Author： Wołyniec Elzbieta Niedzwiedzka Urszula Kojło Anatol
Publisher： Taylor & Francis Ltd
ISSN： 1073-9149
Source： Instrumentation Science & Technology, Vol.35, Iss.2, 2007-03, pp. : 219-231
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Abstract
A new flow-injection chemiluminescence method is proposed for the determination of catecholamines, including adrenaline, dopamine, and l-Dopa. The method is based on the chemiluminescence (CL) produced during the oxidation of catecholamines by sodium hypochlorite in an alkaline medium. The CL intensity is greatly increased when 2,7-dichlorofluoresceine is used as a sensitizer. The calibration graphs are linear in the range of 3-80 µg/mL for adrenaline and l-Dopa and 3-50 µg/mL for dopamine. The influence of foreign compounds was studied and the method was applied to the determination of catecholamines in pharmaceutical formulations.
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