3.2.3.2 Bioactivity in Terms of Thickness
3.2.4 Correlation Between Glass Structure and Bioactivity (Mercier et al., 2011; Pardini, 2007)
3.2.5 Development of a Doped Macroporous Bioactive Glass
3.3 Mixture Designs Applied to the SiO2-CaO-Na2O System Doped With P2O5 and CaF2
3.3.1 Selection of Doping
3.3.2 Mixture Designs (Goupy, 2000)
3.3.3 Results (Duée et al., 2012, 2013)
3.4 Improvement of the Mechanical Properties of Bioactive Glasses by Doping With Nitrogen
3.4.2 Selection of Glasses
3.4.3 N-Doping of Si-Na-Ca-O Glasses (Bachar et al., 2016)
3.4.3.1 Chemical Analysis
3.4.3.2 Structural Characterizations by 29Si NMR Spectroscopy
3.4.4 N-Doping of Si-Ca-Na-O-F System Glasses (Bachar et al., 2013a)
3.4.4.1 Chemical Analysis
3.4.4.2 Structural Characterizations by 29Si and 19F MAS NMR Spectroscopy (Bachar et al., 2013a)
3.4.5 Physicochemical Properties of Si-Ca-Na-O-N and Si-Ca-Na-O-F-N Glasses (Bachar et al., 2013b)
3.4.6 Mechanical properties Si-Ca-Na-O-N and Si-Ca-Na-O-F-N (Bachar et al., 2013b)
3.4.7 Bioactivity of Si-Ca-Na-O-N and Si-Ca-Na-O-F-N Glasses (Bachar, 2012)
3.5 Sol-Gel Quaternary Bioactive Glasses and Their Silver Doping
3.5.2 Sol-Gel Synthesis Methods for Invert Glasses
3.5.3 Results (Catteaux, 2015; Catteaux et al., 2013)
Part II Therapeutic Applications of Bioactive Glasses
Chapter 4 Mesoporous Bioactive Glasses: Fabrication, Structure, Drug Delivery Property, and Therapeutic Potential
4.2 Fabrication and Formation Mechanism of MBGs
4.2.1 Formation Mechanism of MBGs
4.3 MBGs as a Drug Delivery System for Therapeutic Application
4.3.1 Drug-Loading Mechanism and Release Kinetics of MBGs
4.3.2 Drug-Loaded MBGs for Enhanced Bactericidal Property
4.3.3 Drug-Loaded MBGs for Enhanced Bone Regeneration
Chapter 5 3D Scaffolds of Borate Glass and Their Drug Delivery Applications
5.2 Types of Biomaterials
5.3.1 Composition of Bone
5.4.2 Solid Porous Scaffolds
5.4.4 Extracellular Scaffolds
Chapter 6 Bioactive Glasses in Gene Regulation and Proliferation
6.2 Genes and Their Significance
6.4 Analytical Techniques for Gene Expression
6.5 Real-Time PCR as a Primary Tool for Gene Expression
6.5.1 Reverse Transcription
6.5.2 Polymerase Chain Reaction
6.6 Ionic Dissolution Products of Bioactive Glasses
6.7 Gene Expression/Regulation by Bioactive Glasses
6.8 Bioactive Glass in Osteoblast Proliferation
6.9 Conclusions and Outlook
Chapter 7 Lithium-Containing Bioactive Glasses for Bone Regeneration
7.2 Angiogenic Effects of Lithium-Containing Bioactive Glasses
7.3 Osteogenic Effects of Lithium-Containing Bioactive Glasses
7.4 Summary and Future Directions
Chapter 8 Boron-Containing Bioactive Glasses for Bone Regeneration
8.2.1 In Vitro Bioactivity and Biocompatibility
8.2.2 In Vivo Bioactivity
8.3.1 Silver-Doped Boron-Containing Bioactive Glass
8.3.2 Copper-Doped Boron-Containing Bioactive Glass
8.3.3 Zinc-Doped Boron-Containing Bioactive Glass
8.3.4 Strontium-Doped Boron-Containing Bioactive Glass
8.3.5 Rare Earth Elements-Doped Boron-Containing Bioactive Glass
