Publisher： John Wiley & Sons Inc
E-ISSN： 1522-2586|42|3|666-672
ISSN： 1053-1807
Source： JOURNAL OF MAGNETIC RESONANCE IMAGING, Vol.42, Iss.3, 2015-09, pp. : 666-672
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Abstract
BackgroundTo validate DCE MRI method of placental perfusion estimation and to demonstrate application of the method in a rabbit model of fetal antenatal hypoxia‐ischemia.MethodsPlacental perfusion was estimated by dynamic contrast imaging with bolus injection of Gd‐DTPA in 3 Tesla GE magnet in a rabbit model of placental ischemia–reperfusion in rabbit dams at embryonic day 25 gestation age. Placental perfusion was measured using steepest slope method on DCE MRI before and after intermittent 40 min uterine ischemia. Antioxidants (n = 2 dams, 9 placentas imaged) or vehicle (n = 5 dams, 23 placenta imaged) were given systemically in a separate group of dams during reperfusion–reoxygenation. Placental perfusion was also measured in two dams from the antioxidant group (10 placentas) and two dams from the control group (12 placentas) by fluorescent microspheres method.ResultsWhile placental perfusion estimates between fluorescent microspheres and DCE MRI were significantly correlated (R2 = 0.85; P < 0.01), there was approximately 33% systematic underestimation by the latter technique. DCE MRI showed a significant decrease in maternal placental perfusion in reperfusion–reoxygenation phase in the saline, 0.44 ± 0.06 mL/min/g (P = 0.012, t‐test), but not in the antioxidant group, 0.62 ± 0.06 mL/min/g, relative to pre‐occlusion values (0.77 ± 0.07 and 0.84 ± 0.12 mL/min/g, correspondingly).ConclusionUnderestimation of true perfusion in placenta by steepest slope DCE MRI is significant and the error appears to be systematic. J. Magn. Reson. Imaging 2015;42:666–672.
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