Predicted amino acid sequences for 100 JCV strains

Author: Cubitt Christopher L   Cui Xiaohong   Agostini Hansjürgen T   Nerurkar Vivek R   Scheirich Iris   Yanagihara Richard   Ryschkewitsch Caroline F   Stoner Gerald L  

Publisher: Ashgate Publishing Ltd

ISSN: 1355-0284

Source: Journal of NeuroVirology, Vol.7, Iss.4, 2001-08, pp. : 339-344

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Abstract

DNA sequence variation between JCV genotypes is confined largely to noncoding intergenic regions and introns. Nevertheless, evidence suggests that the amino acid sequence variations among the 8 genotypes of JCV can influence the potential for neurovirulence of the virus. In the current study, the amino acid sequences for 100 JCV genomes were translated and grouped into genotype families. Subtype consensus sequences were determined and the type-specific amino acid sequence variants were identified. Journal of NeuroVirology (2001) 7, 339-344.