Front Cover

Neuro-Oncology: Blue Books of Neurology Series

Copyright page

Blue Books of Neurology

Contents

Contributing Authors

Series Preface

Preface

Chapter 1: Pathology and Molecular Genetics of Common Brain Tumors

Introduction

Childhood Tumors

Common Adult Tumors

Conclusions

References

Chapter 2: Recent Advances in Epidemiology of Brain Tumors

Refinements in Histological Categorization of Brain Tumors and Associated Developments

Progress in Understanding the Descriptive Epidemiology of Brain Tumors

Advances in Identifying Prognostic Factors for Brain Tumors

Advances in Identifying Causal Factors for Brain Tumors

Established Environmental Causal Factors for Brain Tumors

Probable Causal Factors for Brain Tumors

Possible Causal Factors for Brain Tumors Requiring Additional Study

Summary

References

Chapter 3: Clinical Features of Brain Tumors

Introduction

Pathophysiology of Symptoms and Signs

Factors Determining Symptoms and Signs

Neurologic Symptoms and Signs

Primary Intra-axial Tumors

Primary Extra-axial Tumors

Brain Metastases

Conclusions

References

Chapter 4: Advanced Imaging of Adult Brain Tumors with MRI and PET

Introduction

Diffusion Weighted Imaging (DWI) of Cellularity

White Matter Invasion Assessment with Diffusion Tensor Imaging (DTI)

Spectroscopy of Tumor Metabolic Derangement

Perfusion and Permeability Imaging of Tumor Microvessels

Positron Emission Tomography in Brain Tumors

Summary

Acknowledgments

References

Chapter 5: Malignant Gliomas in Adults

Introduction

Epidemiology

Pathology

Molecular Pathogenesis

Cellular Origins

Diagnosis

Medical Management

Tumor-Directed Therapy (See Table 5-1)

Experimental Therapies

Conclusions

Acknowledgments

References

Chapter 6: Low Grade Astrocytomas

Introduction

Diffuse Astrocytoma, WHO Grade II

Pilocytic Astrocytoma

Other Astrocytoma Subtypes

References

Chapter 7: Oligodendrogliomas

Introduction

Frequency and Incidence

Histology

Molecular genetics

Clinical Features and Natural History

Imaging

Management

Prognosis

Conclusions

References

Chapter 8: Pediatric Neuro-Oncology

Introduction

Conclusions

References

Chapter 9: Primary CNS Lymphoma

Introduction

Pathology and Pathogenesis

Diagnosis and Workup

Treatment Options

Conclusions

References

Chapter 10: Management of Intramedullary Spinal Cord Tumors

Epidemiology and Presentation of Specific Intramedullary Spinal Cord Tumors

Diagnostic Imaging

Differential Diagnosis

Surgical Management

Postoperative Complications

Radiation Therapy

Chemotherapy

Outcome

Conclusions

References

Chapter 11: Extraaxial Brain Tumors

Introduction

Incidence and Epidemiology

Presentation

Diagnosis

Management

Conclusions

References

Chapter 12: Medical Complications in the Management of Brain Tumors

Introduction

Symptomatic Management

Prophylactic Perioperative Care

Complications Indirectly Related to the Tumor and Its Effects

Complications from Medical Treatment

Neurological and Psychiatric Postoperative Complications

Conclusions

References

Chapter 13: Brain Metastases

Introduction

Incidence

Presentation and Diagnosis

Prognosis

Medical Management

Specific Treatment Modalities

Management in Common Solid Tumors

Conclusions

References

Chapter 14: Spinal Metastases

Introduction

Vertebral Metastases

Vertebral Metastases with Epidural Extension

Intradural Metastases

References

Chapter 15: Neoplastic Meningitis

Introduction

Epidemiology

Pathogenesis

Clinical Features

Diagnosis

Staging

Prognosis

Treatment

Conclusions

References

Chapter 16: Neurotoxicity of Chemotherapy

Introduction

Types of Neurological Damage

Grading Toxicity

Prevention

Treatment of Neurotoxicity

Cytotoxic Agents and Their Neurological Toxicities (See Table 16-1)

Biological Agents

References

Chapter 17: Neurological Complications of Radiation Therapy

Introduction

Sequelae of Radiation Therapy to the Brain

Sequelae Of Radiotherapy To The Spinal Cord

Sequelae of Radiotherapy on the Cranial Nerves

Consequences of Radiotherapy on the Peripheral Nervous System

Conclusions

References

Chapter 18: Paraneoplastic Disorders

Introduction

Paraneoplastic Syndromes of the Brain

Paraneoplastic Disorders of the Visual System

Paraneoplastic Syndromes of the Spinal Cord and Dorsal Root Ganglia

Paraneoplastic Syndromes of the Nerves and Neuromuscular Junction

Paraneoplastic Syndromes of the Neuromuscular Junction

Paraneoplastic Disorders of the Muscle

References

Chapter 19: Neurological Complications of Bone Marrow and Organ Transplantation

Introduction

Clinical Syndromes

Neurotoxicity of Immunosuppressants

Neurological Complications Following Transplantation of a Specific Organ

References

Index