The Phosphoinositide‐Gated Lysosomal Ca2+ Channel, TRPML1, Is Required for Phagosome Maturation

Publisher： John Wiley & Sons Inc

E-ISSN： 1600-0854|16|9|1010-1026

ISSN： 1398-9219

Source： TRAFFIC (ELECTRONIC), Vol.16, Iss.9, 2015-09, pp. : 1010-1026

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Abstract

TRPML1 is a lysosomal Ca2+ channel gated by phosphatidylinositol‐3,5‐bisphosphate, a signaling lipid that controls late endosome and lysosome function. Here, we show that TRPML1 is necessary to trigger fusion of lysosomes docked to phagosomes, for efficient killing of phagocytosed bacteria and the release of lysosomal Ca2+ into the cytosol after phagocytosis.

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