Chapter
Specificity of Adaptive Response by Lymphocyte Receptors
Tight regulation of the immune system and associated responses
Chapter 2: Cells and Organs of the Immune System
Pluripotent Hematopoietic Stem Cells
Myeloid cells: first line of defense
Monocytes and Macrophages
Platelets and Erythrocytes
Lymphoid Cells: Specific and Long-Lasting Immunity
Primary and secondary lymphoid organs
Fetal Liver and Adult Bone Marrow
Secondary Lymphoid Organs
Mucosa-Associated Lymphoid Tissue
Chapter 3: Humoral Immunity
Antibody Structure and Function
Antibody-Antigen Interactions
Physiochemical Forces in Antigen-Antibody Interactions
Recognition of Sequential and Conformational Epitopes
Genetic basis of antibody structure
Generation of Antibody Diversity
Multiple Variable Gene Segments
Heavy and Light Chain Combinations
Junctional and Insertional Diversity
Isotype switching and affinity maturation
Chapter 4: T-Cell Immunity
Antigen-Specific Receptors
Genes Coding for T-Cell Receptors
Development of T lymphocytes
Unique effector functions of T-cell phenotypes
T Regulatory/Suppressor Cells
Chapter 5: Role of Major Histocompatibility Complex in the Immune Response
Function of the Major Histocompatibility Complex
Organization and High Polymorphism of MHC Genes and Gene Products
Structure of MHC class I and class II molecules
MHC and Antigen Presentation
Endogenous (Cytoplasmic) Antigen Processing and MHC Class I Presentation
Exogenous (Endosomal) Antigen Processing and MHC Class II Presentation
Role of MHC in Thymic Education
Role of MHC in Activation of T Cells
Association of Disease with MHC Haplotype
Atypical and unique antigen presentation
Superantigens Directly Bind T-Cell Receptors and MHC Without Processing
Presentation of Nonclassical Lipid Antigens to T Cells
Chapter 6: Innate Immunity
Physical Barriers Against Infection
Phagocytic and Endocytic Barriers
Defensive innate responding cells
Mononuclear Cells and Macrophages
Microbial Agent Recognition Through Pattern Recognition Receptors
Linking Innate and Adaptive Immune Responses
Natural Killer Cells: Early Defenders Against Infection
Complement in inflammation and immunity
Biologic Functions of Complement
Direct Cytolysis of Foreign Organisms
Opsonization of Foreign Organisms
Activation and Directed Migration of Leukocytes
Solubilization and Clearance of Immunocomplexes
Enhancement of Adaptive Immune Function
Chapter 7: Adaptive Immune Response and Hypersensitivity
T Cells: Primary Effectors for Cell-Mediated Immunity
Development of T Helper Cell Phenotypes
Role of T Cells in B-Cell Activation
Development of Cytotoxic T-Cell Effectors
Hypersensitivity: inappropriate response resulting in disease
Type I Hypersensitivity: Immunoglobulin E-Mediated Immediate Hypersensitivity
Type II Hypersensitivity: Antibody-Mediated Hypersensitivity
Type III Hypersensitivity: Immunocomplex-Mediated Hypersensitivity
Type IV Hypersensitivity: Delayed-Type (Cell-Mediated) Hypersensitivity
Chapter 8: Immunomodulation
Events involved in t-lymphocyte activation
Tolerance for specific control of immune response
Elimination of Self-Reactive Lymphocytes
Etiology of autoimmune disease
Transplantation: control of immune-mediated rejection
Mechanisms of Allograft Rejection
Immunosuppressive Agents to Prevent Allograft Rejection
Graft-Versus-Host Disease
Immunodeficiency disorders as a predisposition to infection
Immunoprophylaxis against infectious agents
Immune therapy for cancer
Interactions between polyclonal antibodies and multivalent antigens
Antibody-antigen interactions: The basis of quantitative and qualitative assays
Antibody-antigen precipitation reactions in gels
Double Diffusion Assay (Ouchterlony Assay)
Radial Immunodiffusion Assay
Monoclonal and polyclonal antibody specificity for antigen detection
Western Blot (Immunoblotting) Detection of Membrane-Bound Antigens
Enzyme-Linked Immunosorbent Assay
Immunohistochemical Methods
Fluorescence-Activated Cell Sorting
Assessment of immune function
General Inflammation Assessment
Lymphocyte Function Assays
Microarrays to Assess Gene Expression
Animal Models to Study Human Disease
ABO Blood Groups and Rh Incompatibility
Chapter 10: Infection and Immunity
Major immune defense mechanisms against pathogens
Parasitic Infections (Helminths)
Immune deviation: dominance of one response over another
Evasion of immune response
Chapter 11: Basic Bacteriology
Bacterial structure, function, and classification
General properties of prokaryotic organisms
Commensal organisms of the normal body flora
Methods of Genetic Transfer Between Organisms
Gene Expression and Regulation
Bacteremia, systemic inflammatory response syndrome, and sepsis
Bacterial toxins: virulence factors that trigger pathology
Major antimicrobial agents against bacteria
Chapter 12: Clinical Bacteriology
Streptococci and Enterococci
Other Gram-Positive Cocci of Medical Importance
Aerobic gram-positive bacilli
Anaerobic gram-positive bacilli
Eubacterium and Propionibacterium
Aerobic gram-negative bacilli
Other Pathogenic Enterobacteriaceae
Organisms of Zoonotic Origin
Campylobacter and Helicobacter
Anaerobic Gram-Negative Bacilli
Obligate Intracellular Pathogens
Rickettsia, Ehrlichia, and Coxiella
Mycobacterium tuberculosis
Acid-Fast Intestinal Coccidia
Chapter 13: Basic Virology
Viral Classification and Structure
Viral Genetic Material: RNA or DNA
Strategies for infectivity and replication
Viral disease patterns and pathogenesis
Therapy and prophylaxis for viral infections
Chapter 14: Clinical Virology
Respiratory Syncytial Virus
Mumps, measles, and other childhood exanthems
Human Herpes Simplex Virus Types 1 and 2
Human Herpesviruses 7 and 8
Human Immunodeficiency Virus
Japanese Encephalitis Virus
Fungal Structure and Classification
Laboratory Diagnosis of Fungal Infections
Immune Response to Fungal Agents
Superficial and Cutaneous Mycoses
Acanthamoeba and Naegleria
Laboratory diagnosis of parasitic infections
Immune response to parasitic infections
Elsevier's Integrated Review Immunology and Microbiology
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