Synthesis of Heterocycle‐fused Pyridine N‐Oxides from Oximes and Diazo Compounds via RhIII‐Catalyzed CH Activation and Annulation

Publisher： John Wiley & Sons Inc

E-ISSN： 1615-4169|357|11|2469-2473

ISSN： 1615-4150

Source： ADVANCED SYNTHESIS & CATALYSIS, Vol.357, Iss.11, 2015-08, pp. : 2469-2473

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Abstract

AbstractA RhIII‐catalyzed tandem CH activation and CN bond formation reaction between oximes and diazo compounds for the synthesis of heterocycle‐fused pyridine N‐oxides has been developed. The reaction exhibits good functional group tolerance and regioselectivity. After simple transformation, the 1‐substituted, 1,3‐disubstituted, 1,4‐disubstituted and 1,3,4‐trisubstituted heterocycle‐fused pyridines were all obtained in high efficiency. Moreover, this strategy has also been expanded to the synthesis of a key intermediate for the construction of one potential anti‐HIV agent.

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