8.4 Boron-Containing Bioactive Glasses for Wound Healing
Chapter 9 The Use of Bioactive Glasses in Periodontology
9.2 Treatment for Periodontal Disease
9.3 Nonglass Materials Used in Periodontal Therapy
9.5 Bone-Bonding by Bioactive Glass
9.6 Periodontal Applications of Bioactive Glasses
Chapter 10 Bioactive Glasses for Cancer Therapy
10.1 The Truth About Cancer
10.1.3 Signs and Symptoms
10.2 How to Destroy Cancer (Treatments)
10.2.7 Other Procedures and Techniques
10.3 Promising Bioactive Glass Treatments for Cancer
10.3.1 Hyperthermia Therapy for Cancer Treatment
10.3.2 Magnetic Bioactive Glasses for Hyperthermia Treatment
10.3.3 Bioactive Glass Applied in Brachytherapy
10.3.4 Mesoporous Bioactive Glasses for Targeted Tumor Therapy
10.4 Challenges and Perspective
Chapter 11 Bioactive Surface Coatings for Enhancing Osseointegration of Dental Implants
11.2 Surface Coating Techniques for Dental Implants
11.2.1 Physical Techniques
11.2.1.2 Low-Pressure Plasma Spraying
11.2.1.3 High-Velocity Oxy-Fuel Spraying
11.2.1.4 Sputter Deposition
11.2.1.5 Magnetron Sputtering
11.2.1.6 Ion Beam-Assisted Sputtering
11.2.1.7 Pulsed-Laser Deposition
11.2.2 Chemical Techniques
11.2.2.1 Sol-Gel Deposition
11.2.2.2 Electrophoretic Deposition
11.2.2.3 Electrochemical Deposition
11.2.2.4 Biomimetic Deposition
11.3 Bioactive Coating of Dental Implants
11.4 Key Properties of Bioactive Coatings
11.4.1 Bioactivity and Osseointegration
11.4.3 Ion Dissolution and Osteogenesis
11.4.4 Mechanical Performance
11.5 Conclusions and Future Prospects
Chapter 12 Angiogenic Attributes of Multifaceted Bioactive Glass: Its Therapeutic Potential on Soft Tissues and Drug Delive...
12.1 Fundamentals of Angiogenesis
12.1.1 Formation of Blood Vessels
12.2 Angiogenesis by Sprouting
12.3 Angiogenesis by Intussusception
12.6 Angiogenic Attributes of Bioglass on Soft Tissues
12.8 Effect of Bioglass on Dental Tissues
12.9 Drug Delivery Utilization
12.10 Bioglass in Drug Delivery for Tumor Growth Control
Part III Bioactive Glasses for Tissue Engineering and Regenerative Medicine
Chapter 13 Bioactive Glasses and Glass-Ceramics for Ophthalmological Applications
13.2 Context of Application and Clinical Background
13.7 Other Forms of Application
Chapter 14 Bioactive Glasses for Treatment of Bone Infections
14.1.1 Bone Tissue Infections
14.1.1.1 Osteomyelitis Classifications
14.1.1.2 Osteomyelitis Treatment Available in Clinics
14.1.2 Controlled Release
14.2.1 Antibacterial Activities of BGs
14.2.2 Antibacterial Activities of Doped BG
14.2.3 Antibacterial Activity of BGs for Release of Molecules
14.2.3.1 BGs for Release of Natural Compounds
14.2.3.2 BGs for Release of Drugs
14.2.3.3 Composites with BGs and Drugs
Chapter 15 Bioactive Glass Scaffolds for Bone Tissue Engineering
15.3 Fabrication of Bioactive Glass Scaffolds
15.3.1 Sol-Gel Processing
15.3.2 Thermal Bonding of Particles or Fibers
15.3.3 Polymer Foam Replication
15.3.4 Solid Freeform Fabrication (SFF)
15.3.5 Freeze Casting of Suspensions
15.4 Mechanical Perspective
15.4.2 Fracture Toughness and Reliability
