Pediatric Gastrointestinal and Liver Disease

Author: Wyllie> Robert  

Publisher: Elsevier Health Sciences‎

Publication year: 2010

E-ISBN: 9781437735666

P-ISBN(Paperback): 9781437707748

Subject: R725.7 infantile digestive system disease and coeliac disease

Keyword: 内科学

Language: ENG

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Disclaimer: Any content in publications that violate the sovereignty, the constitution or regulations of the PRC is not accepted or approved by CNPIEC.

Description

Pediatric Gastrointestinal and Liver Disease, by Drs. Robert Wyllie and Jeffrey S. Hyams provides the comprehensive reference you need to treat GI diseases in children. Review the latest developments in the field and get up-to-date clinical information on hot topics like polyps, capsule endoscopy, and pancreatic treatments. With expert guidance from an expanded international author base and online access to 475 board-review-style questions, this latest edition is a must-have for every practicing gastroenterologist.Confirm each diagnosis by consulting a section, organized by symptoms, that presents the full range of differential diagnoses and treatment options for each specific condition. Recognize disease processes at a glance with detailed diagrams that accurately illustrate complex concepts. Stay current with advances in the field by reviewing new chapters on Polyps and Polyposis Syndromes, Capsule Endoscopy and Small Bowel Enteroscopy, Small Bowel Transplantation, IBD, Short Gut Syndrome, Steatosis and Non-Alcoholic Fatty Liver Disease, and Pancreatic and Islet Cell Transplants. Gain fresh global perspectives from an expanded list of expert international contributors. Sharpen your visual recognition by accessing a color-plate section that displays additional endoscopy images. Prepare for certification or recertification with 475 online board review-style questions, answers, and rationales.

Chapter

Contents

Section 1 Biologic Aspects of Gastrointestinal Function

Chapter 1 - Development of the Gastrointestinal Tract

MORPHOGENESIS

MOLECULAR MECHANISMS

REFERENCES

Chapter 2 - Basic Aspects of Digestion and Absorption

CARBOHYDRATES

PROTEINS

LIPIDS

DIGESTION AND ABSORPTION IN INFANTS

VITAMINS AND MINERALS

MINERALS AND TRACE ELEMENTS

ACKNOWLEDGMENT

REFERENCES

FURTHER READINGS

Chapter 3 - Bile Acid Physiology and Alterations in the Enterohepatic Circulation

BIOSYNTHESIS

ENTEROHEPATIC CIRCULATION

MATURATION OF THE ENTEROHEPATIC CIRCULATION

ALTERATIONS IN THE ENTEROHEPATIC CIRCULATION

PEROXISOMAL DISORDERS

ALTERATION OF HEPATIC BILE ACID TRANSPORT

ALTERATION IN CHOLESTASIS (GENERAL)

