Neonatology: Questions and Controversies Series

Author: Perlman> Jeffrey  

Publisher: Elsevier Health Sciences‎

Publication year: 2008

E-ISBN: 9781437721096

P-ISBN(Paperback): 9781416031574

Subject: R748 child neurology

Keyword: 神经病学与精神病学

Language: ENG

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Description

This exciting new reference brings you information about the most controversial neurological challenges you face in your practice. The book confidently tackles these subjects and gives seasoned advice on the latest diagnostic and treatment strategies using evidence-based medicine wherever possible. It gives you the latest information you need to keep pace with the fast-paced, dynamic environment of neonatology.Addresses controversial topics head on, so you can decide how to handle these difficult practice issues.Serves as the bridge between the latest cutting-edge research and its application to clinical practice. Assembles a world-class group of neonatologists, representing the true leaders of the specialty, to ensure the most authoritative content available.

Chapter

INTRODUCTION

DEFINITION OF HYPOTENSION

PATHOGENESIS AND DIAGNOSIS OF PATHOLOGIC CEREBRAL BLOOD FLOW

TREATMENT STRATEGIES

SUMMARY AND RECOMMENDATIONS

REFERENCES

Chapter 3 Intraventricular Hemorrhage and White Matter Injury in the Preterm Infant

CASE HISTORY

PERIVENTRICULAR-INTRAVENTRICULAR HEMORRHAGE

WHITE MATTER INJURY IN THE ABSENCE OF HEMORRHAGE

OUTCOME

GAPS IN KNOWLEDGE

CONCLUSIONS

REFERENCES

Chapter 4 Posthemorrhagic Hydrocephalus Management Strategies

CASE HISTORY

QUESTION 1. WHAT MEASUREMENTS OF VENTRICULAR SIZE ARE USED IN DIAGNOSIS OF PHVD?

QUESTION 2. HOW CAN WE DISTINGUISH VENTRICULAR DILATATION DRIVEN BY CSF UNDER PRESSURE FROM VENTRICULAR DILATATION DUE TO LOSS OF PERIVENTRICULAR WHITE MATTER?

QUESTION 3. HOW DO WE DEFINE EXCESSIVE HEAD ENLARGEMENT?

QUESTION 4. HOW DO WE RECOGNIZE RAISED INTRACRANIAL PRESSURE?

QUESTION 5. WHAT IS INFANT A’S PROGNOSIS?

QUESTION 6. WHAT IS THE MECHANISM OF PHVD?

QUESTION 7. HOW CAN PHVD INJURE WHITE MATTER?

QUESTION 8. WHAT INTERVENTIONS HAVE BEEN USED IN PHVD AND IS THERE ANY EVIDENCE OF IMPROVING OUTCOME?

OBJECTIVES IN TREATING PHVD

CURRENT MANAGEMENT STRATEGY

AREAS WHERE FURTHER RESEARCH IS NEEDED

REFERENCES

Chapter 5 Brain Cooling for Neonatal Encephalopathy: Potential Indications for Use

CASE HISTORY

ENCEPHALOPATHY AND HYPOXIA-ISCHEMIA

PATHOGENESIS OF HYPOXIC-ISCHEMIC BRAIN INJURY

DIAGNOSIS OF NEONATAL HIE

OUTCOME FOLLOWING NEONATAL HIE

POTENTIAL THERAPIES FOR NEONATAL HIE

CLINICAL EXPERIENCE WITH BRAIN COOLING FOR HIE

CLINICAL APPLICATION OF BRAIN COOLING

REFERENCES

Chapter 6 General Supportive Management of the Term Infant with Neonatal Encephalopathy Following Intrapartum Hypoxia-Ischemia