15.4.3 Toughening of Porous Bioactive Glass Scaffolds
15.5 Biological Performance
15.6 Conclusions and Future Trends
Chapter 16 Functionally Graded Bioactive Glass-Derived Scaffolds Mimicking Bone Tissue
16.1 What We Want to Mimic—Features and Hierarchical Organization of Bone Tissue
16.2 Pore-Graded Bioactive Glass-Based Structures: A Short Overview
16.3 Mimicking the Trabecular-Cortical Bone System Through Pore-Graded Glass-Ceramic Scaffolds: A Case Study
16.3.1.2 Scaffold Fabrication
16.3.1.3 Characterization
16.3.2 Results and Discussion
Chapter 17 Bioactive Glass and Glass Fiber Composite: Biomedical/Dental Applications
17.1.1 Dental Restorative Materials
17.1.2 Development of Dental Composites
17.1.3 Role of Fillers in Dental Composites
17.1.3.1 Amorphous Calcium Phosphate
17.1.4 Biomedical Applications
17.1.4.1 Orthopedic Application
17.1.4.2 Cartilage Repair
17.1.6 Properties of Glass Fibers
17.1.6.1 Mechanical Properties
17.1.6.2 Thermal Properties
17.1.6.3 Biocompatibility
17.1.7 Dental Application
17.1.7.1 Prosthodontics Application
17.1.7.2 Endodontic Application
17.1.7.3 Tooth Restoration Application
17.1.7.4 Orthodontic Application
17.1.7.5 Periodontal Application
Chapter 18 Novel Techniques of Scaffold Fabrication for Bioactive Glasses
18.3 Types of Bioactive Glass
18.3.1 Silicate Bioactive Glass
18.3.2 Borate Bioactive Glass
18.3.3 Phosphate Bioactive Glass
18.4.1 What is a Scaffold/Template?
18.4.2 Materials of Scaffolds
18.4.3 2D and 3D Scaffolds Methods
18.5 Novel Techniques for the Synthesis of Scaffolds for Bioactive Glass
18.5.1 Melt Quenched Method
18.5.3 Mesoporous Bioactive Glass Scaffolds
18.5.3.1 Polyurethane Sponge Template (PUST) Method
18.5.3.2 One-Pot Synthesis Method for Synthesis of Magnetic and MMBGCs
18.5.3.3 3D Printing and Synergy With the Spin Coating Technique
18.5.3.4 Cetyltrimethylammonium Bromide (CTAB) Template Method
18.6 Application of Bioactive Glass in Biomedical Sciences
18.6.1.1 Treatment of Dental Hypersensitivity
18.6.3 Coating Enhancing Osseointegration
18.6.4 Wound Healing and Skin Repair
18.6.5 Nerve Tissue Regeneration
18.7 Future Trend of Bioactive Glass Scaffold
Chapter 19 Silica Nanospheres
19.2 Mechanism for Hollow Sphere Formation
19.2.2 Role of Surfactant
19.2.3 Rod-Shaped Mesoporous Silica
19.2.4 Mesoporous Silica Nanospheres
19.3 Role of Additives and Reaction Conditions on Mesoporous Silica Particles
19.3.1 Vesicular Mesoporous Silica
19.3.2 Rod-Like Mesoporous Silica
19.4 Functionalization of MSNs
19.4.1 Effect of Functionalization on Targeting
19.5.1 Factors Affecting Drug Loading
19.5.1.1 MSNs Hydrolytic Stability
19.5.1.2 MSN Dispersability
19.6 Drug Release and Dissolution
19.6.1 Dissolution and Release Kinetics
19.6.1.1 Particle Dissolution
19.7 Toxicity and Safety Consideration of MSNs
19.7.2 Porosity and Toxicity
19.7.3 Effect of Particle Size on Toxicity
Biomedical, Therapeutic and Clinical Applications of Bioactive Glasses
( Woodhead Publishing Series in Biomaterials )
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