ALTERATION OF THE ENTEROHEPATIC CIRCULATION OF BILE ACIDS

MECHANISM OF BILE ACID-INDUCED DIARRHEA

SUMMARY

REFERENCES

Chapter 4 - Indigenous Flora

UNDERSTANDING THE INDIGENOUS FLORA BY STUDYING GERM-FREE ANIMALS

ESTABLISHING THE INDIGENOUS FLORA

BACTERIAL FLORA WITHIN THE VARIOUS SECTIONS OF THE GASTROINTESTINAL TRACT

CONTROLLING THE GROWTH OF THE INDIGENOUS POPULATION

SYMBIOSIS BETWEEN HOST AND FECAL FLORA

BACTERIAL FLORA IN ILLNESS

BACTERIAL FLORA AND ALLERGY

BACTERIAL FLORA AND ANTIBIOTICS

BACTERIAL OVERGROWTH

TROPICAL SPRUE

PROBIOTICS

PREBIOTICS

SYNBIOTICS

REFERENCES

Chapter 5 - Physiology of Gastrointestinal Motility

ESOPHAGEAL MOTILITY

GASTRIC MOTILITY

MOTILITY OF THE SMALL INTESTINE AND COLON

ADDITIONAL MOTOR FUNCTIONS

SUMMARY

REFERENCES

Chapter 6 - Gastrointestinal Mucosal Immunology and Mechanisms of Inflammation

HIERARCHY OF GUT IMMUNE RESPONSES

GENERATION OF INFLAMMATION

MECHANISMS THAT PREVENT INFLAMMATORY REACTIONS TO GUT LUMINAL CONTENTS

ORGANIZATION OF THE MUCOSAL IMMUNE SYSTEM

COMPONENTS OF THE MUCOSAL IMMUNE SYSTEM

ESTABLISHMENT AND MAINTENANCE OF ORAL TOLERANCE TO ANTIGENS AND THE FLORA

PATTERNS OF INFLAMMATORY RESPONSE WITHIN THE INTESTINE

CONCLUSIONS

REFERENCES

Section 2 Clinical Problems

Chapter 7 - Chronic Abdominal Pain of Childhood and Adolescence

EVALUATION OF THE CHILD WITH CHRONIC ABDOMINAL PAIN

DIFFERENTIAL DIAGNOSIS

DIAGNOSIS OF CHILDHOOD FUNCTIONAL ABDOMINAL PAIN DISORDERS

THERAPEUTIC STRATEGY DEVELOPMENT

DIET

PHARMACOTHERAPY

PSYCHOLOGICAL THERAPIES

PROGNOSIS

PREVENTION

CONCLUSION

REFERENCES

Chapter 8 - Approach to the Child With a Functional Gastrointestinal Disorder

BIOMEDICAL MODEL

BIOPSYCHOSOCIAL MODEL

EARLY LEARNING-DEVELOPMENTAL ASPECTS OF FUNCTIONAL GASTROINTESTINAL DISORDERS

EFFECTIVE REASSURANCE

BIOMEDICAL VERSUS BIOPSYCHOSOCIAL MODELS

TREATMENT

APPROACH TO THE CHILD OR ADOLESCENT WITH PAIN-ASSOCIATED DISABILITY SYNDROME

WHAT SHOULD A PEDIATRIC GASTROENTEROLOGY CONSULTATION ACCOMPLISH?

PEDIATRIC FUNCTIONAL GASTROINTESTINAL DISORDERS

CONCLUSION

REFERENCES

Chapter 9 - Vomiting and Nausea

VOMITING EVENT

CLINICAL ASPECTS OF VOMITING

CLINICAL ASPECTS OF NAUSEA

SPECIFIC VOMITING DISORDERS

REFERENCES

Chapter 10 - Diarrhea

PHYSIOLOGY OF INTESTINAL CONTENT HANDLING

DEFINITIONS OF DIARRHEA

CLINICAL OBSERVATIONS OF TYPES OF DIARRHEA

PATHOPHYSIOLOGY OF SECRETORY DIARRHEA

PATHOPHYSIOLOGY OF OSMOTIC DIARRHEA

PATHOPHYSIOLOGY OF INFLAMMATORY DIARRHEA

CLINICAL RELEVANCE OF ACUTE INFECTIOUS DIARRHEA

DIFFERENTIAL DIAGNOSIS

APPROACH TO THE CHILD WITH DIARRHEA

CLINICAL MANAGEMENT

REFERENCES

Chapter 11 - Colic and Gastrointestinal Gas

GASTROINTESTINAL GAS

COLIC

CONCLUSIONS

REFERENCES

Chapter 12 - Constipation and Fecal Incontinence

PATHOPHYSIOLOGY

FUNCTIONAL CONSTIPATION IN INFANTS AND TODDLERS

FUNCTIONAL CONSTIPATION IN CHILDREN AND ADOLESCENTS

COMPLICATIONS OF CONSTIPATION

FUNCTIONAL FECAL INCONTINENCE

INVESTIGATIONS

TREATMENT

OUTCOME

REFERENCES

Chapter 13 - Failure to Thrive

EPIDEMIOLOGY

DEFINITION

NORMAL GROWTH PATTERNS

PATHOGENESIS

CAUSES AND CONTRIBUTORY FACTORS

EVALUATION OF FAILURE TO THRIVE

INVESTIGATIONS

MANAGEMENT

OUTCOME

GROWTH OUTCOME

CONCLUSION

ACKNOWLEDGMENTS

REFERENCES

Chapter 14 - Gastrointestinal Hemorrhage

THERAPY

CONCLUSIONS

REFERENCES

Chapter 15 - Obesity

DEFINITIONS

EPIDEMIOLOGY

ETIOLOGY AND PATHOGENESIS

ASSESSMENT OF THE OBESE CHILD

TREATMENT

CONCLUSIONS

REFERENCES

Chapter 16 - Eating Disorders in Children and Adolescents

CHANGING FACE OF THE EPIDEMIOLOGY

ASPECTS OF THE HISTORY AND PHYSICAL EXAMINATION

MEDICAL COMPLICATIONS OF EATING DISORDERS

AMENORRHEA AND OSTEOPENIA

PROGNOSIS: BONE, BRAINS, AND BABIES (OR FUTURE FERTILITY)

NEXT STEP

PREVENTION: HOW CAN WE DO BETTER?

