CLEAVAGE AUTOMATED: A new combinatorial chemistry tool

Author: Cook N. J.   Young K.   Stanley A. L.  

Publisher: Association for Laboratory Automation

ISSN: 1535-5535

Source: Journal of the Association for Laboratory Automation, Vol.5, Iss.2, 2000-05, pp. : 56-60

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Abstract

Liquid handling systems are in common use throughout the research chemistry industry, for a variety of fluid dispensing applications. However, few manual or automatic systems have been specifically designed for dosing highly corrosive acid/solvent mixes. Even fewer can withstand 60% Trifluoroacetic acid mixes - a standard mixture for cleavage of compound from polystyrene beads. A design is presented of such an automated dosing system. The requirements are to reduce human exposure to chemicals, remove potential for repetitive strain injury, and increase reaction plate throughput. Material choice, the use of process valves, equipment protection, and a novel plate detection system are discussed. Modifications resulting from the prototype test are discussed, along with additional improvements to the system and further research.