Chapter
Chapter 1: Neuropathology Patterns and Introduction
Central Nervous System Tumor Classification Schemes and Additional “Neuropathology Patterns”
Chapter 2: Normal Brain Histopathology
Chapter 3: Intraoperative Consultation and Optimal Processing
Types of Neurosurgical Specimens
Intraoperative Cytologic Preparations as a Complement to Frozen Tissue Sections
Fixation and Staining Options for Intraoperative Cytologic Preparations
Frozen Sectioning of Central Nervous System Tissue
Iatrogenically Introduced Hemostatic
and Embolic Agents
The Bottom Line: What Does the SurgeonNeed to Know?
Chapter 4: Neuroradiology: The Surrogate of Gross Neuropathology
Basic Noninvasive Diagnostic Imaging Techniques
Advanced Noninvasive Diagnostic Imaging Techniques
Basic Invasive Diagnostic Imaging Techniques
Advanced Invasive Therapeutic Techniques
Imaging Patterns in Neuroradiology
Advanced Strategies of Lesion Analysis
Chapter 5: Astrocytic and Oligodendroglial Tumors
Introduction and Brief Historical Overview
Subependymal Giant-Cell Astrocytoma
Pleomorphic Xanthoastrocytoma
Chapter 6: Ependymomas and Choroid Plexus Tumors
Brief Historical Overview
Chapter 7: Neuronal and Glioneuronal Neoplasms
Gangliogliomas and Gangliocytomas (“Ganglion Cell Tumors”)
Desmoplastic Infantile Astrocytoma
and Ganglioglioma
Dysplastic Gangliocytoma of the Cerebellum (Lhermitte-Duclos Disease)
Central Neurocytoma and Other Neurocytic Neoplasms
Cerebellar Liponeurocytoma
Dysembryoplastic Neuroepithelial Tumor
Papillary Glioneuronal Tumor
Rosette-Forming Glioneuronal Tumor
of the Fourth Ventricle
Chapter 8: Pineal Parenchymal Tumors
Introduction, Definitions, and Synonyms
Brief Historical Overview
Incidence and Demographics
Localization and Clinical Manifestations
Radiologic Features and Gross Pathology
Histologic Variants and Grading
Principles of Diagnosis and Grading on
Small or Artifact-Ridden Samples
Ancillary Diagnostic Studies
Chapter 9: Embryonal (Primitive) Neoplasms of the Central Nervous System
Brief Historical Overview
Medulloblastoma (Cerebellar Primitive Neuroectodermal Tumor)
Central Nervous System Supratentorial Primitive Neuroectodermal Tumors and Related Embryonal Neoplasms
Atypical Teratoid Rhabdoid Tumor
Introduction and Proposed Etiologies
Definition and Analogies with Meningothelial Cells
Brief Historical Overview of Nomenclature and Histogenetic Notions
Incidence and Demographics
Localization and Clinical Manifestations
Radiologic Features and Gross Pathology
Histologic Variants and Grading
Meningiomas That Are Mostly Benign (WHO Grade I)
WHO Grade III (Malignant) Meningiomas
Other Meningioma Patterns Not Included in the WHO
Metastasis of and to Meningiomas
Ancillary Diagnostic Studies
Chapter 11: Mesenchymal Tumors of the Central Nervous System
Brief Historical Overview
Incidence and Demographics
Fibroblastic–Myofibroblastic Tumors
Miscellaneous Tumors and Tumor-like Lesions
Chapter 12: Peripheral Nerve Sheath Tumors
Miscellaneous Benign Neurogenic Tumors
Primary Malignant Tumors of Nerve
Malignant Granular Cell Tumor
Primitive Neuroectodermal Tumor of the Nerve
Chapter 13: Epithelial, Neuroendocrine, and Metastatic Lesions
Metastatic Epithelial and Epithelioid Neoplasms
Papillary Tumor of the Pineal Region
Cysts of the Central Nervous System
Chapter 14: Lymphomas and Histiocytic Tumors
Chapter 15: Germ Cell Tumors
Brief Historical Overview
Incidence and Demographics
Clinical Manifestations and Localization
Radiologic Features and Gross Pathology
Ancillary Diagnostic Studies
Chapter 16: Melanocytic Neoplasms of the Central Nervous System
Brief Historical Overview
Melanocytoma and Melanoma
Neurocutaneous Melanosis/Melanomatosis
Chapter 17: Other Glial Neoplasms
Chapter 18: Pathology of the Pituitaryand Sellar Region
The Sellar Region and Normal Pituitary
Anterior Pituitary Tumors
Invasion and Malignancy in Anterior
Pituitary Tumors
Other Primary Pituitary Tumors
Miscellaneous Sellar Region Tumors
Chapter 19: Therapy-Associated Neuropathology
Radiation Necrosis and Other Forms
of Radiation Injury
Therapy-Induced Leukoencephalopathies and Vasculopathies
Therapy-Induced Secondary Neoplasms
Chapter 20: Familial Tumor Syndromes
Tuberous Sclerosis Complex
Von Hippel-Lindau Disease
Nevoid Basal Cell Carcinoma Syndrome (Gorlin Syndrome)
Rhabdoid Predisposition Syndrome
Chapter 21: Infections and Inflammatory Disorders
Focal Discrete Central Nervous System Infection
Inflammatory Conditions of the Nervous System Mimicking Infections
Central Nervous System Manifestations of Rheumatoid Arthritis
Central Nervous System Manifestations of Wegener Granulomatosis
Chapter 22: White Matter and Myelin Disorders
Acute Disseminated Encephalomyelitis
Acute Hemorrhagic Leukoencephalitis
Progressive Multifocal Leukoencephalopathy
Subacute Sclerosing Panencephalitis
HIV Leukoencepahlopathy and Vacuolar Myelopathy
Binswanger Encephalopathy
Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy
Osmotic Demyelination Syndrome (Central Pontine and Extrapontine Myelinolysis)
Chapter 23: Pathology of Epilepsy
Malformations of Cortical Development (Cortical Dysplasia)
Infarct Including Porencephalic Cyst
Chapter 24: Vascular and Ischemic Disorders
Ischemic Cerebral Infarct
Hypertensive Cerebrovascular Disease
Cerebral Amyloid Angiopathy
Vasculitis Involving the Nervous System
Primary Angiitis of the Central Nervous System
Fusiform and Infective (“Mycotic”) Aneurysms
Cerebral Autosomal Dominant Arteriopathy
with Subcortical Infarcts and Leukoencephalopathy
Chapter 25: Biopsy Pathology of Neurodegenerative Disorders in Adults
Dementia with Lewy Bodies and Idiopathic Parkinson Disease
Frontotemporal Lobar Degeneration
and Pick Disease
Human Prion Diseases (Transmissible Spongiform Encephalopathies) Including Creutzfeldt-Jakob Disease
Practical Surgical Neuropathology: A Diagnostic Approach
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