REFERENCES

Chapter 17 - Jaundice

BILIRUBIN METABOLISM

ASSESSMENT OF JAUNDICE

NEONATAL JAUNDICE

JAUNDICE IN INFANTS AND OLDER CHILDREN

REFERENCES

Chapter 18 - Ascites

ETIOLOGY

PATHOPHYSIOLOGY

DIAGNOSIS

TREATMENT

SPONTANEOUS BACTERIAL PERITONITIS

References

Chapter 19 - Caustic Ingestion and Foreign Bodies

INGESTION OF CAUSTIC AGENTS

MECHANISMS OF DAMAGE TO THE GASTROINTESTINAL TRACT

LOCATION OF INJURY

MANAGEMENT OF CAUSTIC INGESTION

FOLLOW-UP AND LONG-TERM MANAGEMENT

INGESTION OF FOREIGN BODIES

ACUTE MANAGEMENT OF FOREIGN BODIES

References

Chapter 20 - Developmental Anatomy and Physiology of the Esophagus

DEVELOPMENTAL ANATOMY

GENETIC AND MOLECULAR ASPECTS OF TRACHEOESOPHAGEAL DEVELOPMENT

ANATOMY

PHYSIOLOGY

PATHOPHYSIOLOGY

SUMMARY

REFERENCES

Section 3 The Esophagus

Chapter 21 - Congenital Malformations of the Esophagus

CONGENITAL LESIONS OF THE ESOPHAGUS

CONGENITAL ESOPHAGEAL STENOSIS

ESOPHAGEAL ATRESIA AND TRACHEOESOPHAGEAL FISTULA

LARYNGOTRACHEOESOPHAGEAL CLEFTS

Chapter 22 - Gastroesophageal Reflux

DEFINITIONS

ENVIRONMENTAL AND GENETIC FACTORS

PATHOPHYSIOLOGY

SYMPTOMS AND SIGNS

DIAGNOSIS

TREATMENT OPTIONS

CONCLUSION

References

Chapter 23 - Achalasia and Other Motor Disorders

DISORDERS OF THE PROXIMAL ESOPHAGUS

DISORDERS OF THE DISTAL ESOPHAGUS

REFERENCES

Chapter 24 - Other Diseases of the Esophagus

ESOPHAGEAL SYMPTOMS

ESOPHAGEAL INFECTIONS

ESOPHAGEAL TUMORS

REFERENCES

Section 4 The Stomach

Chapter 25 - Developmental Anatomy and Physiology of the Stomach

HISTOLOGY

NEUROMUSCULAR FUNCTIONS

GASTRIC SECRETIONS

GASTRIC ACID SECRETION

OTHER HORMONES AND PEPTIDES

PEPSINOGEN

MUCUS AND BICARBONATE SECRETION

GASTRIC LIPASE

INTRINSIC FACTOR

REFERENCES

Chapter 26 - Congenital Anomalies and Surgical Disorders of the Stomach

EMBRYOLOGY

HYPERTROPHIC PYLORIC STENOSIS

FOVEOLAR HYPERPLASIA

GASTRIC OUTLET OBSTRUCTION

GASTRIC VOLVULUS

CONGENITAL MICROGASTRIA

GASTRIC PERFORATION

GASTRIC AND DUODENAL DUPLICATIONS

POLYPS

TUMORS

REFERENCES

Chapter 27 - Gastritis, Gastropathy, and Ulcer Disease

CLINICAL PRESENTATION

DIAGNOSTIC METHODS

APPROACH TO GASTRITIS

GASTRITIS

PEPTIC ULCER DISEASE

DIAGNOSIS

MANAGEMENT

REFERENCES

Chapter 28 - Helicobacter pylori in Childhood

EPIDEMIOLOGY

HOST FACTORS AND RESPONSES

BACTERIAL FACTORS AND ADAPTATIONS

DISEASE ASSOCIATIONS

DIAGNOSIS

TREATMENT

CONCLUSION

REFERENCES

Chapter 29 - Gastric Motility Disorders

GASTRIC MOTOR PHYSIOLOGY AND GASTRIC EMPTYING

DISORDERS OF GASTRIC FUNCTION

ASSESSMENT OF GASTRIC MOTOR AND SENSORY FUNCTION

TREATMENT

REFERENCES

Chapter 30 - Bezoars

DEFINITIONS

EPIDEMIOLOGY

ETIOLOGY AND PATHOGENESIS

CLINICAL PRESENTATION

DIAGNOSIS

TREATMENT

PREVENTION

REFERENCES

Section 5 The Small and Large Intestine

Chapter 31 - Anatomy and Physiology of the Small and Large Intestines

INTESTINAL ANATOMY

PHYSIOLOGY OF WATER AND ION TRANSPORT

REFERENCES

Chapter 32 - Maldigestion and Malabsorption

CLASSES OF NUTRIENTS

DIAGNOSTIC APPROACH

MANAGEMENT

REFERENCES

Chapter 33 - Protracted Diarrhea

Definitions, Epidemiology, and Risk Factors

PATHOPHSYSIOLOGY OF PROTRACTED DIARRHEA

ASSESSMENT OF THE PATIENT WITH PROTRACTED DIARRHEA

ACKNOWLEDGMENTS

REFERENCES

Chapter 34 - Protein-Losing Enteropathy

PATHOPHYSIOLOGY

CAUSES OF PLE

DIAGNOSIS

TREATMENT

REFERENCES

Chapter 35 - Celiac Disease

DEFINITION

HISTORICAL BACKGROUND

CEREAL PROTEINS AND OTHER ENVIRONMENTAL FACTORS

GENETICS OF CELIAC DISEASE

EPIDEMIOLOGY

PATHOGENESIS

PATHOLOGY

CLINICAL PRESENTATION

ASSOCIATED DISEASES

