Population PKPD Modeling of BACE1 Inhibitor-Induced Reduction in Aβ Levels In Vivo and Correlation to In Vitro Potency in Primary Cortical Neurons from Mouse and Guinea Pig

Author： Janson Juliette   Eketjäll Susanna   Tunblad Karin   Jeppsson Fredrik   Berg Stefan   Niva Camilla   Radesäter Ann-Cathrin   Fälting Johanna   Visser Sandra  

Publisher： Springer Publishing Company

ISSN： 0724-8741

Source： Pharmaceutical Research, Vol.31, Iss.3, 2014-03, pp. : 670-683

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