Chapter
Chapter 1
Clinical Features and Natural History of Multiple Sclerosis:The Nature of the Beast
Disability Progression:
What Happens to Patients over Time?
What Affects Long-Term Disability Outcome?
Benign Multiple Sclerosis
Chapter 2
Differential Diagnosis and Diagnostic Criteria for Multiple Sclerosis: Application and Pitfalls
Multiple Sclerosis Diagnostic Criteria
Idiopathic Inflammatory Demyelinating
Diseases
Chapter 3
Uncovering the Genetic Architectureof Multiple Sclerosis
The MHC and Multiple
Sclerosis Susceptibility
A Meta-analysis of MHC Studies in Multiple Sclerosis
Whole Genome Scan Methodology and Its Application in Multiple Sclerosis
Genome Scan Results: What Do They Mean?
Susceptibility to Autoimmunity
The Impact and Role of Genetic Analysis in Multiple Sclerosis Research and Care
Chapter 4
Epidemiology of Multiple Sclerosis:Environmental Factors
Epidemiology in Perspective
Descriptive Epidemiology of Multiple Sclerosis
Infection and Multiple Sclerosis
Sunlight Exposure and Vitamin D
Other Possible Risk Factors
Chapter 5
Advances in Multiple Sclerosis Imaging
Physics of Magnetic
Resonance Imaging
High-Field-Strength Magnetic Resonance Imaging
Conventional Magnetic Resonance Imaging Techniques
The role of Magnetic Resonance Imaging in the Diagnostic Criteria of Multiple Sclerosis
The Role of Magnetic Resonance Imaging in Treatment Decisions
Advanced Magnetic Resonance Imaging Techniques
The Role of MRI in the Diagnosis of Tumefactive Demyelinating Lesions
Magnetic Resonance Imaging of Neuromyelitis Optica
Acute Disseminated Encephalomyelitis
Non–MRI-Based Advanced Imaging Techniques: Optical Coherence Tomography
Chapter 6
Biomarkers in Multiple Sclerosis
Definitions of Biomarkers
Biomarkers Related to Diagnosis and Prognosis
Biomarkers for Treatment Responses
Novel Technologies for the Identification of Novel Biomarkers
Chapter 7
Cognitive and Psychiatric Disorders in Multiple Sclerosis
Chapter 8
Gender Differences in Multiple Sclerosis
Gender Differences in Multiple Sclerosis
Gender Differences in the Murine Model of Multiple Sclerosis
The Effects of Pregnancy in Clinical Multiple Sclerosis
The Effects of Ovarian Hormones in Multiple Sclerosis
The Effects of Testicular Hormones in Multiple Sclerosis
Effect of Endogenous Androgens in the Mouse Model of Multiple Sclerosis
The Effects of Sex Chromosomes in Multiple Sclerosis
Chapter 9
Historical Background
Clinical Course of Multiple Sclerosis in Children
Investigations and Differential Diagnosis
Neuroimaging Features of Multiple Sclerosis in Children
Chapter 10
Clinically Isolated Syndromes
Clinical, Imaging, and Laboratory Predictors of Outcomein CIS
Medical Management of CIS
Chapter 11
Acute Disseminated Encephalomyelitis
Definitions of Acute Disseminated Encephalomyelitis
Clinical Characteristics of ADEM
Practical Recommendations for Clinicians
Chapter 12
Transverse Myelitis: Pathogenesis, Diagnosis, and Management
Diagnosis and Classification of Transverse Myelitis
Management and Treatment of Transverse Myelitis
Chapter 13
Neuromyelitis Optica
Clinical Presentation and Natural History
Chapter 14
Attack Therapies in Multiple Sclerosis
Glucocorticosteroid Therapy
for Acute Multiple Sclerosis Relapses
Plasma Exchange Therapy for Acute Deterioration in Relapsing and Secondary Progressive Multiple Sclerosis
Chapter 15
Current Disease-ModifyingTherapeuticStrategiesin MultipleSclerosis
General Therapeutic
Strategies for Multiple Sclerosis
Overview of Currently Approved Therapies
Treatment Strategies: Relapsing-Remitting Disease
Strategies for Secondary Progressive Multiple Sclerosis
Strategies for Primary Progressive Multiple Sclerosis
Strategies for Very Stable Patients: Stopping Therapy
Chapter 16
Management of Aggressive MultipleSclerosis: Optionsand Challenges
Diagnosis of Menacing Multiple Sclerosis
Use of Therapeutic Plasma Exchange, Cyclophosphamide, and Mitoxantrone in Catastrophic Multiple Sclerosis
Use of Mitoxantrone, Alemtuzumab,and Cyclophosphamide in Aggressive Multiple Sclerosis
Chapter 17
Symptomatic Therapy in Multiple Sclerosis
Chapter 18
Unconventional Medicineand Multiple Sclerosis: The Role of Conventional HealthProviders
Multiple Sclerosis: Conventional and Unconventional Medicine
Disease-Modifying and Symptomatic Effect
Chapter 19
Is Multiple Sclerosisa Neurodegenerative Disorder?
Neurologic Disability in Relapsing-Remitting Multiple Sclerosis
Neurologic Disability in Secondary Progressive Multiple Sclerosis
Chapter 20
Lessons from the Pastand Future Approachesfor Immunologic Therapies in Multiple Sclerosis
Chapter 21
Strategies to Promote Neuroprotectionand Repairin Multiple Sclerosis
The Immunologic Basis of
Central Nervous System Injury in Multiple Sclerosis and Its Relevance to Repair
Animal Models of Myelin Diseases
Does Immunomodulation Protect the Multiple Sclerosis Brain from Injury?
Novel Approaches for Neuroprotection in Multiple Sclerosis
Enhancing Repair Processes in Multiple Sclerosis
Is Stem Cell Therapy a Rational Approach for Multiple Sclerosis?
Multiple Sclerosis 3, Volume 34
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