LABORATORY FINDINGS

DIAGNOSIS

THERAPY

REFERENCES

Chapter 36 - Short Bowel Syndrome

DEFINITION

ETIOLOGY

INTESTINAL FUNCTION AND THE IMPACT OF INTESTINAL LOSS

FACTORS THAT DETERMINE PROGNOSIS OF SBS

CLINICAL MANAGEMENT OF SBS

ADDITIONAL MEDICAL INTERVENTIONS

COMPLICATIONS OF SBS AND PN

SURVIVAL AND ITS COSTS IN PEDIATRIC SBS

SUMMARY

REFERENCES

Chapter 37 - Small Bowel Transplant

HISTORY

INDICATIONS AND REFERRAL

PRETRANSPLANT NUTRITIONAL MANAGEMENT

CHOICE OF ALLOGRAFT

DONOR AND RECIPIENT OPERATIONS

POSTOPERATIVE MANAGEMENT

POSTTRANSPLANT NUTRITIONAL MANAGEMENT

NURSING IMPLICATIONS

OUTCOMES

FUTURE PROSPECTS

REFERENCES

Chapter 38 - Allergic and Eosinophilic Gastrointestinal Disease

FOOD ALLERGY OR HYPERSENSITIVITY

EOSINOPHILIC GASTROENTEROPATHIES

EOSINOPHILIC ESOPHAGITIS

EOSINOPHILIC GASTROENTERITIS

EOSINOPHILIC PROCTOCOLITIS

OTHER MANIFESTATIONS OF GASTROINTESTINAL ALLERGY

CONCLUSION

REFERENCES

Chapter 39 - Infectious Diarrhea

VIRAL GASTROENTERITIS

BACTERIAL GASTROENTERITIS

POTENTIAL DIARRHEAGENIC ORGANISMS

CONCLUSION

REFERENCES

Chapter 40 - Enteric Parasites

EPIDEMIOLOGY

HOST FACTORS

CLINICAL PRESENTATIONS

DIAGNOSIS

BENEFITS OF PARASITES

PATHOGENIC ORGANISMS

REFERENCES

Chapter 41 - Gastrointestinal Manifestations of Primary Immunodeficiency

INNATE VERSUS ADAPTIVE IMMUNITY

COMPONENTS OF THE ADAPTIVE IMMUNE RESPONSE

HUMORAL IMMUNODEFICIENCIES

CELLULAR IMMUNODEFICIENCIES

COMBINED CELLULAR-HUMORAL IMMUNODEFICIENCIES

DISORDERS OF PHAGOCYTE FUNCTION

OTHER PRIMARY IMMUNODEFICIENCIES

References

Chapter 42 - Gastrointestinal Complications of Secondary Immunodeficiency Syndromes

PEDIATRIC HIV INFECTION

HIV AND THE CELLULAR COMPONENTS OF THE GASTROINTESTINAL TRACT

STRUCTURE AND FUNCTION OF THE INTESTINAL TRACT IN HIV INFECTION

INFECTIONS OF THE GASTROINTESTINAL TRACT

INFECTIONS OF THE GASTROINTESTINAL TRACT IN REGIONS WITH LOW HAART ACCESSIBILITY OR IN PATIENTS WITH CD4 COUNTS BELOW 200 CELLS/...

INFECTIONS OF THE GASTROINTESTINAL TRACT IN REGIONS WITH HIGH HAART ACCESSIBILITY AND SUCCESSFUL HIV VIRAL SUPPRESSION

MOTILITY OF THE GASTROINTESTINAL TRACT IN HIV INFECTION

IDIOPATHIC ESOPHAGEAL ULCERATION

CLINICAL MANAGEMENT OF GASTROINTESTINAL DISORDERS IN HIV INFECTION AND OTHER IMMUNODEFICIENCIES

OTHER SECONDARY IMMUNODEFICIENCIES

LIVER COMPLICATIONS IN SECONDARY IMMUNODEFICIENCY

SUMMARY

References

Chapter 43 - Pediatric Polyposis Syndromes

Histopathologic Classification

Clinical Management

FAMILIAL ADENOMATOUS POLYPOSIS

JUVENILE POLYP (SOLITARY AT DIAGNOSIS)

JUVENILE POLYPOSIS SYNDROME

PTEN – HAMARTOMA TUMOR SYNDROME

PEUTZ-JEGHERS SYNDROME (PJS)

OTHER POLYPOSIS SYNDROMES

SUMMARY

References

Chapter 44 - Crohn’s Disease

EPIDEMIOLOGY

ETIOLOGY

PATHOLOGY

PATHOPHYSIOLOGY OF GASTROINTESTINAL SYMPTOMS

CLASSIFICATION OF SUBGROUPS IN CROHN’S DISEASE

CLINICAL FEATURES

DIAGNOSIS

DIFFERENTIAL DIAGNOSIS

THERAPY

NATURAL HISTORY

ACKNOWLEDGMENT

References

Chapter 45 - Ulcerative Colitis in Children and Adolescents

EPIDEMIOLOGY

GENETICS

ETIOLOGY

PATHOLOGY

CLINICAL FEATURES

EXTRAINTESTINAL MANIFESTATIONS

COMPLICATIONS

DIAGNOSIS

DIFFERENTIAL DIAGNOSIS

MEDICAL THERAPIES

SURGERY

COURSE AND PROGNOSIS

References

Chapter 46 - Chronic Intestinal Pseudo-obstruction

ETIOLOGY

PATHOLOGY

CLINICAL FEATURES

TREATMENT

OUTCOMES

REFERENCES

Chapter 47 - Neonatal Necrotizing Enterocolitis

EPIDEMIOLOGY

PATHOLOGY

PATHOGENESIS

CLINICAL MANIFESTATIONS

DIAGNOSIS

PREVENTION

MANAGEMENT

OUTCOME

References

Chapter 48 - Disorders of the Anorectum:

