Synaptic Cytoskeletal Plasticity in the Prefrontal Cortex Following Psychostimulant Exposure

Publisher： John Wiley & Sons Inc

E-ISSN： 1600-0854|16|9|919-940

ISSN： 1398-9219

Source： TRAFFIC (ELECTRONIC), Vol.16, Iss.9, 2015-09, pp. : 919-940

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Abstract

Exposure to cocaine and amphetamine structurally reorganizes excitatory neurons in the medial and orbital prefrontal cortices (mPFC and oPFC), inducing dendritic spine proliferation in the mPFC and eliminating spines in the oPFC. Modifications may be causally associated with addiction etiology. Certain cytoskeletal regulatory proteins expressed in the oPFC and implicated in postnatal neural development also regulate behavioral sensitivity to cocaine, potentially opening a window of opportunity for the identification of novel pharmacotherapeutic targets in the treatment of drug abuse disorders.

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