Recurrent Pregnancy Loss - ECAB

Author: Rao> Kamini  

Publisher: Elsevier Health Sciences APAC‎

Publication year: 2009

E-ISBN: 9788131232255

P-ISBN(Paperback): 9788131215906

Subject: R714.21 abortion, premature birth and postmature pregnancy

Keyword: 妇产科学

Language: ENG

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Description

Recurrent miscarriage is a distressing problem that affects 1% of all women in the reproductive age group. This incidence is greater than that expected by chance alone, since 10-15% of all clinically recognised pregnancies end in a miscarriage. The calculated risk of three consecutive pregnancy losses is estimated to be 0.34%. Hence, only a proportion of women presenting with recurrent miscarriage will have a persistent underlying cause for their pregnancy losses. Maternal age and previous number of miscarriages are two independent risk factors for a further miscarriage. The advanced maternal age adversely affects ovarian function, giving rise to a decline in the number of good quality oocytes, resulting in chromosomally abnormal conceptions that rarely develop further. The eminent authors for "e;Recurrent Pregnancy Loss"e; have enumerated the various options available described in detail their experiences regarding the various aspects of the condition.

Chapter

ECAB Clinical Update InformationRecurrent Pregnancy Loss

Introduction

Genetics of Recurrent Pregnancy Loss

Abstract

Keywords

Parental Chromosomal Abnormalities

Balanced Translocations

Inversions

Chromosome Mosaicism

Single Gene Abnormalities

Other Genetic Mechanisms

Aberrant Gene Expression

Management

Case Studies Genetics of Recurrent Pregnancy Loss

Case 1

Case 2

Case 3

Management of.Repeated Pregnancy Losses

Abstract

Keywords

Age of The Woman

Germ Cell Abnormalities

Chromosomal Abnormalities

Maternal Nutrition

Maternal Stress

Maternal Systemic Diseases

Syphilis

Systemic Lupus Erythematosus

Thyroid Dysfunction

Hormonal Deficiencies

Diabetes

Progesterone Deficiency

Corpus Luteal Phase Defect

Polycystic Ovarian Disease

Androgen Levels

Genital Tract Abnormalities

Infections

Immunological Causes

Auto-Immune Disorders

Management

Cellular Immunity

Allo-Immune Dysfunction

Management

Conclusions

Case Studies Management of Repeated Pregnancy Losses

Case 1

Discussion

Case 2

Discussion

Case 3

Case 4

Antiphospholipid Syndrome

Abstract

Keywords

Introduction

Classification of Antiphospholipid Syndrome

Antiphospholipid Antibodies

Prevalence And Epidemiology

Apl And its Association With Recurrent Pregnancy Loss

Etioliogy of Antiphospholipid Antibodies

Pathogenesis

Placental Insufficiency

Complement Activation

Cellular Dysfunctions

Clinical Manifestation

Diagnosis

Diagnostic Tests

Management Of Recurrent Pregnancy Loss In Antiphospholipid Syndrome

Preconceptional Counseling

Pharmacologic Therapy

Aspirin

Heparin

Warfarin

Intravenous Immunoglobulin

Recommendations for Treatment

Conclusion

Infections and Recurrent Pregnancy Loss

Abstract

Keywords

Introduction

Pathogenesis

Immune Modulation by Pregnancy and Reactivation of Dormant Infections

Various Microorganisms Implicated in Recurrent Pregnancy Loss

Mycobacterium Tuberculosis

Bacterial Vaginosis

Mycoplasma hominis and Ureaplasma urealyticum

Listeria monocytogenes

Chlamydia

Treponema pallidum

Lyme Disease

Viruses

Cytomegalovirus

Herpes Simplex Virus

Plasmodium falciparum

Toxoplasma gondii

Conclusion

Case Studies Infections and Recurrent Pregnancy Loss

Case 1

Case 2

Summary

Genetics of Recurrent Pregnancy Loss

Antiphospholipid Syndrome

Infections and Recurrent Pregnancy Loss

Management

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