ANAL FISSURE

RECTAL PROLAPSE

FISTULAS

HEMORRHOIDS

TAGS AND MISCELLANEOUS CONDITIONS

REFERENCES

Chapter 49 - Neoplasms of the Gastrointestinal Tract and Liver

NEOPLASMS OF THE LUMINAL GASTROINTESTINAL TRACT

NEOPLASMS OF LYMPHOID ORIGIN

NEOPLASMS OF EPITHELIAL ORIGIN

NEOPLASMS OF MESENCHYMAL ORIGIN

NEOPLASMS OF THE LIVER

REFERENCES

Chapter 50 - Other Diseases of the Small Intestine and Colon

HENOCH-SCHÖNLEIN PURPURA

ACRODERMATITIS ENTEROPATHICA

HEMOLYTIC UREMIC SYNDROME

RADIATION ENTERITIS

MALAKOPLAKIA

BEHÇET’S SYNDROME

TYPHLITIS

MICROSCOPIC COLITIS

EHLERS-DANLOS SYNDROME

PNEUMATOSIS INTESTINALIS

SOLITARY RECTAL ULCER SYNDROME AND COLITIS CYSTICA PROFUNDA

AMYLOIDOSIS

INTESTINAL GRAFT-VERSUS-HOST DISEASE

REFERENCES

Chapter 51 - Appendicitis

EMBRYOLOGY AND ANATOMY

PATHOPHYSIOLOGY

HISTOLOGY

CLINICAL PRESENTATION

PATIENT EVALUATION

DIAGNOSTIC TESTS

MANAGEMENT OPTIONS

DIFFERENTIAL DIAGNOSIS

COMPLICATIONS

CHRONIC APPENDICEAL PAIN

REFERENCES

Section 6 Pediatric Surgical Disorders

Chapter 52 - Intussusception in Infants and Children

PATHOPHYSIOLOGY

ETIOLOGY

CLINICAL PRESENTATION

DIAGNOSTIC WORK-UP

THERAPEUTIC OPTIONS

RECURRENCE

SPECIAL CONSIDERATIONS

REFERENCES

Chapter 53 - Inguinal Hernias and Hydroceles

PATHOGENESIS

CLINICAL PRESENTATION

MANAGEMENT

COMPLICATIONS

REFERENCES

Chapter 54 - Meckel’s Diverticulum and Other Omphalomesenteric Duct Remnants

EMBRYOLOGY AND ANATOMY

CLINICAL PRESENTATION

DIAGNOSIS

TREATMENT

SUMMARY

REFERENCES

Chapter 55 - Hirschsprung’s Disease

EPIDEMIOLOGY AND GENETICS

PATHOPHYSIOLOGY

CLINICAL PRESENTATION

DIFFERENTIAL DIAGNOSIS

DIAGNOSIS

TREATMENT

RESULTS OF SURGICAL THERAPY

SUMMARY

REFERENCES

Chapter 56 - Imperforate Anus

CLASSIFICATION AND DESCRIPTION OF DEFECTS

ASSOCIATED DEFECTS

EARLY MANAGEMENT AND DIAGNOSIS

MAIN REPAIR

FUNCTIONAL SEQUELAE

References

Chapter 57 - Abnormal Rotation and Fixation of the Intestine

EMBRYOLOGY

ANATOMY

CLINICAL PRESENTATION

DIAGNOSIS

TREATMENT

COMPLICATIONS, RESULTS, OUTCOME

SUMMARY

References

Chapter 58 - Small and Large Bowel Stenosis and Atresias

DUODENAL STENOSIS AND ATRESIA

SMALL BOWEL ATRESIA

COLONIC ATRESIA

SUMMARY

References

Chapter 59 - Newborn Abdominal Wall Defects

HISTORICAL BACKGROUND AND TERMINOLOGY

EMBRYOGENESIS DICTATES THE TYPE OF DEFECT

FACTORS THAT MAY CAUSE THE DEFECT

A CHANGING EPIDEMIOLOGY

A SPECTRUM OF DEFECTS

ASSOCIATED ANOMALIES (THE MAJOR DETERMINANT OF MORBIDITY AND MORTALITY)