CASE HISTORY

DELIVERY ROOM MANAGEMENT

EARLY IDENTIFICATION OF INFANTS AT HIGHEST RISK OF DEVELOPING HYPOXIC-ISCHEMIC BRAIN INJURY

SUPPORTIVE CARE

GAPS IN KNOWLEDGE

REFERENCES

Chapter 7 Stroke in the Fetus and Neonate

CASE HISTORIES

DEFINITIONS

ETIOLOGY: RISK FACTORS

PATHOGENESIS

PATHOLOGY

INCIDENCE

CLINICAL MANIFESTATIONS

DIAGNOSIS

PROGNOSIS

CONCLUSIONS

REFERENCES

Chapter 8 Diagnosis and Treatment of Neonatal Seizures

INTRODUCTION

RECOGNITION OF NEONATAL SEIZURES

CLINICAL SEIZURE CRITERIA

NONEPILEPTIC BEHAVIORS OF NEONATES

ELECTROGRAPHIC SEIZURE CRITERIA

SUBCORTICAL SEIZURES VERSUS NONICTAL FUNCTIONAL DECORTICATION

SEIZURES IN THE CLINICAL CONTEXT OF MATERNAL–FETAL–PLACENTAL DISEASES: FOLLOWING A DIAGNOSTIC ALGORITHM

PRINCIPLES OF THERAPY

SUMMARY

REFERENCES

Chapter 9 Glucose and Perinatal Brain Injury: Questions and Controversies

GLUCOSE METABOLISM IN THE FETUS AND NEWBORN

CEREBRAL METABOLISM OF GLUCOSE

DEFINITIONS

SYMPTOMATIC VERSUS ASYMPTOMATIC HYPOGLYCEMIA

DURATION OF HYPOGLYCEMIA

CAUSES OF HYPOGLYCEMIA

HYPOGLYCEMIA AND BRAIN DAMAGE

ILLUSTRATIVE CASE

OUTCOME

TREATMENT

CONCLUSIONS

REFERENCES

Chapter 10 Neonatal Hypotonia

DEFINITION OF HYPOTONIA

PHYSICAL EXAMINATION AND ASSESSMENT OF A HYPOTONIC CHILD

DIFFERENTIAL ANATOMIC DIAGNOSIS OF HYPOTONIA

COMMON NEUROMUSCULAR DISORDERS PRESENTING PRINCIPALLY WITH HYPOTONIA

APPROACH TO HYPOTONIA

REFERENCES

Chapter 11 Hyperbilirubinemia and the Risk for Brain Injury

CASE HISTORY

PATHOGENESIS

APPROACHES: STRATEGIES FOR DIAGNOSIS AND TREATMENT

RECOMMENDATIONS FOR TREATMENT

GAPS IN KNOWLEDGE

REFERENCES

Chapter 12 Neonatal Meningitis: Current Treatment Options

CASE HISTORY

QUESTION 1. WHAT RISK FACTORS PREDISPOSE THIS INFANT TO HAVE EARLY-ONSET BACTERIAL MENINGITIS?

QUESTION 2. DO INFANTS WITH MENINGITIS HAVE POSITIVE BLOOD CULTURES?

QUESTION 3. WHAT IS THE OPTIMAL EVALUATION FOR POSSIBLE LATE-ONSET SEPSIS IN PRETERM INFANTS IN THE NICU?

QUESTION 4. WHAT IS THE EMPIRICAL ANTIMICROBIAL CHOICE FOR POSSIBLE LATE-ONSET SEPSIS IN THE NICU?

QUESTION 5. WHAT IS THE TREATMENT OF MENINGITIS IN NEONATES, AND IN PARTICULAR THAT DUE TO GRAM-NEGATIVE BACILLI?

QUESTION 6. SHOULD OTHER THERAPIES BE CONSIDERED?

QUESTION 7. WHAT IS THE DURATION OF TREATMENT FOR MENINGITIS IN NEONATES?

QUESTION 8. WHEN SHOULD NEUROIMAGING BE CONSIDERED AND WHAT TYPE OF EXAMINATION IS RECOMMENDED?

QUESTION 9. SHOULD OTHER ADJUNCTIVE THERAPIES BE PROVIDED TO AN INFANT WITH MENINGITIS?

QUESTION 10. WHAT IF THE INFANT’S CSF IS ABNORMAL BUT ROUTINE BACTERIAL CULTURES OF CSF AND BLOOD ARE STERILE?

QUESTION 11. WHAT IS THE OUTCOME OF MENINGITIS IN NEONATES?

CONCLUSIONS

REFERENCES

Chapter 13 Magnetic Resonance Imaging’s Role in the Care of the Infant at Risk for Brain Injury

THE TERM NEWBORN

CASE 1

CASE 2

CASE 3

CASE 4

CASE 5

CASE 6

CASE 7

THE PRETERM INFANT

CASE 8

CASE 9

CASE 10

CASE 11

REFERENCES

Chapter 14 Long-term Follow-up of Very Low Birth Weight Infants

OUTCOME: CEREBRAL PALSY AND OTHER NEUROLOGIC OR SENSORY SEQUELAE

THE 18- TO 24-MONTH-OLD CHILD

CASE 1

THE 3- TO 6-YEAR-OLD CHILD

CASE 2

THE SCHOOL AGE CHILD

CASE 3

THE ADOLESCENT AND YOUNG ADULT

CASE 4

GAPS IN KNOWLEDGE

CONCLUSIONS

REFERENCES

Index

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