PRENATAL MANAGEMENT

INITIAL MANAGEMENT AFTER DELIVERY

SPECIFIC MANAGEMENT OF THE DEFECT

POSTOPERATIVE MANAGEMENT

ALTERNATIVE METHODS OF CLOSURE

EXPECTED MORTALITY

INCREASING HOSPITAL COSTS

POSTOPERATIVE COMPLICATIONS

LATE MORBIDITY AND QUALITY OF LIFE

References

Chapter 60 - Stomas of the Small and Large Intestine

HISTORICAL NOTE

CHILD WITH A STOMA

TYPES OF INTESTINAL STOMA AND THEIR APPLICATIONS

INDICATIONS FOR ENTEROSTOMIES IN CHILDREN

CHOICE OF ENTEROSTOMY

TECHNICAL ASPECTS

STOMA CARE

REESTABLISHING INTESTINAL CONTINUITY

COMPLICATIONS OF ENTEROSTOMIES AND THEIR MANAGEMENT

OSTOMY TRENDS

References

Section 7 GastrointestinalProcedures

Chapter 61 - Esophagogastroduodenoscopy and Related Techniques

PERSONNEL

FACILITIES

EQUIPMENT

INDICATIONS

CONTRAINDICATIONS

ANTIBIOTIC PROPHYLAXIS

PREPARATION

SEDATION AND MONITORING

ANATOMY

TECHNIQUE

BIOPSY TECHNIQUE

Stomach

THERAPEUTIC ENDOSCOPY

INJECTION

THERMOCOAGULATION

ELECTROCOAGULATION

STRICTURE DILATION

SMALL BOWEL ENTEROSCOPY

WIRELESS CAPSULE ENDOSCOPY

PERCUTANEOUS ENDOSCOPIC GASTROSTOMY

PERCUTANEOUS ENDOSCOPIC JEJUNOSTOMY (PEJ)

POLYPECTOMY

SPECIAL ENDOSCOPIC TECHNIQUES

ENDOSCOPIC ULTRASONOGRAPHY

CHROMOENDOSCOPY AND NARROW BAND IMAGING

CONFOCAL LASER MICROSCOPY (ENDOMICROSCOPY)

NEW TECHNIQUES

COMPLICATIONS

References

Chapter 62 - Colonoscopy, Polypectomy, and Related Techniques

PERSONNEL, SEDATION, AND ANTIBIOTIC PROPHYLAXIS

EQUIPMENT

INDICATIONS

CONTRAINDICATIONS

PREPARATION

ANATOMY

TECHNIQUE

BIOPSY TECHNIQUE

THERAPEUTIC COLONOSCOPY

INJECTION

THERMOCOAGULATION: HEATER PROBE, MULTIPOLAR PROBES, AND HOT BIOPSY FORCEPS

STRICTURE DILATION

PERCUTANEOUS CECOSTOMY

POLYPECTOMY

SPECIAL ENDOSCOPIC TECHNIQUES

COMPLICATIONS

REFERENCES

Chapter 63 - Endoscopic Retrograde Cholangiopancreatography

PANCREATICOBILIARY IMAGING METHODS

INDICATIONS FOR ERCP

CONTRAINDICATIONS TO ERCP

PREPARATION FOR ERCP

TECHNIQUE OF ERCP

BILIARY DISORDERS

CHOLEDOCHOLITHIASIS

CHOLEDOCHAL CYST

BILIARY STRICTURES

BILIARY LEAKS

UNUSUAL BILIARY INFECTIONS

BILIARY DYSKINESIA

PANCREATIC DISORDERS

COMPLICATIONS OF ERCP

SUMMARY

References

CAPSULE ENDOSCOPY AND SMALLBOWEL ENTEROSCOPY

EQUIPMENT

PERFORMANCE OF CE STUDY

INDICATIONS

LIMITATIONS

CONTRAINDICATIONS AND COMPLICATIONS

ENTEROSCOPY

COMPLICATIONS

INTRAOPERATIVE ENTEROSCOPY

CONCLUSION

REFERENCES

Chapter 65 - Gastrointestinal Motility Procedures

GASTOINTESTINAL MOTILITY STUDIES

ESOPHAGEAL MANOMETRY

ANTRODUODENAL MANOMETRY

COLONIC MANOMETRY

ANORECTAL MANOMETRY

SUMMARY

References

Chapter 66 - Gastrointestinal Pathology

ESOPHAGEAL BIOPSY

STOMACH BIOPSY

SMALL INTESTINAL BIOPSY

INTERPRETATION OF COLONIC MUCOSAL BIOPSY SPECIMENS IN THE EVALUATION OF INFLAMMATORY BOWEL DISEASE

EVALUATION OF RESECTION SPECIMENS IN INFLAMMATORY BOWEL DISEASE

DISORDERS OF INTESTINAL MOTILITY

GASTROINTESTINAL POLYPS AND POLYPOSIS SYNDROMES

ACKNOWLEDGMENTS

References

Section 8 The Liver and Bile Ducts

Chapter 67 - Developmental Anatomy and Physiology of the Liver and Bile Ducts

EARLY DEVELOPMENT OF THE LIVER IN HUMANS AND OTHER VERTEBRATES

DEVELOPMENT OF THE BILIARY TREE

DEVELOPMENT OF THE HEPATIC VASCULATURE

THE FUNCTIONAL UNIT OF THE LIVER: THE HEPATIC LOBULE AND SINUSOIDAL SYSTEM

FUNCTIONAL DEVELOPMENT OF THE LIVER

LIVER AS A METABOLIC ORGAN

LIVER AS A FILTER

LIVER AS A HEMATOPOIETIC ORGAN

LIVER AS AN IMMUNE ORGAN

STEM CELLS AND LIVER REGENERATION

CONCLUSION

ACKNOWLEDGMENTS

References

Chapter 68 - Neonatal Hepatitis

APPROACH TO THE INFANT WITH CHOLESTASIS

CHOLESTASIS ASSOCIATED WITH INFECTION

SYSTEMIC CONDITIONS ASSOCIATED WITH NEONATAL HEPATITIS

IDIOPATHIC NEONATAL HEPATITIS

MANAGEMENT OF NEONATAL CHOLESTASIS

SUMMARY

ACKNOWLEGMENTS

References

Chapter 69 - Biliary Atresia and Neonatal Disorders of the Bile Ducts

SURGICALLY CORRECTABLE DISORDERS

References

Chapter 70 - Pediatric Cholestatic Liver Disease with Genetic Etiology

DEFECTS IN BILE ACID PRODUCTION

DEFECTS IN MEMBRANE TRANSPORTERS

DISORDERS OF EMBRYOGENESIS: ALAGILLE SYNDROME

DISORDER OF MITOCHONDRIAL FUNCTION

GENETIC CHOLESTASIS

References

Chapter 71 - Mitochondrial Hepatopathies:

FAO DISORDERS

PHYSIOLOGY OF NORMAL FAO

EPIDEMIOLOGY AND GENETICS OF FAO DISORDERS

CLINICAL PRESENTATIONS OF FAO DISORDERS

DIAGNOSIS OF FAO DISORDERS

TREATMENT OF DISORDERS OF FAO

RESPIRATORY CHAIN DISORDERS

MITOCHONDRIAL RC GENETICS AND BIOLOGY

EPIDEMIOLOGY OF RC DISORDERS

CLINICAL PRESENTATION

GENETICS OF MITOCHONDRIAL HEPATOPATHIES

DIAGNOSIS OF MITOCHONDRIAL HEPATOPATHIES

TREATMENT OF MITOCHONDRIAL HEPATOPATHIES

References

Chapter 72 - Abnormalities of Hepatic Protein Metabolism

α1-ANTITRYPSIN DEFICIENCY

TYROSINEMIA

UREA CYCLE DEFECTS

References

Chapter 73 - Abnormalities of Carbohydrate Metabolism and the Liver

NONALCOHOLIC FATTY LIVER DISEASE

GALACTOSEMIA

HEREDITARY FRUCTOSE INTOLERANCE

FRUCTOSE-1,6-BISPHOSPHATASE DEFICIENCY

GLYCOGEN STORAGE DISEASE

References

Chapter 74 - Nonalcoholic Fatty Liver Disease

DEFINITION AND CAUSES

PREVALENCE AND DEMOGRAPHIC PREDICTORS

PATHOPHYSIOLOGY

NATURAL HISTORY

SIGNS AND SYMPTOMS

DIAGNOSIS

TREATMENT

PREVENTION AND SCREENING

CONCLUSION

References

Chapter 75 - Acute and Chronic Hepatitis

EVALUATION OF THE CHILD WITH HEPATITIS

HEPATOTROPIC VIRUSES

AUTOIMMUNE HEPATITIS

NONALCOHOLIC FATTY LIVER DISEASE

TREATMENT OF HEPATITIS

SUMMARY

References

Chapter 76 - Portal Hypertension

PATHOGENESIS OF PORTAL HYPERTENSION

CLINICAL FEATURES

DIAGNOSIS

THERAPY

References

Chapter 77 - Liver Failure

CHRONIC LIVER FAILURE

ACUTE LIVER FAILURE

SUMMARY

References

Chapter 78 - Liver Transplantation in Children

INDICATIONS FOR LIVER TRANSPLANTATION

GENERAL CONTRAINDICATIONS FOR LIVER TRANSPLANTATION IN CHILDREN

EVALUATION OF PEDIATRIC LIVER TRANSPLANT CANDIDATES

PREPARATION FOR LIVER TRANSPLANTATION

ORGAN ALLOCATION

LIVER TRANSPLANTATION SURGERY

POSTTRANSPLANT MANAGEMENT AND COMPLICATIONS

GROWTH AND DEVELOPMENT AND QUALITY OF LIFE

NONADHERENCE WITH IMMUNOSUPPRESSION

SURVIVAL AFTER LIVER TRANSPLANTATION

LIVER TRANSPLANTATION IN SPECIAL GROUPS

WITHDRAWAL OF IMMUNOSUPPRESSION AND TOLERANCE

CONCLUSION

References

Chapter 79 - Diseases of the Gallbladder

EPIDEMIOLOGY OF GALLSTONE DISEASE

PATHOPHYSIOLOGY OF GALLSTONE DISEASE

CHOLESTEROL STONES

PIGMENT STONES

GALLSTONES IN INFANTS

TOTAL PARENTERAL NUTRITION–ASSOCIATED STONES

CYSTIC FIBROSIS–ASSOCIATED GALLSTONES

ILEAL DISEASE AND ILEAL RESECTION-ASSOCIATED STONES

DRUG-ASSOCIATED STONES

DIAGNOSIS OF GALLSTONE DISEASE

TREATMENT OF GALLSTONE DISEASE

CHOLECYSTITIS

CHOLEDOCHOLITHIASIS (COMMON BILE DUCT STONES)

ACALCULOUS CHOLECYSTITIS

ACUTE HYDROPS OF THE GALLBLADDER

UNUSUAL DISEASES OF THE GALLBLADDER

References

Section 9 The Pancreas

Chapter 80 - Pancreatic Development

BUDS FORM AND FUSE

DUCTAL SYSTEM FORMS

DIFFERENTIATION OF PANCREATIC PROGENITORS

PROGRAMMED DEVELOPMENT BY HIERARCHICAL SIGNALS

REGENERATIVE CAPACITY OF THE PANCREAS

SUMMARY ON PANCREATIC DEVELOPMENT

PANCREATIC SECRETION AND EXOCRINE FUNCTION

References

Chapter 81 - Cystic Fibrosis and Congenital Anomalies of the Exocrine Pancreas

CYSTIC FIBROSIS

STRUCTURAL ABNORMALITIES OF THE PANCREAS

FUNCTIONAL ABNORMALITIES OF THE PANCREAS

References

Chapter 82 - Pancreatitis

ACUTE AND CHRONIC PANCREATITIS

ACUTE PANCREATITIS

CHRONIC PANCREATITIS

References

Chapter 83 - Total Pancreatectomy with Autoislet Transplantation, and Pancreatic Allotransplantation

TOTAL PANCREATECTOMY WITH AUTOISLET TRANSPLANTATION (TP-AIT)

WHOLE-ORGAN PANCREAS ALLOTRANSPLANTATION

PANCREATIC ISLET ALLOTRANSPLANTATION

References

Chapter 84 - Secretory Neoplasms of the Pancreas

MULTIPLE ENDOCRINE NEOPLASIA

INSULINOMA

CONGENITAL HYPERINSULINISM

GASTRINOMA: ZOLLINGER-ELLISON SYNDROME

VIPOMA

OTHER TUMORS

SUMMARY

References

Chapter 85 - Infant and Toddler Nutrition

GROWTH

BREAST-FEEDING

FORMULA FEEDING

COMPLEMENTARY FEEDING

SUPPLEMENTS

TODDLERS

DESCRIPTIVE INFORMATION

EXPERIMENTAL INFORMATION

SPECIFIC NUTRIENT DEFICITS

TODDLERS’ NUTRITON AND STOOLING

PSYCHOLOGY OF TODDLERS’ NUTRITION

References

Section 10 Nutrition

Chapter 86 - Nutritional Assessment

EPIDEMIOLOGY OF NUTRITIONAL DISORDERS IN PEDIATRIC PATIENTS

CLINICAL SIGNIFICANCE OF NUTRITIONAL ASSESSMENT

CLINICAL FEATURES OF NORMAL GROWTH AND BODY COMPOSITION IN CHILDREN

INDICATIONS FOR NUTRITIONAL ASSESSMENT

COMPONENTS OF NUTRITIONAL ASSESSMENT

SUMMARY

ACKNOWLEDGMENTS

References

Chapter 87 - Tubes for Enteric Access

EVALUATION

CONSIDERATIONS FOR SHORT-TERM ACCESS

CONSIDERATIONS FOR LONG-TERM ACCESS

GASTROESOPHAGEAL REFLUX AND TUBES

SUMMARY

References

Chapter 88 - Parenteral Nutrition

INDICATIONS

ROUTE OF ADMINISTRATION

PARENTERAL NUTRITION COMPONENTS AND REQUIREMENTS

MONITORING

COMPLICATIONS

TOTAL NUTRIENT ADMIXTURES

FORMULATING A REGIMEN

CYCLIC PARENTERAL NUTRITION

HOME PARENTERAL NUTRITION

MONITORING THE HOME PN PATIENT

SUMMARY

References

Chapter 89 - Enteral Nutrition

MALNUTRITION IN THE HOSPITAL SETTING

INDICATIONS FOR ENTERAL FEEDING (TABLE 89-1)

GROWTH FAILURE ASSOCIATED WITH CHRONIC DISEASE

HYPERMETABOLIC STATES

CHOICE OF ENTERAL FEEDING ROUTE

CHOICE OF FEEDING METHOD (CONTINUOUS, NOCTURNAL, OR BOLUS FEEDING)

ENTERAL NUTRITION IN THE NEONATE

ENTERAL FEEDING IN THE INFANT AND CHILD

PRACTICAL ISSUES OF ENTERAL NUTRITION

SAFETY OF ENTERAL FEEDS

COMPLICATIONS

TRANSITION FROM PARENTERAL TO ENTERAL/ORAL NUTRITION

SUMMARY

References

Chapter 90 - Management of Diarrhea

MANAGEMENT OF ACUTE DIARRHEA

MANAGEMENT OF CHRONIC DIARRHEA

References

Chapter 91 - Effects of Digestive Diseases on Bone Metabolism

BONE BIOLOGY IN CHILDREN

PEAK BONE MASS

MEASUREMENT OF BONE METABOLISM AND BONE MASS IN CHILDREN

DEFINITION OF OSTEOPOROSIS IN CHILDREN

COMMON MECHANISMS BY WHICH DIGESTIVE DISEASES AFFECT BONE MASS

SELECTED GASTROINTESTINAL DISEASES ASSOCIATED WITH DECREASED BMD

LIVER DISEASES

CYSTIC FIBROSIS

TREATMENT

References

Chapter 92 - Nutrition and Feeding for Children with Developmental Disabilities

NUTRITIONAL GOALS AND RISKS

VARIABILITY IN NEEDS

CONTRIBUTING FACTORS

PRESENTATION AND EVALUATION

INTERVENTION

ORAL FEEDING

ORAL FEEDING PROBLEMS

ENTERAL DELIVERY

SUMMARY

References

Index

Color Plates

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